WorksheetsChapter 186-187
Total questions: 20
Worksheet time: 15mins
Contraindications and precautions of penicillin therapy EXCEPT
Known hypersensitivity to penicillin
increased penicillin levels with probenecid and disulfiram
decreased effect of methotrexate and warfarin
use with caution in patients with renal disease
Recommended first line therapy for Pseudomonas aeruginosa
doxycycline
ciprofloxacin
azithromycin
clindamycin
Recommended first-line therapy for Bacillus anthracis
ciprofloxacin
penicillin
streptomycin
tigecycline
This drug is a second generation cephalosporin and has activity against gram positive bacilli:
Cephradrine
Cefotaxime
Cefaclor
Cephalexin
Pregnancy category of tetracyclines
A
B
C
D
After exposure to a tick, a patient develops a rickettsial infection, requiring a tetracycline-class antibiotic. A review of systems reveals that he has a history of chronic renal insufficiency. Which is the only tetracycline listed below that can be used safely in patients with renal failure?
Doxycycline
Minocycline
Tetracycline
Demeclocycline
Which of the following medications is most likely to result in increased carbamazepine levels?
Minocycline
Rifampin
Erythromycin
Dapsone
This group of antibiotics inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit and blocking transfer RNA binding to the mRNA-ribosone complex
Fluroquinolones
Tetracyclines
Cephalosporins
Lincosamides
This antibiotic inhibits bacterial cell wall peptidoglycan synthesis
tigecyclin
linezolid
quinipristin
vancomycin
Which of the following inhibits bacterial cell wall synthesis by complexing with the carrier protein C55-prenol pyrophosphatase.
Bacitracin
Polymyxin
Neomycin
Terramycin
This topical antibiotic reversibly binds to isoleucyl-transfer RNA synthetase therby inhibiting protein synthesis
Bacitracin
Mupirocin
Retapamulin
Polymyxin B
What is the mechanism of action of silver sulfadiazine
Interrups elongation of factor G thereby inhibiting protein synthesis
Inhibits peptidyl transferase via 50S bacterial ribosomes at protein L3
Targets bacterial cell wall and membrane integrity
Binds to bacterial 50S ribosomal subunit
Antibacterial coverage of retapamulin
MRSA
Pseudomonas aeruginosa
Streptococcus pyogenes
Propionibacterium acnes
Pregnancy category of topical clindamycin
A
B
C
D
This topical antibiotic inhibits bacterial protein synthesis translocation by interrupting elongation factor G
Neomycin
Polymyxin B
Bacitracin
Fusidic acid
Which medication increases blood levels of dapsone
Rifampicin
Probenecid
Cimetidine
Clindamycin
Which of the following statements regarding dapsone is true?
They exert their anti-inflammatory actions by stimulating the myeloperoxidase activity of polymorphonuclear leukocytes
Dapsone hypersenstivity syndrome is characterized by lymphocytosis
Sulfapyridine has a similar but often more severe side effect profile than dapsone
Concomittant administration of cimetidine has been shown to decrease the risk of methemoglobinemia
Which medication blocks N-hydroxylation of dapsone
Rifampicin
Omeprazole
Trimethoprim
Penicillin
Life-threatening side effect of dapsone are the following except
Dapsone hypersensitivity syndrome
Erythema multiforme
agranulocytosis
hemolysis
Dapsone is used for a patient with dermatitis herpetiformis. Dapsone induces anti-inflammatory effects by primarily inhibiting what type of cell?
T cell lymphocyte
Macrophage
Polymorphonuclear leukocyte
Langerhans cell
