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WorksheetsAdrenergic Agonists
Total questions: 36
Worksheet time: 18mins
Which of the following is correct regarding adrenergic
neu rotransm ission
Norepinephrine is the major neurotransmitter
released from sympathetic nerve terminals
Norepinephrine is mainly released from the adrenal
glands.
Tricyclic antidepressants and cocaine prevent the
release of norepinephrine from the nerve terminals.
Monoamine oxidase (MAO) converts dopamine to
norepinephrine in the nerve terminal.
Which of the following adrenergic drugs is used in the
treatment of overactive bladder?
Epinephrine
Dobutamine
Phenylephrine
Mirabegron
Which of the following classes of adrenergic agents has
utility in the management of hypertension?
a1 Agonist
a2
B1
B3
Which of the following is correct regarding responses
mediated by adrenergic receptors?
Stimulation of a1 receptors increases blood pressure
Stimulation of sympathetic presynaptic a2 receptors
increases norepinephrine release.
Stimulation of B2 receptors increases heart rate
(tachycardia).
Stimulation of B2 receptors causes bronchoconstriction
An asthma patient was given a nonselective p agonist to
relieve bronchoconstriction. Which adverse effect would
you expect in this patient
Bradycardia
Tachycardia
Hypotension (reduction in blood pressure)
Worsening bronchoconstriction
A 22-year-old male is brought to the emergency room
with suspected cocaine overdose. Which of the following
symptoms is most likely in this patient?
Hypertension
Bronchoconstriction
Bradycardia
Miosis (constriction of pupil)
12-year-old boy with a peanut allergy is brought to the
emergency room after accidental consumption of peanuts.
He is in anaphylactic shock. Which of the following
drugs is most appropriate to treat this patient?
Norepinephrine
Phenylephrine
Dobutamine
Epinephrine
An elderly patient is brought to the emergency room
with a blood pressure of 76/60 mm Hg, tachycardia, and
low cardiac output. He is diagnosed with acute heart
failure. Which of the following drugs is most appropriate
to improve his cardiac function?
Epinephrine
Fenoldopam
Dobutamine
Isoproterenol
Which of the following adrenergic agonists is commonly
present in nasal sprays available over-the-counter
(OTC) to treat nasal congestion?
Clonidine
Albuterol
Oxymetazoline
Formoterol
A patient who has hypertension and mild asthma attacks
bought a herbal remedy for asthma online. He does not
take any prescription medications for asthma, but takes
a ~,-selective blocker for hypertension. The herbal remedy
relieves the asthma attacks, but his blood pressure
seems to increase despite the ~-blocker therapy. Which
of the following drugs is most likely present in the herbal
remedy?
Phenylephrine
Norepinephrine
Ephedrine
Salmeterol
Which of the following drugs is a nonselective alfa receptor antagonist?
Prazosin
Phentolamine
Metoprolol
Reserpine
Sympathetic stimulation is mediated by
Release of norepinephrine from nerve terminals
Activation of adrenoreceptors on postsynaptic sites
Release of epinephrine from the adrenal medulla
All of the above
Characteristics of epinephrine include all of the following EXCEPT
It is synthesized into the adrenal medulla
It is synthesized into the nerve ending
It is transported in the blood to target tissues
It directly interacts with and activates adrenoreceptors
Which of the following sympathomimetics acts indirectly
Epinephrine
Norepinephrine
Ephedrine
Methoxamine
Indirect action includes all of the following properties EXCEPT:
Displacement of stored catecholamines from the adrenergic nerve ending
Inhibition of reuptake of catecholamines already released
Interaction with adrenoreceptors
Inhibition of the release of endogenous catecholamines from peripheral adrenergic neurons
Catecholamine includes following EXCEPT
Ephedrine
Epinephrine
Isoprenaline
Norepinephrine
Epinephrine decreases intracellular camp levels by acting on
alpha 1 receptor
alpha2 receptor
beta1 receptor
beta2 receptor
Which of the following statements is not correct
ALFA receptors increase arterial resistence, whereas beta2 receptor promote smooth muscle relaxation
The skin and splanchic vessels have predominantly alfa receptors
Vessels in a skeletal muscle may constrict or dilate depending on whether alfa or beta2 receptors are activate
Skeletal muscle vessels have predominantly alfa receptors and constrict in the presence of epinephrine and
norepinephrine
Direct effects on the heart are determined largely by:
Alfa1 receptor
Alfa2 receptor
Beta1 receptor
Beta2 receptor
Which of the following effects is related to direct beta1-adrenoreceptor stimulation?
Bronchodilation
Vasodilatation
Tachycardia
Bradycardia
Distribution of alfa adrenoreceptor subtypes is associated with all of the following tissues except those of:
Heart
Blood vessels
Prostate
Pupillary dilator muscle
Beta adrenoreceptor subtypes is contained in all of the following tissues EXCEPT:
Bronchial muscles
Heart
Pupillary dilator muscle
Fat cells
In which of the following tissues both alfa and beta1 adrenergic stimulation produces the same effect?
Blood vessels
Intestine
Uterus
Bronchial muscles
The effects of sympathomimetics on blood pressure are associated with their effects on
The heart
The peripheral resistance
The venous return
All of the above
A relatively pure alfa agonist causes all of the following effects EXCEPT:
Increase peripheral arterial resistance
Increase venous return
Has no effect on blood vessels
Reflex bradycardia
A nonselective beta receptor agonist causes all of the following effects EXCEPT:
a) Increase cardiac output
b) Increase peripheral arterial resistance
c) Decrease peripheral arterial resistance
d) Decrease the mean pressure
Increase cardiac output
Increase peripheral arterial resistance
Decrease peripheral arterial resistance
Decrease the mean pressure
Which of the following statement is not correct
Αlfa agonists cause miosis
Αlfa agonists cause mydriasis
Beta antagonists decrease the production of aqueous humor
Αlfa agonists increase the outflow of aqueous humor from the eye
A bronchial smooth muscle contains
Αlfa1 receptor
Αlfa2 receptor
Beta 1 receptor
Beta 2 receptor
All of the following agents are beta receptor agonists EXCEPT
Epinephrine
Isoprotereno
Methoxamine
Dobutamine
Which of the following drugs causes bronchodilation without significant cardiac stimulation
Isoprenaline
Terbutaline
Xylometazoline
Methoxamine
Αlfa-receptor stimulation includes all of the following effects EXCEPT:
Relaxation of gastrointestinal smooth muscle
Contraction of bladder base, uterus and prostate
Stimulation of insulin secretion
Stimulation of platelet aggregation
Beta1 receptor stimulation includes all of the following effects EXCEPT:
Increase in contractility
Bronchodilation
Tachycardia
Increase in conduction velocity in the atrioventricular node
Beta2 receptor stimulation includes all of the following effects EXCEPT:
Stimulation of renin secretion
Fall of potassium concentration in plasma
Relaxation of bladder, uterus
Tachycardia
Hyperglycemia induced by epinephrine is due to:
Gluconeogenesis (beta2)
Inhibition of insulin secretion (alfa)
Stimulation of glycogenolysis (beta2)
All of the above
Which of the following effects is associated with beta3-receptor stimulation?
a) Lipolysis
b) Decrease in platelet aggregation
c) Bronchodilation
d) Tachycardia
Lipolysis
Decrease in platelet aggregation
Bronchodilation
Tachycardia
Which of the following statements is not correct
Epinephrine acts on both alfa- and beta-receptors
Norepinephrine has a predominantly beta action
Methoxamine has a predominantly alfa action
Isoprenaline has a predominantly beta action
