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Modified Release Dosage Form

Total questions: 53

Worksheet time: 4hrs 25mins

Name
Class
Date
1.

Which of the following commercial product represents an example of a non-disintegrating matrix type modified release dosage form?

a)

Micro KR 10 meq

b)

Klorn-conR 10 meq

c)

K-DurR 20 meq

d)

Adalat CCR

e)

Glucotrol XLR

2.

Which of the following factors will influence the drug release from a coated slow-release bead type modified release dosage form? Select all that apply.

a)

Thickness of the coat

b)

Permeability of the polymer

c)

Osmotic pressure of the dissolution fluid

d)

True density of a drug

e)

Solubility of a drug inside the bed

3.

Which of the following commercially available product uses the coated bead technique to control the release of the drug?

a)

Welbutrin XL

b)

K-Dur

c)

Slow-K

d)

Ambien CR

e)

Micro K

4.

Which of the following is the unit for the rate constant associated with the slow first order release of a drug from a modified release dosage form?

a)

hr1/2

b)

mg/hr

c)

hr.mg-1

d)

mg.ml-1hr-1

e)

hr-1

5.

Which of the following unit applies to a rate constant when the drug release data, from a modified release form, is fitted to the square root or cubic equation?

  

a)

mg.hr-1

b)

hr1/2

c)

hr-1

d)

hr-1/2

6.

Which of the following unit applies to a rate constant when the drug release data, from a modified release dosage form, is fitted to the zero order process?

   

a)

Hr1/2

b)

Mg.hr-1

c)

Hr-1

d)

Mg.hr

7.

Which of the following is/are reasons to develop a drug formulation in a modified release dosage form?

   

a)

Creating a pharmaceutical alternative

b)

Altering the pharmacological activity pf a drug

c)

Altering the duration of action of a drug

d)

Developing a less expensive dosage form

8.

Which of the following therapeutic agent is/are available in modified release forms?

    

a)

Potassium chloride

b)

Lorazepam

c)

Amoxicillin

d)

Lisinopril HCL

9.

Which of the following properties will influence the drug release from a modified release dosage form?

   

a)

Equilibrium solubility

b)

Diffusion coefficient

c)

Angle of repose

d)

Contact angle

10.

Which of the following routes of administration can be used to administer a drug via modified release dosage form?

   

a)

Oral

b)

Ocular

c)

Oral and topical only

d)

Topical

11.

Which of the following constitute the major advantages of administering a drug via modified release dosage form?

    

a)

Improved patient compliance

b)

Better bioavailability

c)

Increase frequency of administration

d)

Reduced frequency of administration

12.

Which of the following property of a therapeutics agent makes it a poor candidate for modified release dosage form?

a)

Rapid drug absorption

b)

Long elimination half life

c)

Broad therapeutic range

d)

Short elimination half-life

13.

Which of the following are considered as modified release dosage form?

     

a)

Porous matrix type tablet

b)

Liquid with ion exchange resin

c)

Sugar coated tablet

14.

Which of the following therapeutic agent is available as an enteric coated type modified release dosage form?

     

a)

Aspirin

b)

Nifedipine

c)

Potassium Chloride

d)

Acetaminophen

15.

Which of the following therapeutic agent is available as a coated bead type modified release dosage form?

   

a)

Potassium chloride

b)

Aspirin

c)

Nifedipine

d)

Acetaminophen

16.

Which of the following inactive ingredient is added to the drug solution prior to its application on to the core spherical beads in a certain type of modified release dosage form?

    

a)

Fixing agent

b)

Diluent

c)

Preservative

d)

Coloring agent

17.

Which of the following excipient is likely to present in a coating solution of a certain type of modified release dosage form?

a)

Coloring agent

b)

Antioxidant

c)

Fixing agent

d)

Preservative

18.

Which of the following commercial product belong to the class of modified release dosage form that uses coated beads?

a)

K-dur

b)

Nexium

c)

Klor-con

d)

Ambien

19.

Which of the following physical chemical property is utilized in developing G.I.T.S. type modified release dosage form?

a)

Diffusion

b)

Dissolution

c)

Osmotic pressure

d)

Solution pH

20.

Which of the following commercial product belong to the G.I.T.S. type modified release dosage form?

a)

Glucotrol XL

b)

Cardizem SR

c)

Micro-K

d)

Wellbutrin SR

21.

Which of the following polymers are frequently used in various types of modified release dosage forms?   

a)

Sodium Lauryl sulfate

b)

Eudragit S

c)

Eudragit R

d)

Ethyl cellulose

e)

Methyl cellulose

22.

Which of the following fats and waxes are frequently used in various types of modified release dosage forms?  

a)

Peg 800

b)

Eudragit E

c)

Eudragit L

d)

Hydrogenated castor oil

e)

White wax

23.

  Which of the following may be use as excipients to control the drug release from various modified release dosage forms?

 

a)

  Startch

b)

Eudragit R ion exchange resins

c)

  Methylcellulose

d)

Carnauba wax

24.

Which of the following are the examples of  the inert ‘ghost’ matrix (tablet with no drug inside) is removed from the body intact into feces?

 

a)

Nexium

b)

Fero-GradumetR

c)

Theo-Dur

d)

K-Dur

e)

Slow KR

25.

Which of the following equations may be commonly employed to describe drug release from modified release dosage forms?

a)

Noyes-Whitney equation

b)

Yang’s equation

c)

Fick’s equation

d)

First order equation

e)

Higuchi equation

26.

Which of the following according to Higuchi equation will influence the drug release from modified release dosage forms?

     

a)

Specific surface

b)

Hydrophobicity

c)

Porosity

d)

Amount of drug present per unit area

e)

True density

27.

Which of the following according to the Higuchi equation will yield a straight line with a positive slope?

