WorksheetsImmunology Chapter 5 (pt. 2)
Total questions: 28
Worksheet time: 14mins
Select the statement about secondary response to an antigen that is true.
Equal amounts of IgM and IgG are made.
IgG is increased 100-fold to 1,000-fold
IgM is increased 100-fold
The lag time is the same as the primary response
Which statement is not true about class switching?
A portion of the constant region DNA is deleted and the remaining CH genes are placed adjacent to the variable region genes.
The same VDJ region is coupled with a different C region to produce antibody of a different class.
New antibodies have different specificities for antigens.
Switching is determined by contract with T cells.
Which of the following statements about coding for antibody molecules is true?
Heavy chains are coded for on chromosome 2.
V, D, and J code for heavy chain variable regions.
DNA molecules coding for light chains are rearranged first.
V and D code for light chain variable regions.
Immunoglobulins are grouped into classes on the basis of similarities in:
light chains
heavy chains
antigen-binding sites
disulfide bonds
What is the main function of IgD?
it helps in class switching
it is a primary response antibody
it protects mucous membranes
it offers protection to newborns
When B cells change to the production of a different antibody isotype that is more effective in defending the host against a particular type of microbe, this is called:
transcription
production of monoclonal antibodies
class switching
antigen presentation
Which class makes up 70% to 80% of total serum immunoglobulins?
IgA
IgG
IgM
IgE
Which option best describes a monoclonal antibody?
antibody made against multiple epitopes
antibody made by a variety of B cells
antibody made from a single antibody-producing cell
all antibodies of any one particular class
Which antibody is best able to agglutinate and fix complement?
IgA
IgM
IgG
IgE
Immunoglobulins IgG, IgM, IgA, and IgD represent:
isotypes
allotypes
idiotypes
heterotypes
An Fab fragment consists of:
two heavy chains
two light chains
one light chain and one-half of a heavy chain
one light chain and an entire heavy chain
Which immunoglobulin causes allergic reactions because of release of histamine from mast cells?
IgA
IgE
IgD
IgM
Identify the main purpose of the secretory component of IgA.
Transports across endothelial cells
Combines with antigen
Joins the two comomers
Involved in class switching
Identify the characteristic that best describes IgE.
fixes complement
binds to mast cells
found on mucosal surfaces
participates in agglutination reactions
In serum electrophoresis conducted at pH 8.6, which protein group migrates the fastest?
Albumin
Alpha-1 globulin
Alpha-2 globulin
Gamma globulin
The antibody that appears first in an immune response and is a pentamer with a molecular weight of 900,000 Da best describes:
IgM
IgD
IgA
IgG
The antibody found on B cells that is thought to be involved in B-cell maturation is:
IgA
IgD
IgE
IgM
The theory that lymphocytes are preprogrammed to respond to a particular type of antigen best describes:
the clonal selection theory
Ehrlich's side-chain theory
the spontaneous generation theory
Edelman's antibody-formation theory
In serum protein electrophoresis, which band contains most of the immunoglobulins?
Alpha-1
Alpha-2
beta
gamma
Which of the following best characterized IgD?
Primary response antibody
surface receptor for antigen
responsible for allergic reactions
fixes complement
Where on an antibody molecule does combination with antigen take place?
Variable region
constant region
hinge region
Fc region
Which antibody is found mainly as a dimer in mucosal secretions?
IgA
IgD
IgE
IgG
How does IgG differ from IgM?
IgM can cross the placenta
IgG can bind more antigens than IgM.
IgG is the main antibody in serum
only IgM has happa light chains
IgG subclasses differ from one another in the number and position of:
heavy chain domains
antigen-binding sites
light chains
disulfide bonds
Of all IgG subclasses, IgG3 has the largest hinge region, making it:
the only subclass capable of crossing the placenta.
the subclass with the highest number of antigen-binding sites.
the most efficient subclass for activation complement
incapable of opsonization
Which of the following methods does not use monoclonal antibodies?
the indirect antiglobulin test
pregnancy testing
testing for T helper cell concentration
testing for immunodeficiencies
Breast cancer, non-Hodgkin lymphoma, and B-cell malignancies can all be treated with:
cross-reactivity
adoptive immune therapies
monoclonal antibodies
toxoids
Monoclonal antibodies can be generated by hybridoma cell lines produced by using spleen cells from which animal?
sheep
horses
goats
mice
