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Justoza Neev Program Quiz

Total questions: 23

Worksheet time: 23mins

Name
Class
Date
1.

NAME

4 lines
2.

HQ

4 lines
3.

REGION

4 lines
4.

Drug Master File (DMF) is a submission to the Food and Drug Administration (FDA) about the ___________________, processing, packaging, and storing of one or more human drugs.

a)

Taxonomy

b)

Manufacturing

c)

Purification

d)

All of the above

5.

DMF grade API for formulation comes from ___________________________certified plants

a)

USFDA

b)

EUGMP

c)

WHO

d)

All of the Above

6.

Kidneys reabsorb Glucose via which of the following transporters? (More than 1 Answer)

a)

GLUT-4

b)

GLUT-2

c)

SGLT-1

d)

SGLT-2

7.

DAPA HF Trial had _____% pts who were Diabetic

a)

44%

b)

42%

c)

45%

d)

43%

8.

Justoza provides ______% reduction in NTproBNP post 8 month of treatment

a)

22

b)

23

c)

21

d)

24

9.

Increased Renal Glucose ___________________ May Contribute To Hyperglycemia In Diabetes.

a)

Reabsorption

b)

Excretion

c)

Secretion

d)

All of the above

10.

SGLT2 Inhibitors _________________Renal Threshold for Glucose Excretion (RTG)

a)

Decrease

b)

Increase

11.

SGLT-2i offer which of the following benefits. (More than 1 options can be correct)

a)

Excess of Glucose is excreted through the Urine

b)

Caloric Loss- Loss of Weight

c)

Reduction in BP

d)

Unique Insulin independent MOA

12.

Dapagliflozin reduces CV Mortality by ___________% as per DAPA-HF

a)

25

b)

36

c)

18

d)

27

13.

Dapagliflozin causes Hypoglycemia similar to Insulin

a)

True

b)

False

14.

In patients with heart failure (NYHA II-IV) with reduced ejection fraction _______________reduces the risk of CV death and hospitalization for heart failure as per DAPA-HF Trial?

a)

ARNI

b)

Dapagliflozin

c)

Canagliflozin

d)

All of the above

15.

Justoza is recommended by _______________as first line therapy in T2DM with CKD & HF

a)

AHA Guidelines 2022

b)

ADA Guidelines 2022

c)

ACC Guidelines 2022

16.

In patients with T2DM with established CVD or multiple CV risk factors, to reduce the risk of hospitalization for Heart Failure dapagliflozin was approved as per which trial?

a)

DAPA HF

b)

DAPA-CKD

c)

DECLARE TIMI 58

d)

All of the Above

17.

As per the VA, Dapagliflozin is now indicated as Component of First-line therapy in HFrEF patients as per ____________________________. 

a)

2021 ACC Expert Consensus Decision Pathway.

b)

ESC HF 2021 Guidelines

c)

ACC HF 2021 Guidelines

d)

All of the above

18.

As per Dapa HF Study In HFrEF patients without Diabetes, Dapagliflozin showed _____% reduction in primary composite End point of CV death or Heart Failure Hospitalization

a)

24

b)

27

c)

25

d)

26

19.

As per Dapa HF Study In HFrEF patients without Diabetes, Dapagliflozin showed _____% reduction in Hospitalization for Heart Failure

a)

38

b)

37

c)

39

d)

40

20.

Justoza10 mg costing –

a)

Rs. 9.90/tab

b)

Rs. 7.50/tab

c)

Rs.10.95 /tab

21.

Justoza 5mg costing –

a)

Rs. 9.90/tab

b)

Rs. 7.50/tab

c)

Rs.10.95 /tab

22.

Declare-TIMI trial, the largest CVOT with an SGLT2i conducted on  T2DM patients showed that in primary prevention patients, Dapagliflozin reduced the risk of HHF by ___________.

a)

44%

b)

26%

c)

36%

d)

32%

23.

The Primary Composite Outcome of which trial is reduction in Sustained ≥50% eGFR Decline, ESKD, Renal or CV Death? 

a)

DAPA-HF

b)

DAPA-CKD

c)

DECLARE-TIMI