Substances that ameliorate the difficulties on manufacture of a compressed tablet are known as:

Which of the following are TRUE about Lubricants?

Which of the following are TRUE about Glidants?

Which of the following function to prevent tablet granules from sticking to faces of punches and die wall ?

The Phenomenon of picking Tablet defect means too much moisture; inadequate

anti-adherent; insufficient compressibility.

Surface materials of the tablet stick to the punch and get removed from the tablet surface.

Which of following Lubricants can I use if I want it to be an excellent lubricant but poor anti-adherent or glidant?

Which of the following Lubricants may retard drug dissolution If used in greater than 1% concentration?

Which of following Lubricants can I use if I want an excellent glidant and anti-adherent but is a poor lubricant? 

Which of following Lubricants can I use if I want a good lubricant property; however, it is a poor anti-adherent and lacks glidant property?

Carbowax 4000, carbowax 8000, and sodium lauryl sulfate (effective in 1 to 5% concentration).

In general lubricants, whether water soluble or insoluble, should be of thick particle size.

In general lubricants, whether water soluble or insoluble, should be of very fine particle size.

Lubricants function by forming a thin film around the granules.

Which of the following is TRUE about the Effectiveness of Lubricants?

Which of the following will facilitate tablet breakup following its administration?

Rapid disintegration is likely to result in rapid drug dissolution; though it is not an absolute guarantee.

In the Tablet disintegration process, Aqueous fluid will enter tablet through the capillary structure; swelling of disintegrating agent will build the pressure inside the tablet.

Which of the following is more critical and vital for rapid and complete drug absorption to occur?

Which of the following is TRUE about the Disintegrating agent?

The effectiveness of many disintegrants is affected by their position (inter granular or extra-granular) within the tablet.

Which of the following suggests the presence of disintegrant inside or within the granules?

Which of the following suggests the presence of disintegrating agent between the granules?

What is the mode of action of commonly used Disintegrant?

PrimojelR or Explotab are examples of which of the following?

We can say Low substituted carboxymethyl starch is used in about 1 to 8% (optimum is 4%) concentration as a Disintegrant.

Which of the following are considered Pre-gelatinized starch (Disintegrants)? Select all that apply

Which of the following statements are TRUE about Colorants? Select all that apply

Any of the water soluble dyes, mixture of the dyes and their corresponding lakes may be used as colorants for tablets.

Aluminum hydroxide is an insoluble form of the dye.

Dyes are water soluble while lakes, which are formed by the adsorption of water-soluble dye on a hydrous oxide.

Dyes and lakes are photosensitive, and their photosensitivity is affected by the drug, excipient and the method of manufacture.

Which of the following statements are TRUE about Dyes? Select all that apply

Pastel shades generally show least amount of mottling (an uneven distribution of color yielding darker spots of the color on a tablet).

Yellow and green color (midrange of visible spectrum) will show less mottling compared to blue and red.

The problems of mottling becomes more pronounced when the concentration increases.

The problems of mottling becomes more pronounced when the concentration decreases.

Which of the following parameters are related to the Mottling Phenomenon? Select all that apply

The Migration of the coloring agent from inside of a granule to the surface of a granule is during the drying process.

Drying granules slowly at low temperature and with continuous stirring can reduce migration of the color to the surface and reduce mottling.

Drying granules slowly at High temperature and with continuous stirring can reduce migration of the color to the surface and reduce mottling.

Which of the following are the commonly employed colorants? Select all that apply

Coloring agents are used in very small concentrations (0.05 to 0.1%)

Coloring agents are used in very large concentrations (5 to 10%).

Coloring agents are generally mixed with which of the following binding agent solutions? Select all that apply

It is much easier to incorporate coloring agent as a solution than as a powder.

It is much easier to incorporate coloring agent as a powder than as a solution.

Lakes, on the other hand, are blended with dry excipients because of their insoluble nature.

When we talk about Tablet Capping (defect) problem, we are talking about which of the following? Select all that apply

Which of the following methods are used to prepare tablets? Select all that apply

Which of the following are considered the powder properties? Select all that apply

The choice of method of Tablet Preparation depends upon the following factors: Select all that apply

In Wet Granulation, Powdered drug is mixed with which of the following? Select all that apply

In Wet Granulation, Wet powder mixture is passed through a sieve of what sizes? Select all that apply

Which of the following statements are TRUE about Wet Granulation? Select all that apply

Each granule contains drug, binding agent, diluent, Coloring agent, and other excipient.

Which of the following are TRUE about Advantages of Wet Granulation ? Select all that apply

Which of the following are TRUE about Limitations of Wet Granulation ? Select all that apply

In Direct Compression, the powder blend of active ingredient and excipients is compressed into a tablet.

Which of the following are TRUE about the steps in Direct Compression? Select all that apply

If I'm looking for an economical and suitable method for heat and moisture sensitive drugs, Direct Compression is an option.

Direct Compression is not ideal for low dose drugs and antacid drugs due to high dose, high bulk volume (i.e., low bulk density), poor compressibility, and poor flow present difficulty in direct compression.

Which of the following tests are performed by the manufactures to evaluate tablets? Select all that apply

How many tablets are weighted individually in the Weight Variation Test?

Which of the following are TRUE statements about the Weight Variation Test? Select all that apply

Understand this!

