WorksheetsIntroduction to Biopharmaceutics
Total questions: 15
Worksheet time: 11mins
In pharmacokinetics what does the acronym ADME stand for?
adsorption, distribution, metabolism and excretion
absolute, distribution, metastasis and excretion
absorption, distribution, metabolism and excretion
absorption, distillation, metabolism and excretion
Applications of pharmacoki-
netics studies include:
bioavailability measurements
all of these
correlation of pharmacological responses with
administered doses
effects of physiological and pathological con-
ditions on drug disposition and absorption
· dosage adjustment of drugs in disease states, if
What is the range of Tobramycin (Nebcin, Tobrex)?
4–8 mg /L
4-12 mg/L
5-12 mg/L
None of these
What are the steps involved in developing a new drug ?
Preclinical research
& Investigational New Drug (IND) Application
Phase 1 trials
& Phase II trials
Phase III trials ,
New Drug Application (NDA)
& Approval
All of these
Which of the following is the correct definition of bioavailability?
Bioavailability describes the proportion of the drug administered that is metabolised very quickly and thus is not available to induce a physiological effect.
Bioavailability describes the ability of the administered drug metabolites to cause undesirable physiological effects.
Bioavailability is used to describe the fraction of the dose of drug administered that is present within the body and facilitates the desired physiological effects.
Bioavailability is the length of time an administered drug is present in the body and thus is available to cause a physiological effect.
Elimination is
Absorption and metabolism
Distribution and metabolism
Metabolism and excretion
Distribution and excretion
The time the drug concentration is above the MEC.
Elimination
Absorption
Duration of action
Dosposition
The transfer of a drug out of a dosage form and into the blood is called
Absorption
Metabolism
Elimination
Dissolution
The time MEC is reachedc and the response occurs.
site of action
Therapeutic window
Onset of action
None of above
The rate and extent of drug distribu-
tion is determined by:
how well the tissues and/or organs are perfused
with blood
the binding of drug to plasma proteins and
tissue components
the permeability of tissue membranes to the
drug molecule.
For the calculation of the volume of distribution (vd) one must take :
Concentration of a substance in plasma
A daily dose of drug
Concentration of substance in urine
Therapeutical width of drug action
What is the unit of volume of distribution?
mg
mg/L
L
Cm
What is Vd for total body water?
40
3
17
77
77 is volume of distribution for ____________
Atenolol
Digoxin
Felodipine
Diazepam
Reasons for the variation in concentration of drug distribution are:
Tissue differences in rates of uptake of drugs: Blood flow and capillary permeability
Differences in tissue/blood ratios at equilibrium: Dissolution of lipid-soluble drugs in adipose tissue, binding of drugs to intracellular sites, and plasma protein binding
Apparent volume of distribution (Vd)
