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Chapter 186-187

Total questions: 20

Worksheet time: 15mins

Name
Class
Date
1.

Contraindications and precautions of penicillin therapy EXCEPT

a)

Known hypersensitivity to penicillin

b)

increased penicillin levels with probenecid and disulfiram

c)

decreased effect of methotrexate and warfarin

d)

use with caution in patients with renal disease

2.

Recommended first line therapy for Pseudomonas aeruginosa

a)

doxycycline

b)

ciprofloxacin

c)

azithromycin

d)

clindamycin

3.

Recommended first-line therapy for Bacillus anthracis

a)

ciprofloxacin

b)

penicillin

c)

streptomycin

d)

tigecycline

4.

This drug is a second generation cephalosporin and has activity against gram positive bacilli:

a)

Cephradrine

b)

Cefotaxime

c)

Cefaclor

d)

Cephalexin

5.

Pregnancy category of tetracyclines

a)

A

b)

B

c)

C

d)

D

6.

After exposure to a tick, a patient develops a rickettsial infection, requiring a tetracycline-class antibiotic. A review of systems reveals that he has a history of chronic renal insufficiency. Which is the only tetracycline listed below that can be used safely in patients with renal failure?

a)

Doxycycline

b)

Minocycline

c)

Tetracycline

d)

Demeclocycline

7.

Which of the following medications is most likely to result in increased carbamazepine levels?

a)

Minocycline

b)

Rifampin

c)

Erythromycin

d)

Dapsone

8.

This group of antibiotics inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit and blocking transfer RNA binding to the mRNA-ribosone complex

a)

Fluroquinolones

b)

Tetracyclines

c)

Cephalosporins

d)

Lincosamides

9.

This antibiotic inhibits bacterial cell wall peptidoglycan synthesis

a)

tigecyclin

b)

linezolid

c)

quinipristin

d)

vancomycin

10.

Which of the following inhibits bacterial cell wall synthesis by complexing with the carrier protein C55-prenol pyrophosphatase.

a)

Bacitracin

b)

Polymyxin

c)

Neomycin

d)

Terramycin

11.

This topical antibiotic reversibly binds to isoleucyl-transfer RNA synthetase therby inhibiting protein synthesis

a)

Bacitracin

b)

Mupirocin

c)

Retapamulin

d)

Polymyxin B

12.

What is the mechanism of action of silver sulfadiazine

a)

Interrups elongation of factor G thereby inhibiting protein synthesis

b)

Inhibits peptidyl transferase via 50S bacterial ribosomes at protein L3

c)

Targets bacterial cell wall and membrane integrity

d)

Binds to bacterial 50S ribosomal subunit

13.

Antibacterial coverage of retapamulin

a)

MRSA

b)

Pseudomonas aeruginosa

c)

Streptococcus pyogenes

d)

Propionibacterium acnes

14.

Pregnancy category of topical clindamycin

a)

A

b)

B

c)

C

d)

D

15.

This topical antibiotic inhibits bacterial protein synthesis translocation by interrupting elongation factor G

a)

Neomycin

b)

Polymyxin B

c)

Bacitracin

d)

Fusidic acid

16.

Which medication increases blood levels of dapsone

a)

Rifampicin

b)

Probenecid

c)

Cimetidine

d)

Clindamycin

17.

Which of the following statements regarding dapsone is true?

a)

They exert their anti-inflammatory actions by stimulating the myeloperoxidase activity of polymorphonuclear leukocytes

b)

Dapsone hypersenstivity syndrome is characterized by lymphocytosis

c)

Sulfapyridine has a similar but often more severe side effect profile than dapsone

d)

Concomittant administration of cimetidine has been shown to decrease the risk of methemoglobinemia

18.

Which medication blocks N-hydroxylation of dapsone

a)

Rifampicin

b)

Omeprazole

c)

Trimethoprim

d)

Penicillin

19.

Life-threatening side effect of dapsone are the following except

a)

Dapsone hypersensitivity syndrome

b)

Erythema multiforme

c)

agranulocytosis

d)

hemolysis

20.

Dapsone is used for a patient with dermatitis herpetiformis. Dapsone induces anti-inflammatory effects by primarily inhibiting what type of cell?

a)

T cell lymphocyte

b)

Macrophage

c)

Polymorphonuclear leukocyte

d)

Langerhans cell