WorksheetsCeutics 2- Exam 1: Yang
Total questions: 35
Worksheet time: 20mins
Select the absorption mechanism that does not require energy and does not have transport selectivity.
Simple Diffusion
Facilitated Diffusion
Active Transport
Transcytosis
Select the absorption mechanism that has a high transport selectivity.
Simple Diffusion
Facilitated Diffusion
Active Transport
Transcytosis
Select the absorption mechanism that has a moderate transport selectivity.
Simple Diffusion
Facilitated Diffusion
Active Transport
Transcytosis
Na+ being transported through an ion channel is a type of ______.
Simple Diffusion
Facilitated Diffusion
Active Transport
Transcytosis
Na+/K+ pump is an example of ______.
Simple Diffusion
Facilitated Diffusion
Active Transport
Transcytosis
Which type of absorption involves membrane targeting proteins and receptors?
Simple Diffusion
Facilitated Diffusion
Active Transport
Transcytosis
What is the unit for P, the permeability coefficient?
length/time
s/cm
ml/min
volume/time
What is the major determinant of cell membrane permeability?
lipophilicity or partition coefficient of the solute
diffusion coefficient of the solute
membrane thickness
Which medication has low solubility and high permeability?
metoprolol
naproxen
ranitidine
HCTZ
Which medication has low solubility and low permeability?
metoprolol
naproxen
ranitidine
HCTZ
Which medication has high solubility and low permeability?
metoprolol
naproxen
ranitidine
HCTZ
Which medication has high solubility and high permeability?
metoprolol
naproxen
ranitidine
HCTZ
When can we use the mathematical expression of sink condition?
When Cd is near zero
When Cr is near zero
When Cr is much much lower than Cd
When Cd is much much lower than Cr
A graph of the amount diffused as a function of time will be a straight line with slope equal to __________
PSCd
PSCr
DSCd
PSCdt
The initial rapid release of a drug from a pre-saturated membrane
Burst effect
Lag-time effect
The time required to saturate the membrane
Burst effect
Lag-time effect
T/F: The lag time is dependent on the diffusion coefficient and the membrane thickness but the burst effect is dependent only on the thickness of the membrane.
True
False
Moderately weak acids are_________ and are better absorbed in the stomach.
unionized in gastric pH
Ionized in in intestinal pH
ionized in gastric pH
unionized in intestinal pH
Which of the following are limitations of the pH-partition therory?
small epithelial surface areas of small intestine
Long residence time in small intestine
Drug ions interact with opposite charged ions
Some drugs are absorbed via active pathways
Drug absorption is affected by its liquid solubility
Which type of gelatin is mainly manufactured from pork skin?
Type A
Type B
Which type of gelatin is mainly manufactured from animal bones?
Type A
Type B
Type A gelatin exhibits an iso-electric point at
pH 9
pH 4.7
Type B gelatin exhibits an iso-electric point at
pH 9
pH 4.7
Gelatin Properties
soluble in cold water
digested by proteolytic enzymes in stomach
soluble in hot water
soluble in warm gastric fluid
What are gelatin alternatives?
gluten
cellulose ethers
starch
PVA
HPMC
____________ gelatin capsules are made of gelatin, water and sugar.
Hard
Soft
What is the moisture tolerance range in hard gelatin shells?
10-20%
13-16%
8-13%
15-18%
All of the following except_________ should be considered when selecting capsule size.
The amount of fill material to be encapsulated
The density and compressibility of the fill
By the result of trial
The color of the material to be encapsulated
Which is not suitable for highly soluble salts?
Hard gelatin capsules
Soft gelatin capsules
Both hard and soft gelatin capsules
T/F Soft gelatin capsules shell can contain active substance.
True
False
Which type of gelatin shell is thicker and consists of a single part that is usually formed, filled, and sealed in one operation?
soft
hard
T/F Soft gelatin capsules should be frozen to avoid the loss of strength or potency.
True
False
__________ gelatin capsules are made of gelatin, glycerin and water.
Soft
Hard
Which has the more rapid release?
Hard gelatin capsules
Soft gelatin capsules
Which is most commonly used in manufacturing soft gel capsules?
plate
rotary die
reciprocating die
