Which of the following are delivered by pulmonary delivery? Select all that apply

Because of the large size of protein, they cannot be used for pulmonary delivery.

In the branching of airways, the further away from the mouth, the larger the surface area.

Surface area of airways increases with the increase in the generation.

Surface area increases with the increasing distance of the airway from the glottis.

Diameter of airways decreases with the increasing generation of airway..

Surface area decreases with the increasing distance of the airway from the glottis.

What are the advantages of the pulmonary drug delivery system? Select all that apply

Pulmonary delivery usually has delayed onset of action.

What are the disadvantages of the pulmonary drug delivery system? Select all that apply

Pulmonary delivered drugs may produce local side effects due to oropharyngeal deposition.

Tidal volume is the volume of air inhaled in a single breath.

Aerosols are administered through the mouth so can reach the deeper lung.

Pulmonary delivery dosage forms are inhaled through the nose.

For pressurized metered dose inhalers (pMDIs), the momentum of aerosol particles generated depends on the device rather than the patient’s IFR.

Which of the following are TRUE about efficient deposition in Breath Holding? Select all that apply

For efficient deposition, breath holding for a period less than 5 seconds after inspiration is recommended.

Narrowing airways can increase linear velocities, enhance inertial impartation, and produce more deposition in the central airways.

Narrowing airways can decrease linear velocities, enhance inertial impartation, and produce more deposition in the central airways.

Inertial impaction is the general mechanism for deposition of particles greater than 5 microns in diameter.

Inertial deposition increases with particle velocity, diameter and density.

Inertial deposition decreases with particle velocity, diameter and density.

Inertial deposition of particles occurs in zones of highest airflow velocity.

Deposition by sedimentation mainly occurs in the small (distal) airways in the lung periphery.

Gravitation sedimentation is larger in diameter than Brownian diffusion.

Deposition by diffusion increases with the decrease in particle size, and breath-holding following inhalation.

Particles larger than 10um deposits in the upper airways.

Particles of 5-10um deposits in the tracheobronchial surface.

Particles of 0.5-5um deposits in the alveolar levels.

About 50% of 0.5 mm particles are deposited in the alveoli by diffusion and the rest are exhaled or may not deposit at all.

Particles with a diameter of 1-5um show efficient penetration into the lungs.

Dissolution in the mucus is the rate limiting step for absorption of poorly water soluble drugs.

The rate of diffusion through the mucus depends on which of the following? Select all that apply

Which of the following are the barriers to pulmonary absorption? Select all that apply

Which of the following is the first barrier encountered by particles in the pulmonary delivery?

Dissolution in the mucus is the rate limiting step for absorption of water soluble drugs.

Self-cleansing mechanism of the respiratory system?

Which of the following is a self cleansing mechanism that can eliminate fluids, microbes and particles within a few hours?

Which of the following is the major barrier for pulmonary delivery engulfed by macrophages and then eliminated via the lymphatic system or absorbed into the pulmonary circulation?

The macrophages engulfed particles will be eliminated via the lymphatic system or absorbed into the pulmonary circulation.

Aerosols depend on the functioning of the container and propellant.

Which of the following can be used as Propellant?

Which of the following can be used as Propellants? Select all that apply

Propane, butane and isobutane cannot be used as propellant.

Which of the following pressurized containers has good chemical compatibility and poor pressure resistance.

Tin plated steel is the most common used metal for aerosol containers.

Which of the following of the metal containers is usually used in small volume aerosols?

Special coatings improve the chemical compatibility in metal containers.

Which of the following containers are permeable to the vapor inside the container and there are drug-plastic interactions ?

The actuator in the valve assembly prevents leakage of the formulation when the valve is in the closed position.

Which of the following are TRUE statements about Pressurized Metered Dose Inhalers (pMDIs)? Select all that apply

If the drugs are suspended or emulsified in the propellant system , constant agitation during manufacture and use is required.

What is the unit for valve discharge rate?

Valve discharge rate of an aerosol is the amount of the drug discharged per unit of volume.

Which of the following are the proper auxiliary labels for aerosols? Select all that apply

Medicinal aerosols are labeled by the manufacturer with peel away labels that can be replaced by a pharmacist to give more information to the patient.

The pharmacists are not allowed to put any label on aerosol container because only the manufacturers can do that.

Which of the following statements are TRUE about PATIENT COUNSELING on aerosols? Select all that apply

If multiple dosing is recommended in administering a pMDI, the patient needs to wait for about 1 minute interval between actuations.

A pressurized jet air stream delivered by a compressor forced through Venturi?

Piezo-electric crystals produce high frequency sound waves in the nebulizer solution?

Which of the following nebulizers is lighter on weight and quieter on sound?

In Air-Jet Nebulizers crystallization of drug may occur.

In Ultrasonic Nebulizers CANNOT nebulize high viscosity liquids and may increase in temperature causes degradation of thermo-sensitive drugs.

Ultrasonic nebulizers CAN nebulize high viscosity liquids.

Which of the following statements are TRUE about PATIENT COUNSELING on Nebulizers? Select all that apply

Which of the following statements are TRUE about Dry Powder Inhalers? Select all that apply

Dry Powder Inhalers are more patient friendly and requires less coordination between patient breath and drug inhalation.

Which of the following are TRUE when COUNSELING A PATIENT with the use of Dry Powder Inhalers? Select all that apply

Phase 2 is more aligned to solutions.

Phase 3 is more aligned to suspension and emulsion.