    

a)

Amount of drugs remaining to be release against square root of time (RL paper)

b)

Cumulative amount of drug release against square root of time (SL paper)

c)

Cumulative amount of drug release against square of time (SL paper)

d)

Cumulative amount of drug release against time (RL paper)

e)

Cumulative amount of drug release against square root of time (RL paper)

28.

Which of the following equation can be used to describe a drug release from a cylindrical non disintegrating matrix type modified release dosage form with all surface exposed to the dissolution fluid?

     

a)

Zero order equation

b)

Higuchi square root equation

c)

First order equation

d)

Cubic equation

29.

Which of the following is true about the various types of coated tablets?

    

a)

Most of the available coated tablets are enteric coated

b)

Most of the available coated tablets are film coated

c)

Most of the available coated tablets are sugar coated

30.

Which of the following is true about the enteric-coated tablets?

    

a)

The coating will dissolve only above pH of 10.0

b)

The coating will dissolve only at pH of 4.0

c)

The coating will dissolve only in alkaline condition

d)

The coating will dissolve only in acidic condition

31.

Which of the following will control the drug release from beads as a modified release dosage form?

    

a)

Thickness of the coating layer

b)

Thickness of the drug layer

c)

Concentration of a fixing agent

d)

Concentration of a drug

32.

Which of the following will contribute to slower drug release from a non-disintegrating matrix type modified release dosage form?

    

a)

High tortuosity

b)

Low tortuosity

c)

High true density of a drug

d)

High equilibrium solubility of a drug

e)

High porosity

33.

Which of the following parameters are dimensionless?

    

a)

Porosity

b)

Tortuosity

c)

Specific surface

d)

Surface area

e)

Partition Coefficient

34.

Which of the following acrylic resins are frequently used in various types of modified release dosage forms?

   

a)

Carnauba wax

b)

Eudragit LR

c)

Eudragit SR

d)

Eudragit ER

35.

Which of the following biodegradable polymers are frequently used in various types of modified release dosage forms?

   

a)

Ethyl Cellulose

b)

Glycolic/lactic acid copolymers

c)

Poly-DL lactic acid

d)

Polyglycolic acid

36.

All tablets must pass for disintegration except Chewable tablets and Extended/Modified release tablets?

a)

True

b)

False

37.

The higher the compressional forces, the higher is the matrix tortuosity

a)

True

b)

False

38.

Modified dosage form has a longer duration of action.

a)

True

b)

False

39.

Which of the following formulation factor play important role in influencing the release of drug?

a)

Higher drug

b)

Surface area

c)

Tortuosity

d)

Porosity

40.

Which of the following is/are true about the property tortuosity?

     

a)

Its lowest value is one

b)

It is inversely proportional to the compressional force?

c)

It influences drug release from a certain type of modified release dosage form

41.

Which of the following commercially available product(s) are prepared by employing the principle of osmotic pressure difference between the solution inside and outside the dosage form?

    

a)

Omeprazole

b)

Wellbutrin^R XL

c)

Concerta^R

42.

Which of the following property of a drug is considered ideal for its development into a modified release dosage form?

    

a)

High aqueous solubility

b)

Long elimination half-life

c)

Short elimination half-life

d)

High dose

43.

Tortuosity is one of the factors that influence the release of a drug from a non-disintegrating matrix type modified release dosage form. In general, the greater the tortuosity, the faster is the drug release from the dosage form.

   

a)

True

b)

False

44.

Which of the following will influence the drug release from the porous non-disintegrating matrix release dosage form?

   

a)

Thickness of the coating material

b)

Equilibrium solubility of the matrix

c)

Tortuosity of the matrix

d)

True density of the powder

45.

Which of the following is formulated as slow release beads? (Select all that apply)

      

a)

Nexium

b)

Adalat CC

c)

MicroK 

d)

K-Dur

46.

Which of the following is considered as an advantage of a modified or controlled release dosage form?

 

a)

Increased drug accumulation

b)

Longer duration of action

c)

Increased frequency of drug administration

d)

Reduced local irritation of all drugs

47.

Non-disintegrating matrix type modified release tablets are prepared by compressing the therapeutics agent, excipient, and polymers. In general, the higher the compressional forces employed to prepare the greater is the porosity and tortuosity of the matrix.

a)

True

b)

False

48.

Which of the following products, though they contain an identical amount of an identical

therapeutic agent, are not interchangeable?

     

a)

Diltiazem

b)

Zantac

c)

K-dur

d)

Klor-con

49.

Which of the following therapeutic agent is available in a modified release dosage form described as OROS?   

a)

Glipizide

b)

Procainamide

c)

Potassium chloride

d)

Methylphenidate

50.

Which of the following products use the principle of osmotic pressure difference in controlling the drug release (Select all that apply).

a)

Ambien CRRAmbien\ CR^R  

b)

ConcertaRConcerta^R  

c)

Theo−DurRTheo-Dur^R  

d)

Ditropan XLRDitropan\ XL^R  

e)

LipitorRLipitor^R  

51.

Which of the following apply to porosity and tortuosity; two parameters that apply an important role in influencing the drug release from a certain type of a modified release dosage form.

a)

Each parameter influences the drug release from a non-disintegrating matrix type modified release dosage form.

b)

Each parameter is directly proportional to the compressional forces.

c)

Each parameter influences the drug release from coated bead type modified release form.

d)

The lowest value for each parameter is zero.

52.

There are some striking differences between zero and first order processes; unit for the rate constant and the integrated equation are two of them.

a)

True

b)

False

53.

Which of the following property of a drug is ideal to prepare a modified release dosage form?

a)

Narrow therapeutic range

b)

Long elimination half-life

c)

Highly insoluble drug

d)

Short elimination half-life

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