Chédiak Higashi is an autosomal recessive disease.

Deficiency in complement proteins C2 and C4 predisposes for fulminant meningococcal infection.

Wiskott-Aldrich syndrome is due to failure of immunologic synapse formation.

DiGeorge’s Syndrome results from developmental failure of the third and fourth pharyngeal pouches.

Quantity and quality of T cells are normal in Bruton’s agammaglobulinemia.

Patients with chronic granulomatous disease have phagocytes with defective intracellular killing capabilities.

Myeloperoxidase deficiency causes defective neutrophils function.

  Leukocyte adhesion syndrome-1 is characterized by defective integrin ligand (ICAM-1).

Chronic granulomatous disease leads to recurrent viral infection.

The most severe form of complement deficiency is that of C3.

The definitive treatment for SCID is stem cell transplantation.

Steroid induces immunosuppression mainly by sequestration of activated B lymphocytes in the peripheral reticuloendothelial system.

Acute allograft rejection is mediated by T but not B lymphocytes.

Chronic allograft rejection is characterized by narrowing of blood vessels’ lumen.

Hyperacute allograft rejection reaction is mediated by the recipient’s preformed anti-HLA antibodies.

Graft-versus-host disease (GVHD) is often seen in kidney transplantation.

Practically all transplantation centres would do allograft kidney transplant from living related donor if one-haplotype-is matched (or better).

In bone marrow transplantation (BMT) 6/6 HLA antigens should be matched.

Cyclosporin A and tacrolimus inhibit cytokine IL-2 transcription in T cells.

In reverse vaccinology scientists start by sequencing the genome of the organism.

Toxoid vaccines are prepared from bacterial endotoxins.

Conjugate bacterial vaccines are ‘whole organism’ inactivated vaccines.

‘Virus-like particles’ of human papilloma virus vaccine contain the viral genome.

COVID-19 accelerated vaccine development means scientists went directly to clinical trials and omitted doing preclinical trials.