Worksheetsbiochme-final-5
Total questions: 48
Worksheet time: 24mins
Name
Class
Date
1.
1. 有關 ibuprofen 之作用機轉為何者為是?
a)
A. 抑制 mucin 分泌
b)
B. 抑制發炎反應
c)
C. 抑制 COX-1 與 COX-2
d)
D. 以上皆是
e)
E. 以上皆非
2.
2. 下列何者會增加 triacylglycerol 的合成?
a)
(A). insulin
b)
(B). glucagon
c)
(C). epinephrine
d)
(D). 以上皆是
3.
3. Glucose 與Na2+ 在 intestinal epithelial cells 的運输方式為何?
a)
(A). uniporter
b)
(B). symporter
c)
(C). antiporter
d)
(D). 以上皆是
e)
(E). 以上皆非
4.
4. Glucose 經由 GLUT2 進入 blood 的運輸方式為何?
a)
(A). uniporter
b)
(B). symporter
c)
(C). antiporter
d)
(D). 以上皆是
e)
(E). 以上皆非
5.
5. 有關 chloride-bicarbonate exchanger 下列敘述何者為是?
a)
(A). cotransport
b)
(B). antiporter
c)
(C). carbonic anhydrase 參與
d)
(D). 以上皆是
e)
(E). 以上皆非·
6.
6-8 題.請排列出fatty acid synthesis 的順序: (1) Condensation (2) reduction of carbonyl to hydroxyl (3) dehydration of alcohol to alkene (4) reduction of alkene to alkane (5) chain transfer (6) recharging of ACP (7) elimination of O2
a)
(A). 123456
b)
(B). 132546
c)
(C). 123457
d)
(D). 132547
e)
(E). 123467
7.
9. Malonyl-CoA 之合成與下列何者無關?
a)
(A). acetyl-CoA
b)
(B). biotin
c)
(C). CO
d)
(D). bicarbonate
e)
(E). 以上皆有關
8.
10. 有關 Na+K+ ATPase 的敘述何者為是?
a)
(A). 2 個 Na+換 3 個 K+
b)
(B). 藉由碳酸化與去磷酸化來改變構形
c)
(C). 屬於 symport system
d)
(D). 不需要 ATP
e)
(E). 以上皆非
9.
11. 下列有關 simvastatin 的敘述何著錯誤?
a)
(A). 會增加乳酸合成
b)
(B). 屬於 HMG-CoA reductase inhibitor
c)
(C). 會增加 coenzyme Q 含量
d)
(D). 以上皆是
e)
(E). 以上皆非
10.
12. Cortisol elevate blood sugar 的敘述何者有誤?
a)
(A). 減少 PEPCK expression in liver
b)
(B). 增加 gluconeogenesis
c)
(C). 增加脂肪酸 released into blood
d)
(D). 增加血糖
e)
(E). 以上敘述皆正確
11.
13. Cholesterol 是下列何種 Vitamin 合成的前驅物?
a)
(A). K
b)
(B). E
c)
(C). D
d)
(D). 以上皆非
e)
(E). 以上皆是
12.
14. 下列何著與合成 cholesterol 無關?
a)
(A). Cyclase
b)
(B). Squalene monooxygenase
c)
(C). NADPH
d)
(D). 以上皆無關
e)
(E). 以上皆有關
13.
15. 有關 cholesterol synthesis 的順序何者正確? (1) condensation (2) conversion (3) polymerization (4) cyclization
a)
(A). 3241
b)
(B). 2134
c)
(C). 1234
d)
(D). 2143
e)
(E). 以上皆非
14.
16. 關於活化 peroxisome proliferator-activated receptorγ(PPARγ)的敘述何者有誤?
a)
(A). 增加 resynthesis of triacylglycerol in adipose tissue
b)
(B). promote sensitivity to insulin
c)
(C). induces the activity of PEP carboxykinase
d)
(D). 增加 glyceroneogenesis
e)
(E). 以上敘述皆正確
15.
17. 能活化之 PPARγ 化合物具有何種特性?
a)
(A). 可用來治療 type 2 diabetes
b)
(B). 例如 pioglitazone
c)
(C). 屬於 thiazolidinedione
d)
(D). 以上敘述皆錯誤
e)
(E). 以上敘述皆正確
16.
18. 下列何者與合成 triacylglycerol 無關?
a)
(A). diacylglycerol 3-phosphate
b)
(B). glycerol kinase
c)
(C). fatty acyl-CoA
d)
(D). 以上皆有關
e)
(E). 以上皆無關
17.
