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WorksheetsMI 3.4.1 Quiz Review (Quizizz)
Total questions: 15
Worksheet time: 8mins
An SNP profile is
the single-base difference in one gene between one individual and another individual.
the single-base pair differences in 2 or more genes.
the mutation in a gene that causes certain diseases.
the haplotype pair an individual possesses.
the sequence of DNA that allows for primer extension.
The field of research that concerns itself with learning the individual patient's genetic profile in order to determine the best course of drug treatment is specifically termed
pharmacogenetics.
precision medicine
haplotypes.
ALL.
thiopurine methyltransferase.
Which of the following is not a reason that makes personalized or precision medicine more of a realistic treatment option today?
Computer processing times are getting faster and large networks allows for doctors to share research data.
Costs of implementation is getting lower.
The human genome is getting less complicated and therefore, very easy to sequence which only takes a few hours now.
DNA sequence technology has drastically improved.
Computer software is getting better at analyzing massive amounts of DNA data.
Response to azathioprine, a chemotherapy drug used to treat ALL (a form of leukemia), depends on
which stage of ALL that patient is in.
if the patient has a specific SNP at an oncogene.
how early TPMT treatment is started.
the dose of TPMT given in conjunction with azathioprine.
a patient's level of TPMT activity.
Personalized medicine for a specific patient factors in all of the following except
age.
computer used in analysis.
genetics.
diet.
environmental factors.
Cancer of the white blood cells is referred to as
melanoma.
osteosarcoma.
actinic keratosis.
acute lymphoblastic leukemia.
A haplotype is
a single-base substitution in a region of DNA that is different from another genetic profile.
a person's reaction to a drug.
a combination of single-base substitutions in a region of DNA that is different from another genetic profile..
a pair of chromosomes that we inherit from both of our parents.
Thiopurine methyltransferase or TPMT
is an enzyme produced by the body that breaks down azathioprine, preventing toxic levels to build up.
is a chemotherapy drug that attacks cancer cells.
is a drug that stops DNA replication in all cells.
is a type of drug that relieves symptoms of asthma only in people with certain SNP profiles.
Refer to the DNA sequences below:
DNA sample from patient:
From chromosome region (from mother)
GGATTACAAT
CCTAATGTTA
From chromosome region (from father)
GGATGACATT
CCTACTGTAA
The pair of DNA sequences above (both from the same patient) found on homologous chromosomes would be referred to as
an SNP.
a SNP profile.
a haplotype.
a genome.
How are scientists able to tell the difference between two different SNPs using PCR and gel electrophoresis?
A primer that matches one of the SNPs perfectly will continue to extend the sequence which will be longer and appear as a larger fragment on a gel.
Both DNA samples with the different SNPs will be copied but one of the SNPs will only be copied half as much and will appear lower on a gel.
Both DNA samples with the different SNPs will be copied but one of the SNPs will be copied doubled the amount as the other SNP sample and appear darker on a gel.
A primer will cut and destroy one of DNA samples with a particular SNP and will not show up on a gel at all.
The GeneSight test evaluates the genetic variations that may affect how one responds to ________________ and has lead to __________________.
antidepressants; reduced prescriptions and lower costs
antibiotics; increased effectiveness in fighting infections
chemotherapy; decreased negative side effects
vaccinations; increased boost in immunity
Personalized diets can be developed for patients with diabetes by examining
diabetic medication levels in the blood and designing the best dosages that interact with food.
epidemiological studies of the cultural and ethnic influences in food.
bioinformatic data on pancreatic enzymes such as insulin for each patient when exposed to different foods.
the glycemic response to different foods, using a computer algorithm and analyzing individual genetic profiles.
DNA sequencing and molecular profiling of bacterial, fungal and viral pathogens
is the only way to cure the infection.
can help reduce treatment costs.
can design treatments that are most effective against a particular strain or species of pathogens.
can reduce the negative side effects of drug treatment.
Precision medicine currently involved in cancer therapies include
creating bionic cells that will circulate in the bloodstream and destroy cancer cells with radiation.
drugs that target specific cell surface markers of cancer cells.
analyzing genetic profiles using computers and inserting a microchip in patients that will electrify cancer cells.
boosting individual immune systems to attack cancer cells.
Precision medicine can help in the field of regenerative medicine by
combining engineering, materials science and 3D printing in creating replacement organs.
coaxing the patients own stem cells into forming damaged or missing tissues that normally cannot on its own.
reducing the patient's immune response in rejecting implanted engineered tissues.
creating super bacteria that manufactures engineered organs in cloned animals that can be transplanted in humans.
