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WorksheetsCase 7 - The immune system and its responses
Total questions: 19
Worksheet time: 10mins
Name
Class
Date
1.
Q1 – A 7-year-old has contracted a rhinovirus infection and in response creates antibodies. What is the name of the site on the antigen that their antibodies bind to?
a)
A. Alloantibody
b)
B. Autoantibody
c)
C. Epitope
d)
D. Paratope
e)
E. Antitope
2.
Q2 – An immunogen is…
a)
A. Any foreign molecule that generates antibodies
b)
B. Any molecule that can induce an immune response
c)
C. Any molecule that cause an allergic reaction
d)
D. Any molecule that cause an hypersensitivity reaction
3.
Q3 – Which of the following are not 1 of the 4 “R’s” describing the functions of the immune system:
a)
A. Recognition
b)
B. Retention
c)
C. Regulation
d)
D. Renewal
e)
E. Reaction
4.
Q4 – A child receives various antibodies from their mother via the placenta and breastfeeding that provide immunity – What is this an example of?
a)
A. Artificial active immunity
b)
B. Natural active immunity
c)
C. Artificial passive immunity
d)
D. Natural passive immunity
5.
Q5 – Select the most accurate definition of a chemokine
a)
A. A small protein that alters the behaviour of another cell, typically immune cells e.g. IL-6
b)
B. A small protein that stimulates migration and activation of cells e.g. CXCL-8
c)
C. A small protein that causes vasodilation thus slowing down blood flow and allow immune cells to undergo extravasation
d)
D. A small protein that stimulates migration and activation of cells e.g. IL-1Beta
6.
Q6 – Which of the following statements best describes the response of macrophages to an overwhelming number of pathogens!
a)
A. Macrophage uses phagocytic pattern recognition receptors (PPRs)
b)
B. Oxidative burst is activated!
c)
C. Signalling pattern recognition receptors (PPRs) are activated e.g. Toll-like receptors
d)
D. Phagocytic pattern recognition receptors (PPRs) are activated e.g. Toll-like receptors
7.
Q7 – Which of the following statements does NOT describe a function of interferons:
a)
A. Prevent viral replication by protecting cells from viral infection/entry
b)
B. Increase host defences by up-regulating antigen presentation via increasing the expression of major histocompatibility complex 2 (MHC-2) antigens
c)
C. Activate immune cells e.g. dendritic cells, natural killer cells or macrophages
d)
D. Increase host defences by up-regulating antigen presentation via increasing the expression of major histocompatibility complex 1 (MHC-1) antigens
8.
Q8 – Which of the following acute phase proteins are NOT involved in the opsonisation of pathogens?
a)
A. Complement factors
b)
B. C-reactive protein
c)
C. Fibrinogen
d)
D. Mannose-binding lectin
9.
Q9 – Which complement pathway can be activated by antigen-antibody complexes and uses a component that is not produced in the liver?
a)
A. Alternative Pathway
b)
B. Classical Pathway
c)
C. Mannose Pathway
d)
D. Lectin Pathway
10.
Q10 – Which of the following cells do not originate from a common myeloid progenitor cell?
a)
A. Myeloblast
b)
B. Monocyte
c)
C. Dendritic cell
d)
D. Natural killer cell
e)
Megakarocyte
11.
Q11 – Who’s that immune cell!
a)
A. Eosinophil
b)
B. Mast cell
c)
C. Basophil
d)
D. Macrophage
e)
E. Neutrophil
12.
Q12 – Who’s that immune cell!
a)
A. Eosinophil
b)
B. Mast cell
c)
C. Basophil
d)
D. Macrophage
e)
E. Neutrophil
13.
Q13 – Who’s that immune cell!
a)
A. Dendritic cell
b)
B. Mast cell
c)
C. Basophil
d)
D. Macrophage
e)
E. Monocyte
14.
Q14 – Which of the following statements is a false statement about the differences between B cells and T cells
a)
A. B cells are capable of producing antibodies by differentiating into plasma cells, while T cells cannot
b)
B. T cells can only recognise “processed antigens” that are presented on MHC-2 complexes while B cells can recognise native antigens
c)
C. B cells are created in the bone marrow while T cells are created in the thymus
d)
D. T cells are capable of producing much more cytokines than B cells
e)
E. Both T cells and B cells can become memory cells
15.
Q15 – Which of the following describes a factual difference between immature and mature dendritic cells:
a)
A. Immature dendritic cells circulate in the tissues and lymph, while mature dendritic cells circulate in the tissues and blood
b)
B. Immature dendritic cells circulate in the lymph and blood, while mature dendritic cells circulate in the tissues
c)
C. Immature dendritic cells circulate in the tissues and blood, while mature dendritic cells circulate in the tissues and lymph
d)
D. Immature dendritic cells only circulate in the blood, while mature dendritic cells only circulate in the lymph
16.
Q16 – Which of the following does NOT describe how natural killer cells act:
a)
A. MHC-1 mediated cytolytic granule mediated cell apoptosis
b)
B. B-cell antibodies that have bound to the surface of virally infected or tumorigenic cells can be recognised by the CD16 receptor
c)
C. Abnormal antigens expressed on a cell’s MHC-1 complex is detected
d)
D. Natural killer cells degranulate cytotoxic granules containing perforin that makes holes in cells membranes and granzymes that destroy proteins and trigger apoptosis
17.
Q17 – Which of the following inflammatory mediators are not capable of causing blood vessel vasodilation to aid the extravasation of immune cells:
a)
A. Plasma proteins created by the liver
b)
B. Histamine created by mast cells and basophils
c)
C. Prostaglandins created by mast cells, neutrophils and basophils
d)
D. Cytokines created by mast cells and macrophages
e)
E. Leukotrienes created by mast cells, neutrophils and basophils
18.
Q18 – Which surface protein is used by leukocytes to undergo transmigration/diapedis when leaving a blood vessel and enter its target tissue?
a)
A. Integrin
b)
B. Selectin
c)
C. PECAM-1
d)
D. Integrase
19.
Q19 – What type of inflammation is this:
a)
A. Serous inflammation
b)
B. Granulomatous inflammation
c)
C. Fibrinous inflammation
d)
D. Purulent/Suppurative inflammation
e)
E. Abscess inflammation
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