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WorksheetsCarcinogenesis quiz
Total questions: 16
Worksheet time: 3mins
First described association of a chemical carcinogen to a cancer was
Asbestos to lung cancer
Alkylating agents to leukemia
Coal/ soot to scrotal cancer
Aniline dyes to bladder cancer
Initiators do not cause permanent DNA damage
True
False
Anti cancer drugs are examples of
Directly acting carcinogens
Indirectly acting carcinogens
Promotors
Ultimate carcinogens
DIRECTLY ACTING carcinogens are more potent compared to indirectly acting carcinogens
True
False
Most indirect carcinogens are detoxified by
P120 dependent monooxygenases
Myeloperoxidsase
Alpha 1 anti trypsin
P450 dependent monooxygenases
The chemical carcinogen present in Smoked fish / meat are
Directly acting carcinogen
Promotors
Indirectly acting carcinogen
Alkylating agents
All are examples of indirectly acting carcinogens except
POLYCYCLIC AND HETEROCYCLIC AROMATIC HYDROCARBONS
Aflatoxin B1
Benzidine
Phenol
Aflatoxin B1 causes
Hepatocellular carcinoma
Hepatoblastoma
Cholangiocarcinoma
Hepatic adenoma
Hormones causes
Initiation
Direct DNA damage
Promotion
Epigenetic alterations
Example of fungal carcinogen
Aspergillus
Mucormycosis
Candida albicans
Cryptococcus
Most potent mutagen is ( Which is filtered by ozone)
UV A
UV B
UV C
RF
UV exposure leads to
Point mutation
Formation of pyramidine dimers
Epigenetic alteration
P53 supression
HTLV-1 infects
CD4 cells
CD 8 cells
B cells
NK cells
HTLV 1 contains __________ gene that encodes a protein resulting in carcinogenesis
LMP 1
E6
Tax
E7
High risk types of HPV are
16,18
6,11
1,2
11,14
EBV can cause Nasopharyngeal carcinoma
True
False