How many tablets are assayed individually for drug content in the Drug Content Uniformity test?

Which of the following are TRUE statements about the Drug Content Uniformity test? Select all that apply

Which test is designed to establish drug homogeneity (homogenous distribution of drug) in tablets of each batch of a product?

Which of the following determines the time required for a tablet to disintegrate, when immersed in some test fluid; generally, simulated gastrointestinal fluid?

If a tablet disintegrates quickly, it is likely (not an assurance) that drug will dissolve quickly and absorb immediately.

Understand this

Disintegration test is performed as a quality control test for tablets intended to be administered orally including chewable tablets.

Disintegration test is performed as a quality control test for tablets intended to be administered orally (exception is chewable tablet).

Disintegration test may be far more important for ODT type tablets.

The quicker and more complete the drug dissolution, the faster and more complete is likely to be the drug absorption.

Which of the following is a process by which a solid drug dissolves in the surrounding fluid?

The quicker and more complete the drug dissolution, the faster and more complete is likely to be the drug absorption.

Which of the following are considered the USP dissolution apparatus methods? Select all that apply

The Tablet Hardness Test will help tablet must be sufficiently strong and resistant to abrasion to withstand handling during the manufacturing, packaging, and shipping, in addition to “physical abuse” in a pharmacy by staff and, at home, by the patient.

Which test is performed by measuring the force required to fracture a tablet (measurement of the crushing strength of a tablet)?

Which test measures the weight loss in tablets upon subjecting certain number of tablets to agitation under standard conditions for a specified time?

Which of the following statements are TRUE about the Friability Test (Resistance to abrasion)? Select all that apply

In the Friability Test we must place 20 tablets of known initial weight or W0) and rotate at a fixed RPM for 10 minutes and re-weigh tablets (W).

Resistance to the abrasion (B) is usually expressed as % loss in weight of (10) tablets.

Which value is is frequently quoted as the upper limit for the acceptability of a product for the resistance to the abrasion (B)?

Which of these variables represent the index of abrasion to resistance?

Which of these variables represent the initial weight of ten tablets?

Which of these variables represent the final weight of ten tablets?

Which of the following statements are TRUE about Keppra (Levetiracetam)? Select all that apply

Which of the following are the Physical Chemical

Properties of levetiracetam? Select all that apply

Levetiracetam is available in 250, 500, 750, and 1000 mg tablets and solution.

Which of the following are the inactive ingredients of Levetiracetam? Select all that apply

Which of the following are the inactive ingredients of Levetiracetam? Select all that apply

Which of the following are the inactive ingredients of Levetiracetam? Select all that apply

Which of the following are the inactive ingredients of Levetiracetam? Select all that apply

Which of the following has very good absorbing agent, poor lubricant and excellent anti-adherent property?

Which of the following Levetiracetam tablets have FD & C Blue # 2 and yellow iron oxide?

Which of the following Levetiracetam tablets have FD & C Blue # 2, FD & C yellow # 6, and red iron oxide?

The effectiveness of lubricants is related to particle size and specific surface.

Which of the following Levetiracetam tablets have FD & C Blue # 2 only?

Are added to the formulation to increase the bulk of a tablet to a practical and convenient size.

Diluents are very important for which of the following drugs? Select all that apply

Which of the following are the commonly used Diluents? Select all that apply

Which of the following Diluents are commonly used in chewable tablets? Select all that apply

Diluents are essential to produce a tablet of a reasonable size.

This excipient is incorporated in the formulation to impart cohesive property to the powder mixture (granules). The cohesiveness ensures that tablet will remain intact after compression and until patient uses it.

Effective as a binding agent only in the paste form; one of best general binding agents.

Alcoholic solution is desirable when therapeutic agent is susceptible to hydrolysis. Select all that apply

Which of the following binders are more effective when used as mucilage, compare to dry powder and require presence of a preservative? Select all that apply

Ethyl cellulose is a Cellulose Derivative Binder. Which of the following is true?

Which of the following excipients must have hard gelatin capsules? Select all that apply

Which of the following excipients must have Tablets? Select all that apply

Which of the following excipients must have Powders?

Which of the following DOES NOT require Preservatives?

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Which of the following are the commonly used anti-oxidant? Select all that apply

Which of the following are the commonly used preservatives in oral

products (Liquid & solid dosage forms)? Select all that apply

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Which of the following HAS NO UNITS? Select all that apply

Surface area/gram (mm2/g).

Which of the following will have an impact on tablet weight, content uniformity, disintegration, & dissolution? Select all that apply

Lubricants, anti-adherent, and glidants are generally mixed with dry granules prior to the process of compression of granules into the tablet.

Lubricants, anti-adherents, and glidants which are inactive ingredients are mixed with dry granules of powder prepared by mixing active ingredient (s) with other excipients such as diluent, binding agent and coloring agent.

Which of the following are examples of Lubricants? Select all that apply

Which of the following are examples of Glidants? Select all that apply

They are intended to reduce the adhesion between surface of punches and powder granules .

They are intended to promote smooth and uniform flow of granules into tablet die so that each tablet will have same amount of powder mixture.

Indigotine (Indigo shade)

Erythrosine (Pink shade)

Allura red (Red shade)

Tartrazine (Yellow shade)

Sunset yellow (Orange shade)

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