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WorksheetsESC and apoptotic pathways_SSCG 4703/SSCY 3343 FS UTM
Total questions: 14
Worksheet time: 7mins
1.What do these descriptions refer to?
*A small subpopulation within the tumor
*Possess similar properties to normal stem cells
*Overexpresses a set of stem cell genes
pluripotent stem cells
cancer stem cells
embryonic stem cells
epithelial cells
what is the role of a transcription factor?
plays vital role in cellular proliferation, cellular movement, establishment of cell polarity & in stem cell maintenance
a defined cell population derived from the inner cell mass of the cleavage-stage embryo
essential for the regulation of gene expression
differentiate into any cell lineage of the body, and their potential for indefinite self-renewal.
Identify the major role/s of embryonic stem cell signalling pathways.
plays vital role in cellular proliferation
plays vital role in cellular movement
plays vital role in stem cell maintenance
plays vital role in establishment of cell polarity
The TWO (2) components below have important functions in the_____________signaling pathway.
*SMO
*PATCH
Notch
GPCR
Hedgehog
WNT
The______ and ______ are known as the genetic & epigenetic gatekeepers respectively in the Wnt-Beta Catenin signaling pathway
SFRP
SMO
SFRP
APC complex
PTCH
APC complex
APC complex
SFRP
The____________component in the Notch signalling pathway can induce proliferation and angiogenesis under abnormal condition.
CoRs
γ -secretase
MAML
CSL
Which of these are important components in the Notch signalling pathway?
I) PUMA IV) CSL
II) NICD V) MAML
III) Jag-1 VI) Destruction complex
II, III, IV and V
I, II, III, IV and V
All the above
I and VI
What happens here (3rd step)???
nuclear collapse
lysis of apoptotic bodies
chromatin condensation
continued blebbing
Highlight the main difference between both the apoptotic pathways
Extrinsic pathway: cytochrome C, Caspase 9
Intrinsic pathway: cytochrome C, Caspase 9
Intrinsic pathway: death receptors, Caspase 8
Extrinsic pathway: death receptors, Caspase 8
In healthy matured cells, the WNT signaling pathway is turned off. What is/are responsible in keeping the pathway turned off?
β-TrCP
SFRP
β-catenin
mutated APC complex
Which of these are anti-apoptotic?
I) Bax II) Bcl-xL III) Bak IV) Bcl-2 V) PUMA
I and II
II and IV
I and III
II, IV and V
Which of this/these is/are related to an apoptosome?
Cytochrome C
APaF1
Procaspase-8
Procaspase-9
What happens during the Type IIIa Hedgehog signaling pathway?
HH ligand excretion by stromal cells
HH ligand excretion by cancer cells
HH signaling in cancer cells
HH signaling in stromal cells
DNA damage is detected by _____ and activates_____.
Chk 2
NOXA
Chk 1/2
p53
p53
PUMA
Death receptor
p53
