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WorksheetsEXAM 1 CEUTICS II DR. YANG Capsules
Total questions: 63
Worksheet time: 1hrs 4mins
Capsules is a liquid dosage form if filled by oil.
True
False
Type B gelatin is mostly from pork skin.
True
False
Hard gelatin shells contain ____ moisture
13-16%
10-12%
15-18%
18-20%
It is best to choose the smallest capsule size that will accommodate the dose.
True
False
Which of the following represents the right order of capsule shell manufacturing?
Dipping - Drying - Stripping- Joining
Dipping - Drying - Trimming - Stripping - Joining
Dipping - Drying - Trimming- Joining
Dipping - Drying - Stripping- Trimming - Joining
Which excipient(s) can be used as diluent in the capsule formulation? Select All that Apply
Magnesium Stearate
Lactose
Calcium Stearate
Microcrystalline Cellulose (MCC)
Hard gelatin shell material may contain an active substance.
True
False
Soft gelatin capsules are suitable for drugs prone to oxidation
True
False
Capsules can be stored in a freezer.
True
False
Which of the following statements are TRUE about Capsules? Select all that apply
Usually rapid released
Solid dosage form
Drug enclosed within either a hard or soft shell
Primarily oral delivery
Usually slow released
Which of the following statements are TRUE about Gelatin? Select all that apply
Protein prepared from hydrolysis of elastin
Protein prepared from hydrolysis of collagen
No Patient counselling
Patient counselling
Which of the following are TRUE about the properties of Gelatin? Select all that apply
digested and absorbed
stable when dry
stable when wet
subject to microbial degradation when moist
We can say Gelatin come from animals.
True
False
Which of the following are TRUE about why the use of Gelatin? Select all that apply
Good strong, flexible, film -forming material
Gelatin films are homogeneous in structure
Non-toxic, edible and widely used in foodstuffs
Readily soluble in biological fluids
Reversibly change from solution to gel
Which of the following types of Gelatin is derived from acid treated precursor that exhibits an iso-electric point pH 9 and mainly from pork skin?
Type A
Type B
Which of the following types of Gelatin Derived from alkali treated that exhibits an iso-electric point at pH 4.7 and mainly from animal bones?
Type A
Type B
Which of the following statements best describe the Gelatin Solubility?
Insoluble in cold water, soften through the absorption of up to ten times its weight of water; soluble in cold water and in warm intestinal fluid.
Insoluble in cold water, soften through the absorption of up to ten times its weight of water; soluble in hot water and in warm gastric fluid.
Gelatin, being a protein, is digested by ______ enzymes in stomach.
Protholytic
Anfiobitic
Which of the following Gelatin alternatives are available for patients who DO NOT consume animals? Select all that apply
Starch, gluten, animal membranes, vegetable gelatin
No options available for vegans
Cellulose ethers
Carrageen moss
Hard capsules have shells consisting of 2 prefabricated, cylindrical sections, each of which has one rounded, closed end and one open end.
True
False
Hard Gelatin Capsules are manufactured in one procedure and packed in another totally separate operation
True
False
The active substance(s), usually in solid form (powder or granules), are filled into one (1) of the sections that is then closed by slipping the other section over it.
True
False
The active substance of Hard Gelatin Capsules is usually in solid form (powder or granules).
True
False
The security of the closure may be strengthened by suitable means.
True
False
Hard Gelatin Capsules are made of gelatin, water and sugar and contains 13-16% moisture.
True
False
Hard Gelatin Capsules are typically filled with dry solids and also contain Colorant (opacifants) and Preservatives.
True
False
Which of the following are Ingredients of Hard Gelatin Shells? Select all that apply
Plasticizer, Gelatin
Opacifier, Colorants
Wetting agents
Demineralized water
Flavors, Preservatives
Which of the following statements are TRUE about the parameters when selecting a capsule size? Select all that apply
The amount of fill material to be encapsulated
Only by the result of trial
The density and compressibility of the fill
By the result of trial
The sizes of empty capsules for human use ranges from 000 (the largest), 00, 1, 2, 3, 4, 5 (the smallest).
True
False
The capacity of a capsule depends on the density and characteristics of the powders it contains.
True
False
For immediate-release capsules, 100% active ingredient is the most desirable formula. However, it is rare that the dose required can be encapsulated without addition of a filler.
