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WorksheetsMEDICINE USE IN PREGNANCY
Total questions: 20
Worksheet time: 7mins
Drugs can affect fetus at three stages:
Stages of fertilization and implantation
Stages of organogenesis
Stages of birth
Stages of growth and development
The following statements are TRUE of the pharmacokinetics changes in pregnant woman.
Reduced acid secretion
Decreased peripheral blood flow
High circulating levels of progesterone which slows down gastric emptying thus results in faster drug absorption
Increase in gastric mucus secretion
I. High level of estrogen and progesterone causes rapid metabolism of lipid-soluble drug.
II. Pregnant women tend to have decreased plasma albumin and increase body fat.
III. Glomerular filtration of preggy woman decrease by 70%.
IV. Pregnant woman should not take retinol.
Which of the following statements are TRUE?
I, II and III
I and IV
I, II and IV
II and III
FDA Pregnancy Categories The FDA has established four categories to indicate the potential of a drug to cause birth defects if used during pregnancy.
TRUE
FALSE
I. Category B
II. All trimesters are safe
III. Not teratogenic
IV. Can pass placenta
The following are the characteristics of ____________
Metoclopramide
Ondensetron
H2 Blockers
Penicillin
I. NSAIDs may cause cleft palate, intrauterine death, growth retardation and pulmonary hypertension.
II. Aspirin may increase the risk of antepartum and postpartum haemorrhage.
III. Barbiturates may cross placenta and cause cleft palate
IV. Corticosteroid can inhibit brain growth.
Which of the above statements are TRUE?
II and III
II, III and IV
I and IV
I and III
What are the principles when prescribing drug to pregnant mommy?
Use non-drug therapy when possible
Choose drug with best safety profile
Avoid medication use in 10 weeks gestation
Avoid new drug with unclear safety status
In pregnant woman
Progesterone level increases
Glomerular filtration rate increase 70%
Renal blood flow increase 50%
Plasma albumin increases
Drugs which depend mainly on kidney for elimination, are eliminated more rapidly than in non-pregnant stage.
True
False
Drugs which depend mainly on kidney for elimination, are eliminated more rapidly than in non-pregnant stage.
Penicillin
Ampicillin
Gentamicin
Cephalosporin
Which of the following statements are TRUE?
Use of ACE inhibitor during first trimester may cause renal damage in foetus
At term, the surface are of placenta is at its maximum
Thalidomide can interfere with passage of oxygen and nutrients of the fetus
Drug transferred across placenta can undergo first pass metabolism through liver
What is the effect of tetracycline towards the infant when the drug is taken during pregnancy?
Phocomelia
Discolored and deformed tooth
Retarded bone growth
CNS defect
"Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women OR no animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women"
The above statement is categorized as __________ in FDA Pregnancy Risk Categories.
Category B
Category C
Category X
Category NA
Which of the following drugs are categorized as Category D under FDA pregnancy risk categories?
Antibiotics
Streptomycin
Metronidazole
Tetracycline
I. Cephalosporin
II. Erythromycin
III. Metronidazole
IV. Aspirin
The following drugs are under ___________
Category A
Category B
Category C
Category D
I. Not teratogenic
II. May be given in clinical dose
III. Large dose of prilocaine can cause maternal and fetal hypoxia
Barbiturates
Antibiotics
Local anesthesia
Corticosteroid
Which of the drugs may cause cleft palate on the infants?
Anxiolytic agents
NSAIDs
Barbiturates
Corticosteroid
Aspirin
Medication use in 10 weeks gestation should be avoided if possible.
True
False
"It may constrict ductus arteriosus, persistent pulmonary hypertension and increase mortality"
Corticosteroid
Aspirin
NSAIDs
Anxiolytic agent
During 1-2 years before pregnancy, ________ of folic acid should be taken daily.
2 mg
10 mg
4 mg
5 mg
