wayground logo

Free Printable Worksheets

Font size

S
M
L
XL
Worksheets

EXAM 1 CEUTICS II DR. YANG Capsules

Total questions: 63

Worksheet time: 1hrs 4mins

Name
Class
Date
1.

Capsules is a liquid dosage form if filled by oil.

a)

True

b)

False

2.

Type B gelatin is mostly from pork skin.

a)

True

b)

False

3.

Hard gelatin shells contain ____ moisture

a)

13-16%

b)

10-12%

c)

15-18%

d)

18-20%

4.

It is best to choose the smallest capsule size that will accommodate the dose.

a)

True

b)

False

5.

Which of the following represents the right order of capsule shell manufacturing?

a)

Dipping - Drying - Stripping- Joining

b)

Dipping - Drying - Trimming - Stripping - Joining

c)

Dipping - Drying - Trimming- Joining

d)

Dipping - Drying - Stripping- Trimming - Joining

6.

Which excipient(s) can be used as diluent in the capsule formulation? Select All that Apply

a)

Magnesium Stearate

b)

Lactose

c)

Calcium Stearate

d)

Microcrystalline Cellulose (MCC)

7.

Hard gelatin shell material may contain an active substance.

a)

True

b)

False

8.

Soft gelatin capsules are suitable for drugs prone to oxidation

a)

True

b)

False

9.

Capsules can be stored in a freezer.

a)

True

b)

False

10.

Which of the following statements are TRUE about Capsules? Select all that apply

a)

Usually rapid released

b)

Solid dosage form

c)

Drug enclosed within either a hard or soft shell

d)

Primarily oral delivery

e)

Usually slow released

11.

Which of the following statements are TRUE about Gelatin? Select all that apply

a)

Protein prepared from hydrolysis of elastin

b)

Protein prepared from hydrolysis of collagen

c)

No Patient counselling

d)

Patient counselling

12.

Which of the following are TRUE about the properties of Gelatin? Select all that apply

a)

digested and absorbed

b)

stable when dry

c)

stable when wet

d)

subject to microbial degradation when moist

13.

We can say Gelatin come from animals.

a)

True

b)

False

14.

Which of the following are TRUE about why the use of Gelatin? Select all that apply

a)

Good strong, flexible, film -forming material

b)

Gelatin films are homogeneous in structure

c)

Non-toxic, edible and widely used in foodstuffs

d)

Readily soluble in biological fluids

e)

Reversibly change from solution to gel

15.

Which of the following types of Gelatin is derived from acid treated precursor   that exhibits an iso-electric point pH 9 and mainly from pork skin?

a)

Type A

b)

Type B

16.

Which of the following types of Gelatin Derived from alkali treated that exhibits an   iso-electric point at pH 4.7 and mainly from animal bones?

a)

Type A

b)

Type B

17.

Which of the following statements best describe the Gelatin Solubility?

a)

Insoluble in cold water, soften through the absorption of up to ten times its weight of water; soluble in cold water and in warm intestinal fluid.

b)

Insoluble in cold water, soften through the absorption of up to ten times its weight of water; soluble in hot water and in warm gastric fluid.

18.

Gelatin, being a protein, is digested by ______ enzymes in stomach.

a)

Protholytic

b)

Anfiobitic

19.

Which of the following Gelatin alternatives are available for patients who DO NOT consume animals? Select all that apply

a)

Starch, gluten, animal membranes, vegetable gelatin

b)

No options available for vegans

c)

Cellulose ethers

d)

Carrageen moss

20.

Hard capsules have shells consisting of 2 prefabricated, cylindrical sections, each of which has one rounded, closed end and one open end.

a)

True

b)

False

21.

Hard Gelatin Capsules are manufactured in one procedure and packed in another totally separate operation

a)

True

b)

False

22.

The active substance(s), usually in solid form (powder or granules), are filled into one (1) of the sections that is then closed by slipping the other section over it.

a)

True

b)

False

23.

The active substance of Hard Gelatin Capsules is usually in solid form (powder or granules).

a)

True

b)

False

24.

The security of the closure may be strengthened by suitable means.

a)

True

b)

False

25.

Hard Gelatin Capsules are made of gelatin, water and sugar and contains 13-16% moisture.

a)

True

b)

False

26.

Hard Gelatin Capsules are typically filled with dry solids and also contain Colorant (opacifants) and Preservatives.

a)

True

b)

False

27.

Which of the following are Ingredients of Hard Gelatin Shells? Select all that apply

a)

Plasticizer, Gelatin

b)

Opacifier, Colorants

c)

Wetting agents

d)

Demineralized water

e)

Flavors, Preservatives

28.

Which of the following statements are TRUE about the parameters when selecting a capsule size? Select all that apply

a)

The amount of fill material to be encapsulated

b)

Only by the result of trial

c)

The density and compressibility of the fill

d)

By the result of trial

29.

The sizes of empty capsules for human use ranges from 000 (the largest), 00, 1, 2, 3, 4, 5 (the smallest).

a)

True

b)

False

30.

The capacity of a capsule depends on the density and characteristics of the powders it contains.

a)

True

b)

False

31.

For immediate-release capsules, 100% active ingredient is the most desirable formula. However, it is rare that the dose required can be encapsulated without addition of a filler.

a)

True

b)

False

32.

I will use Technique #1 - Packing Method to choose the smallest capsule size.

a)

True

b)

False

33.

Which of the following techniques requires a simple subtraction of the weight of the active ingredient from the weight of filler that occupies 100% of the capsule?

a)

Technique #1 – Packing Method

b)

Technique #2 – Filler Weights

34.

Which of the following techniques means the bulk density of powders is approximately 0.6 g per milliliter, the size of the capsule can be approximated. According to the rule, the capsule sizes 0, 1, 2, 3, 4 and 5 can hold 6-7, 5, 4, 3, 2, and ½ to 1 grains of the powder, respectively. Each grain is approximately equivalent to 65 mg?

a)

Technique #1 – Packing Method

b)

Technique #2 – Filler Weights

c)

Technique #3 – Rules of Sixes

d)

Technique #4 – Powder Density

35.

In which of the following techniques one can use either a graduated cylinder or a tap Densimeter?

a)

Technique #1 – Packing Method

b)

Technique #2 – Filler Weights

c)

Technique #3 – Rules of Sixes

d)

Technique #4 – Powder Density

36.

The volume of the Densimeter cavity is one milliliter.

a)

True

b)

False

37.

Which of the following techniques may the compounder use after determine the density of powders by using either a graduated cylinder or a tap Densimeter?

a)

Technique #3 – Rules of Sixes

b)

Technique #2 – Filler Weights

c)

Technique #1 – Packing Method

d)

Not required to use any other technique

38.

Learn this order!

a)

Yes

b)

No

39.

Formulation Considerations

a)

Yes

b)

No

40.

Which of the following are considered formulation components? Select all that apply

a)

wetting agents

b)

diluent/filler

c)

disintegrants/disintegration agents

d)

lubricant or glidant

41.

A disadvantage of capsules is they're not suitable for highly soluble salts.

a)

True

b)

False

42.

Which of the following is a noninvasive procedure that entails the use of a gamma ray-emitting radiotracer incorporated into the formulation with a gamma camera coupled to a data recording system for IN VIVO tracking of capsules?

a)

Gamma Scintigraphy

b)

Delta Scintigraphy

43.

Which of the following is a is a pH sensitive radiofrequency transmitter encased in an inert , indigestible shell?

a)

Gamma Scintigraphy

b)

Heidelberg pH Capsule

44.

Soft gelatin capsules are made of gelatin, glycerin (or a polyhydric alcohol such as sorbitol) and water.

a)

True

b)

False

45.

Soft gelatin capsules are made to hermetically seal and encapsulate liquids, suspensions, pasty materials, dry powders and even preformed granules, pellets, tablets.

a)

True

b)

False

46.

Softgels may be manufactured to be oblong, oval or round in shape.

a)

True

b)

False

47.

Which of the following are TRUE about Softgels? Select all that apply

a)

may be manufactured as an oral dosage form

 

b)

They may be manufactured to be oblong, oval or round in shape.

c)

maybe manufactured as as a specialty package in tube form, for human and veterinary single dose application of topical, ophthalmic, and otic preparations, and rectal ointments.

d)

maybe manufactured as a suppository dosage form

e)

consist of a continuous gelatin shell surrounding a liquid core

48.

Shells of Softgels are softened by addition of glycerin or polyhydric alcohol (ex. sorbitol) and maybe manufactured oblong, spherical, elliptical in shape.

a)

True

b)

False

49.

Which of the following are formed, filled, and sealed in one operation?

a)

Softgels

b)

Tablets

50.

Soft capsules have thicker shells than those of hard capsules.

a)

True

b)

False

51.

Soft shells consist of a single part and are of various shapes.

a)

True

b)

False

52.

Soft shell material may contain an active substance.

a)

True

b)

False

53.

In which of the following capsules liquids can be enclosed?

a)

Softgels

b)

Hard Capsules

54.

Which of the following are TRUE about the Formulation Considerations for capsules? Select all that apply

a)
b)

Low temperature sensitivity

c)

Non-interaction with gelatin

d)

Low moisture sensitivity

55.

Plate, rotary die and reciprocating die are part of the manufacture process of capsules.

a)

True

b)

False

56.

Softgels has even more rapid release of contents and useful for drugs prone to oxidation.

a)

True

b)

False

57.

 

Softgels may contain liquids, suspensions, pastes.

a)

True

b)

False

58.

Softgels may increased possibility of interactions between drug and shell.

a)

True

b)

False

59.

Soft gelatin capsules are usually applied in the clinical trials.

a)

True

b)

False

60.

Which of the following statements are TRUE about the Containers (Storage Condition) of soft gels capsules? Select all that apply

a)

minimize the change of humidity

b)

minimize the change of temperature

c)

minimize the change by light

d)

maximize the change of temperature

61.

Protection from freezing, breakage of the shells, loss of strength or potency and physical change are all part of the storage condition of capsules.

a)

True

b)

False

62.

Which of the following are part of finished product quality control tests in the Evaluation of Capsules? Select all that apply

a)

Microbial content

b)

Permeability and sealing

c)

Average weight and weight variation

d)

Disintegration

and Dissolution

e)

Moisture content

63.

In process tests and finished product quality control tests are considered part of the Evaluation of Capsules.

a)

True

b)

False