Aka Benzylpenicillin

Not to be used in general therapy to avoid possible widespread development of organisms resistant to it.

Use is restricted to the tx of infections caused by staphylococci resistant to Pen G.

It has substituents in positions ortho to the point of attachment of the aromatic ring to the carboxamide

group of penicillin

Identify the structure

What is the primary role of agents such as Tazobactam and Sulbactam in antibacterial therapy?

Methicillin is chemically named as:

Amoxicillin is:

Structure of the penicillin molecule shows it to contain a fused ring system which is the:

Identify the structure

Identify the structure

The so-called Isoxazolyl penicillins are primarily indicated for the treatment of infection caused by

what organism?

This quinine derivative appears to disrupt mitochondrial electron transport in protozoa

Used in fixed combination with artemether for uncomplicated falciparum malaria in many countries

Which is not used for chemoprophylaxis because of its potential for quinidine-like cardiotoxicity (QT prolongation) and embryotoxicity

Which of the ff. is metabolized in the food vacuole of the parasite forming toxic free radicals and is the standard of care for all chloroquine- resistant malaria

Which of the ff. may cause cinchonism

Which of the ff is a blood schizonticide

Which of the ff may cause folic acid deficiency when used in high doses?

Which of the ff is bioactivated to cycoguanil?

Which of the ff forms quinoline-quinone metabolites, which are electron-transferring redox compounds that act as cellular oxidants?

Which of the ff may cause GI distress, rash, headache, auditory dysfunction and retinal dysfunction at high doses?

Which of the ff. is used topically in the treatment of burns?

Imidazole antifungal

Agent of choice for the treatment of bacterial gastroenteritis caused by gram- negative bacilli.

Act as noncompetitive inhibitors of (1,3)-β-d-glucan synthase, enzyme complex that forms

stabilizing glucan polymers in fungal cell wall

Acts as a tight-binding noncompetitive inhibitor of enzyme inositol phosphorylceramide synthase

which is an enzyme essential for fungal sphingolipid biosynthesis

Which of the ff. Is a urinary analgesic?

Which of the ff. Is an inhibitor of squalene epoxidase?

Which of the ff. concentrates at keratin precursor cells found in nails, skin & hair w/c are

gradually exfoliated & replaced by new tissues?

Which of the ff. causes leakage of both potassium ion & cell lysis at same concentration?

Which of the ff. Provides the best distribution of the currently marketed quinolones?

Remains the standard to which the activity of most germicidal substances is compared

Which of the ff. organic dyes has been used orally as an anthelmintic for strongyloidiasis and oxyuriasis?

Which of the ff. Is added to formalin to retard polymerization of formaldehyde?

Which of the ff. Is used in the treatment of acne?

A process that kills nonsporulating microorganisms by hot water or steam at 65℃-100℃?

Refers to ethanol treated with one or more substances so that its use may be permitted for a

specialized purpose.

It has been used to sterilize temperature- sensitive medical equipment and certain pharmaceuticals

that cannot be heat sterilized in an autoclave.

Refers to application of an agent to living tissue for the purpose of preventing infection.

Which of the ff. Preservatives is used as a bacteriostatic agent in pharmaceuticals for

injection, ophthalmic use, and intranasal administration?

4-chloro-3-methylphenol

Is expressed as the mass of solute per volume (g/L) or mass of solute per mass of solvent (g/g),

or as the moles of solute per volume (mol/L).

Refers to compounds that are obtained by donating electrons to metal ion with the formation

of a ring structure.

Refers to compounds capable of forming a ring structure with a metal atom

Which of the ff. acts as antibacterial and antifungal agents by complexing with iron and copper.

Which of the ff. Is a weak base?

The ff. polar groups can be added to increase solubilty of the molecule by increasing

hydrogen bonding and the interaction with water.

Refers to the ability of a drug to dissolve in a lipid phase when an aqueous phase is also present

pKa refers to

Which of the ff. Methods increases water solubilty of drugs

It is an effective antidote for organic arsenical, Lewisite, but can also be used for treatment

of poisoning due to antimony, gold and mercury

Major site of metabolism:

Which of the following functional groups of drugs is NOT susceptible to phase I metabolic reactions: