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WorksheetsPharmaceutics III: Exam 1 (Dr.P)
Total questions: 23
Worksheet time: 6hrs 45mins
Which of these describes zero-order reactions?
-dC/dt=KC
The rate of reaction is independent of remaining concentration
The rate of reaction is proportional to or dependent on remaining concentration
Half-life is independent of initial concentration
Which of these best describes first-order reactions?
lnC=lnC0-Kt
Slope=-K0
Rate of reaction is independent of remaining concentration
Half-life increases with increasing initial concentration
Which of these correctly describes half-life for zero and first order reactions
Zero Order:
t1/2=0.693/K
First Order:
t1/2=0.693/K
First Order:
t1/2= C0/2K0
Zero Order:
t1/2= C0/2K0
What are the rate constants and units for zero and first order reactions?
Zero Order:
concentration/
time
First Order:
time-1
First Order:
concentration/
time
Zero Order:
time-1
Which of these represents a zero order reaction?
Which of these represents a first order reaction plotted on regular graph paper?
Which of the following expressions is the accurate depiction of the rate of degradation of hydrocortisone alcohol, P1? Ignore the graph and review the degradation pathway/equation next to the graph
-d[P1]/dt=
K2[P2] - K1 [P1]
-d[P1]/dt=
K2[P1] - K1[D]
-d[P1]/dt=
K1[D] - K2[P1]
-d[P1]/dt=
K2[P1] + K1[D]
Which of the following expression is the accurate depiction of the rate of degradation of triazolam? Ignore the graph and review the degradation pathway/equation...
Triazolam--Kf-->Hydrolysis product
Hydrolysis product--Kr--> Triazolam
-d[Triazolam]/dt=
Kr[Triazolam]-Kf[Hydrolysis Pro.]
-d[Triazolam]/dt=
Kf[Triazolam]+
Kr[Hydrolysis Pro.]
-d[Triazolam]/dt=
Kf[Triazolam]-Kr[Hydrolysis Pro.]
d[Triazolam]/dt=
Kf[Triazolam]-Kr[Hydrolysis Pro.]
For a drug degrading by zero order kinetics, concentration of the drug decreases with time in an exponential trend
True
False
The slope of a semi-log plot of concentration (mcg/mL) against time (days) of a drug following apparent first order degradation is found to be -0.0032. Calculate the degradation rate constant.
2.3*10-3day-1
3.2*10-3day-1
1.39*10-3day-1
7.37*10-3day-1
A rectilinear plot of concentration against time of a drug that is degrading by first order yields a declining straight line.
True
False
A drug is given intravenously and the blood concentration measured at 1 and 4 hours are 26 and 18 mcg/mL. What is the half life using first order kinetics? Round to the tenths place. NO UNITS
(a)
Which of the following statement(s) is/are true regarding pseudo zero-order reaction?
Rate of degradation is dependent of initial concentration which is either large or is a constant
Amount of drug degraded over the same time period will be the same
Half-life is independent of initial concentration
Rate of degradation is independent of initial concentration
The pseudo zero-order rate constant is expressed as concentration/
time
Which of the following statements is/are true regarding first-order reaction?
Amount of drug degraded at over the same time period will be the same
Proportion of drug remaining unchanged over the same time period will be the same
Half life is directly proportional to initial concentration
Half-life is inversely proportional to rate constant
The rate constant is expressed as concentration/
time
Rate of a zero order degradation reaction (dC/dt) is plotted against initial concentration. What would the trend of the resulting profile be?
Inclining straight line
A flat straight line parallel to the x-axis
Declining straight line
A declining curve
Which one of the following is NOT a characteristic of a zero-order drug decomposition reaction?
The units of the rate constant (k) are time-1
The rate of reaction is constant
The half-life of the drug decomposition is directly proportional to the initial concentration of API
The rate of reaction is independent of the concentration of any of the reactants
A 5% drug solution decomposes with a rate constant, k, of 0.05/day. Calculate the time for the drug concentration to degrade to 2.5mg/mL. Round up to the nearest whole number. NO UNITS
(a)
A drug solution decomposes with a rate constant, k, 0.0077 days-1. What is the half-life of the drug solution? Round to the nearest whole number. NO UNITS
(a)
The concentration of reactant in solution remain constant as long as there is excess solid present
True
False
Which of these is the rate equation for pseudo-zero order reactions?
lnC=lnC0-k'1t
C=C0-k'0t
C=C0-kt
lnC=lnC0-kt
Which of these is the rate equation for pseudo-first order reaction?
C=C0-k'0t
lnC=lnC0-kt
lnC=lnC0-k'1t
C=C0-kt
You must linearize the data before finding the slope and rate constant
True
False
Which of these statements best describe this reaction?
This reaction is only degrading product A
-dA/dt=
(k1+k2)[A]
dA/dt=
(k1+k2)[A]
This reaction is only synthesizing product A
