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GI 1 pharm

Total questions: 38

Worksheet time: 22mins

Name
Class
Date
1.

drug only indicated for women?

a)

lubiprostone

b)

alosetron

c)

psyllium

d)

tegaserod

e)

loperamide

2.

which drug is indicated for IBS-C

a)

dicyclomine

b)

colestipol

c)

alosetron

d)

linaclotide

3.

which drug is not indicated for IBS-C?

a)

psyllium

b)

polyethylene glycol

c)

tegaserod

d)

linaclotide

e)

lopermide

4.

which drug is a bile acid sequestrant indicated for IBS-D?

a)

colestipol

b)

losartan

c)

rifaximin

d)

alosetron

e)

eluxadoline

5.

moderate, persistant IBS-D could be treated with?

a)

loperamide

b)

dicyclomine

c)

hypscyamine

d)

alosetron

e)

eluxadoline

6.

a pt with severe persistant IBS-D could be treated with?

a)

alosetron

b)

colestipol

c)

eluxadoline

d)

PEG

7.

BBW with lopermide?

a)

QT interval elongation

b)

tardative dyskinesia

c)

psych issues in children when used chronically

d)

respiratory depression in children < 2yo

8.

which IBS-D drug is contraindicated in alcholics and history of cholecystectomy ?

a)

loperamide

b)

alosetron

c)

eluxadoline

d)

rifaximin

9.

what IBS-D drug can cause torsades de pointes?

a)

loperamide

b)

colestipol

c)

hyoscyamine

d)

alosetron

10.

which antibacterial drug is used in IBS-D?

a)

loperamide

b)

PEG

c)

refaximin

d)

dicyclomine

e)

alosetron

11.

which drugs are antispasmodics?

a)

dicycylomine

b)

hyoscyamine

c)

rifaximin

d)

eluxadoline

12.

Amitripyline

a)

indicated for IBS-D and IBS-C

b)

anticholinergic

c)

tricyclic antipressant

d)

can cause constipation, caution in IBS-C

13.

a pt with moderate, persistant IBS-C could be treated with?

a)

PEG

b)

lubiprostone

c)

linaclotide

d)

dicyclomine

e)

hyoscyamine

14.

what drug is reserved for severe IBS-C pts?

a)

tegaserod

b)

psyllium

c)

linaclotide

d)

lubiprostone

15.

tegaserod is in ________ drug class and indicated for IBS- _

a)

5-HT4 agonist, C

b)

osmotic agent, D

c)

guanylate cyclase agonist, C

d)

5-HT4 agonist, D

16.

which drug is matched incorrectly with its drug class?

a)

tegaserod- 5HT4 agonist

b)

linaclotide- guanylate cyclase agonist

c)

amitriptyline- tricyclic antidepressent

d)

colestipol- bile acid sequestrant

e)

alosetron- antispasmodic

17.

which drug is matched incorrectly with its drug class?

a)

rifazimin- antibacterial

b)

hyoscyamine- antispasmodic

c)

alosteron- 5HT3 antagonist

d)

lopermide- bile acid sequestrant

e)

polyethylene glycol- osmotic agent

18.

antispasmodics cause

a)

short term relief

b)

long term relief

19.

5-HT3 antagonist that locks serotonin binding to receptor

a)

alosetron

b)

lopermide

c)

tegaserod

d)

linaclotide

20.

treatment for chemo induced n/v regimine includes

a)

Aprepitant

b)

dexamethasone

c)

serotonin HT3-receptor antagonists

d)

antihistamine

21.

a 27 yo G2P1001 complains of persistant nausea and vomiting despite diet changes and ginger/ vitamin B6 use. She does not show signs of dehydration. what is appropriate treamtnent?

a)

ondansetron

b)

promethazine

c)

lifestyle modifications

d)

pyridoxine +/- doxylamine

22.

drugs that are recommended in pregnancy for persistant n/v without dehydration?

a)

diphenhydranine

b)

pyridoxine

c)

doxylamine

d)

metoclopramide

e)

graniestron

23.

what is recommended treatment for hyperemesis gravidarum?

a)

pyridoxine + doxylammine

b)

diphenhydramine

c)

promethazine

d)

PEG

24.

promethazine BBW

a)

pediatric respiratory depression

b)

black tongue

c)

spontaneous abortions due to uterine sloughing

d)

qt interval prolongation

25.

NK1 receptor antagonist

a)

blocks activity of substance P

b)

Aprepitant

c)

induces warfarin

d)

commonplace in cemotherapy induced n/v

26.

antidopaminergics

a)

metoclopramide

b)

promethazine

c)

diphenhydramine

d)

meclizine

27.

antihistamines

a)

diphenhydramine

b)

dimenhydrinate

c)

meclizine

d)

metoclopramide

e)

promethazine

28.

graniestron, ondansetron, dolasetron, palonestron, and alosetron are drugs within what class?

a)

5-HT3 antagonist

b)

antidopaminergics

c)

antihistamines

d)

NK1

29.

which 5-HT3 antagonist is most likely to cause QT interval prolongation?

a)

granisetron

b)

dolasetron

c)

palonosetron

d)

alosetron

30.

which H2RA has most drug interactions?

a)

cimetidine

b)

famotidine

c)

ranitidine

d)

nizatidine

31.

H2RAs have ______ binding to histamine receptors

a)

reversible

b)

irreversible

32.

OTC antacids that can cause kidney impairment?

a)

alka seltzer

b)

Rolaids

c)

tums

d)

maalox

33.

Aluminum causes ______ and magnesium causes ______

a)

constipation, diarrhea

b)

diarrhea, constipation

34.

MOA: inhibit the pumping of HCl out of parietal cells

a)

PPIs

b)

H2RAs

c)

antacids

d)

bile acid sequestrants

35.

PPI with most drug interactions?

a)

omeprazole

b)

lansoprazole

c)

esomeprazole

d)

pantoprazole

36.

taken 3/4 times daily

a)

misoprostol

b)

sucralfate

c)

metoclopramide

d)

domperidone

37.

drug that can cause spontaneous abortions due to utrine sloughing?

a)

misoprostol

b)

sucralfate

c)

omeprazole

d)

metoclopramide

38.

which drug is matched incorrectly with its ADE?

a)

misoprostol- spontaneous abortion

b)

sucralfate- constipation

c)

metoclopermine- tardative dyskinesia

d)

dopermidone- increase prolactin

e)

H2RA- constipation

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