19. 下列何者與 triacylglycerol cycle 無關
a)
(A). dihydroxyacetone phosphate
b)
(B). glycerol 6-phosphate
c)
(C). oxaloacetate
d)
(D). pyruvate
e)
(E). 以上皆無關
18.
20. 何者非 cholesterol 的衍生物?
a)
(A). squalene
b)
(B). estradiol
c)
(C). progesterone
d)
(D). cholesteryl ester
e)
(E). 以上皆是
19.
21. 關於 aldosterone 之敘述下列何者錯誤？
a)
(A). 非 steroid hormone
b)
(B). 屬於 mineralcorticoid
c)
(C). 參與 HCO3-與 Cl-的再吸收
d)
(D). 以上敘述皆錯誤
e)
(E). 以上敘述皆正確。
20.
22. 有關 HMG-CoA reductase 的調控何者錯誤？
a)
(A). insulin promotes dephosphorylation (activation)
b)
(B). glucagon promotes phosphorylation (inactivation)
c)
(C). oxysterol stimulate proteolysis
d)
(D). 以上敘述皆正確
e)
(E). 以上敘述皆錯誤。
21.
23. 下列何者與合成 mevalonate 無關？
a)
(A). HMG-CoA synthase
b)
(B). ATP
c)
(C). HMG-CoA reductase
d)
(D). HMG-CoA
e)
(E). 以上皆與合成 mevalonate 有關。
22.
24. 下列何者與 acetyl-CoA 之運送無關？
a)
(A). citrate
b)
(B). citrate synthase
c)
(C). acetyl-CoA transporter
d)
(D). citrate lyase
e)
(E). 以上皆有關。
23.
25. 關於 prostaglandin 合成之敘述下列何者有關？
a)
(A). phospholipase A2
b)
(B). cyclooxygenase
c)
(C). arachidonate
d)
(D). 以上皆有關
e)
(E). 以上皆無關。
24.
26. Arachidonic acid 轉變 leukotriene 需要何種酵素？
a)
(A). acyl transferase
b)
(B). acetyl-CoA carboxylase
c)
(C). lipoxygenase
d)
(D). malic enzyme
e)
(E). 以上皆非
25.
27. 催化合成 malonyl-CoA 的酵素為何？
a)
(A). acyl transferase
b)
(B). acetyl-CoA carboxylase
c)
(C). lipoxygenase
d)
(D). malic enzyme
e)
(E). 以上皆非
26.
28. 何酵素參與 NADPH 的產生？
a)
(A). acyl transferase
b)
(B). acetyl-CoA carboxylase
c)
(C). lipoxygenase
d)
(D). malic enzyme
e)
(E). 以上皆非
27.
29. 酵素與合成 phosphatidic acid 有關？
a)
(A). acyl transferase
b)
(B). acetyl-CoA carboxylase
c)
(C). lipoxygenase
d)
(D). malic enzyme
e)
(E). 以上皆非
28.
30. Pentose phosphate pathway 與下列何者有關？
a)
(A). NADPH
b)
(B). Glucose 6 phosphate
c)
(C). 蠶豆症
d)
(D). 以上皆有關
e)
(E). 以上皆無關
29.
31. Ubiquitin is a small protein which is covalently linked to proteins designated for destruction via
a)
(A). ATP-dependent proteases in lysosomes
b)
(B). ATP-dependent proteases in ribosomes
c)
(C). ATP-dependent proteases in proteasomes
d)
(D). ATP-dependent proteases in endosomes
e)
(E). ATP-dependent proteases in peroxisomes
30.
32. Amino acids are not stored in appreciable concentrations. However, what amino acids would be found in significant concentration in blood of an intense workout person in a gym?
a)
(A). Alanine
b)
(B). Cysteine
c)
(C). Glutamate
d)
(D). Histidine
e)
(E). Proline
31.
33. What is the major organ for amino acids catabolism in mammals?
a)
(A). Brain
b)
(B). Liver
c)
(C). Small intestine
d)
(D). Bone marrow
e)
(E). Skeleton muscles
32.
34. Which two amino acids can be directly converted each other by a single biochemical reaction?
a)
(A). Glutamine and asparagine
b)
(B). Alanine and glycine
c)
(C). Leucine and isoleucine
d)
(D). Phenylalanine and tyrosine
e)
(E). Tryptophan and alanine
33.
35. What will be general diet advice for the patient with defects in amino acids catabolism?
a)
(A). Low glucose drink
b)
(B). Low fat diet
c)
(C). Low fiber diet
d)
(D). Low starch diet
e)
(E). Low protein diet
34.
36. X+α-ketoglutarate→pyruvate+Y, in this transamination reaction, which one is correct?
a)
(A). X=aspartate
b)
(B). X=glutamine
c)
(C). Y=oxaloacetate
d)
(D). Y=glutamate
e)
(E). Y=alanine
35.
37. Which one is wrong about excess arginine supplementation for treating Urea Cycle Disorders?
a)
(A). Activates N-acetylglutamate synthase
b)
(B). Increases the rate of urea production
c)
(C). Increases aspartate production
d)
(D). Increases carbomyl phosphate synthetase I activity
e)
(E). Increases nitrogen excretion
36.
38. Which reaction is NOT happened in mitochondria?
a)
(A). Aspartate aminotransferase
b)
(B). Argininosuccinate synthetase
c)
(C). Glutamate dehydrogenase
d)
(D). Ornithine transcarbamylase
e)
(E). Carbomyl phosphate synthetase I
37.
39. Which compound is NOT one-carbon carrier in metabolism?
a)
(A). Tetrahydrobiopterin
b)
(B). Formyl-tetrahydrofolate
c)
(C). Methyl-tetrahydrofolate
d)
(D). Biotin
e)
(E). S-adenosylmethionine
38.
40. Which enzyme is NOT related to ammonium assimilation in bacteria?
a)
(A). Arginase
b)
(B). Glutamine synthetase
c)
(C). Glutamate synthase
d)
(D). Glutamate dehydrogenase
e)
(E). Nitrogenase
39.
41. Which one cannot use succinyl-CoA for its catabolism of carbon skeleton?
a)
(A). Methionine
b)
(B). Leucine
c)
(C). Isoleucine
d)
(D). Valine
e)
(E). Threonine
40.
42. Which of the following amino acids belong to both ketogenic and glucogenic ? (a) Phe (b) Trp (c) Ile (d) Arg (e) Met
a)
(A). acd
b)
(B). abc
c)
(C). bcd
d)
(D). bde
e)
(E). ace
41.
43. Branched-chain amino acids can be used as alternative energy in skeleton muscle. What disease is associated with the metabolic deficiency?
a)
(A). albinism
b)
(B). phenylketonuria
c)
(C). homocystinuria
d)
(D). methylmalonic acidemia
e)
(E). maple syrup urine disease
42.
44. According to the lecture, which enzyme could be used as a gene therapy target for leukemia patients?
a)
(A). glutamate dehydrogenase
b)
(B). glutamine synthetase
c)
(C). alanine aminotransferase
d)
(D). asparaginase
e)
(E). phenylalanine hydroxylase
43.
45. According to the lecture, which one cannot be defined as a “conditionally essential amino acid” in mammals?
a)
(A). Proline
b)
(B). Tyrosine
c)
(C). Arginine
d)
(D). Histidine
e)
(E). Glutamine
44.
46. Cysteine can be made from _ in mammals.
a)
(A). pyruvate & Ser
b)
(B). pyruvate & Met
c)
(C). Met & Ser
d)
(D). a-ketoglutarate & Ala
e)
(E). Ala & Ser
45.
47. A number of compounds are synthesized from amino acids via decarboxylation. The enzymes catalyzing these steps usually use _ as a cofactor.
a)
(A). biotin
b)
(B). pyridoxal phosphate
c)
(C). vitamin B12
d)
(D). tetrahyrofolate
e)
(E). thiamine pyrophosphate
46.
48. Melatonin can be derived from?
a)
(A). Asparagine
b)
(B). Proline
c)
(C). Glycine
d)
(D). Methionine
e)
(E). Tryptophan
47.
49. The rational for treating neonatal jaundice with UV (phototherapy) is to
a)
(A). induce UDP-glucuronosyl transferase
b)
(B). promote bilirubin diglucuronide secretion
c)
(C). promote bilirubin degration
d)
(D). inhibit heme degradation
e)
(E). promote heme biosynthesis
48.
50. Glycine involves in the biosynthesis of following substances in human except
a)
(A). glutathione
b)
(B). serine
c)
(C). heme
d)
(D). pyrimidine base ring
e)
(E). phosphocreatine
100 %