True
False
I will use Technique #1 - Packing Method to choose the smallest capsule size.
True
False
Which of the following techniques requires a simple subtraction of the weight of the active ingredient from the weight of filler that occupies 100% of the capsule?
Technique #1 – Packing Method
Technique #2 – Filler Weights
Which of the following techniques means the bulk density of powders is approximately 0.6 g per milliliter, the size of the capsule can be approximated. According to the rule, the capsule sizes 0, 1, 2, 3, 4 and 5 can hold 6-7, 5, 4, 3, 2, and ½ to 1 grains of the powder, respectively. Each grain is approximately equivalent to 65 mg?
Technique #1 – Packing Method
Technique #2 – Filler Weights
Technique #3 – Rules of Sixes
Technique #4 – Powder Density
In which of the following techniques one can use either a graduated cylinder or a tap Densimeter?
Technique #1 – Packing Method
Technique #2 – Filler Weights
Technique #3 – Rules of Sixes
Technique #4 – Powder Density
The volume of the Densimeter cavity is one milliliter.
True
False
Which of the following techniques may the compounder use after determine the density of powders by using either a graduated cylinder or a tap Densimeter?
Technique #3 – Rules of Sixes
Technique #2 – Filler Weights
Technique #1 – Packing Method
Not required to use any other technique
Learn this order!
Yes
No
Formulation Considerations
Yes
No
Which of the following are considered formulation components? Select all that apply
wetting agents
diluent/filler
disintegrants/disintegration agents
lubricant or glidant
A disadvantage of capsules is they're not suitable for highly soluble salts.
True
False
Which of the following is a noninvasive procedure that entails the use of a gamma ray-emitting radiotracer incorporated into the formulation with a gamma camera coupled to a data recording system for IN VIVO tracking of capsules?
Gamma Scintigraphy
Delta Scintigraphy
Which of the following is a is a pH sensitive radiofrequency transmitter encased in an inert , indigestible shell?
Gamma Scintigraphy
Heidelberg pH Capsule
Soft gelatin capsules are made of gelatin, glycerin (or a polyhydric alcohol such as sorbitol) and water.
True
False
Soft gelatin capsules are made to hermetically seal and encapsulate liquids, suspensions, pasty materials, dry powders and even preformed granules, pellets, tablets.
True
False
Softgels may be manufactured to be oblong, oval or round in shape.
True
False
Which of the following are TRUE about Softgels? Select all that apply
may be manufactured as an oral dosage form
They may be manufactured to be oblong, oval or round in shape.
maybe manufactured as as a specialty package in tube form, for human and veterinary single dose application of topical, ophthalmic, and otic preparations, and rectal ointments.
maybe manufactured as a suppository dosage form
consist of a continuous gelatin shell surrounding a liquid core
Shells of Softgels are softened by addition of glycerin or polyhydric alcohol (ex. sorbitol) and maybe manufactured oblong, spherical, elliptical in shape.
True
False
Which of the following are formed, filled, and sealed in one operation?
Softgels
Tablets
Soft capsules have thicker shells than those of hard capsules.
True
False
Soft shells consist of a single part and are of various shapes.
True
False
Soft shell material may contain an active substance.
True
False
In which of the following capsules liquids can be enclosed?
Softgels
Hard Capsules
Which of the following are TRUE about the Formulation Considerations for capsules? Select all that apply
Plate, rotary die and reciprocating die are part of the manufacture process of capsules.
True
False
Softgels has even more rapid release of contents and useful for drugs prone to oxidation.
True
False
Softgels may contain liquids, suspensions, pastes.
True
False
Softgels may increased possibility of interactions between drug and shell.
True
False
Soft gelatin capsules are usually applied in the clinical trials.
True
False
Which of the following statements are TRUE about the Containers (Storage Condition) of soft gels capsules? Select all that apply
minimize the change of humidity
minimize the change of temperature
minimize the change by light
maximize the change of temperature
Protection from freezing, breakage of the shells, loss of strength or potency and physical change are all part of the storage condition of capsules.
True
False
Which of the following are part of finished product quality control tests in the Evaluation of Capsules? Select all that apply
Microbial content
Permeability and sealing
Average weight and weight variation
Disintegration
and Dissolution
Moisture content
In process tests and finished product quality control tests are considered part of the Evaluation of Capsules.
True
False
