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Immune 1

Total questions: 90

Worksheet time: 45mins

Name
Class
Date
1.

Among the 5 lg isotypes, which one has more heavy chain subtypes than the

others?

a)

IgA

b)

IgD

c)

IgG

d)

IgM

e)

IgE

2.

Effector cells secret....... That can kill virus infected cells.

a)

Granzyme

b)

Defensin

c)

Ubiquitin

d)

Exonuclease

e)

 Cathelicidin

3.

The IL-1 cytokine plays an important role in which of the following?

a)

 Direct killing of infected cell

b)

Phagocytosis

c)

Clonal expansion

d)

Inflammation

e)

Antiviral defense

4.

Which region of secreted lg can perform effector function?

a)

FAB region

b)

Variable domain

c)

Antigen binding site

d)

Fc region

e)

Hinge protein

5.

B cells originate from bone marrow, but where do they get maturation?

a)

Mucosal tissue

b)

Thymus

c)

Spleen

d)

Lymph nodes

e)

Bone marrow

6.

Which of the following is not a professional APC?

a)

B cell

b)

DC

c)

Macrophage

d)

FDC

e)

 Mast cell

7.

Some receptors are expressed at a late stage, once the infection has gone or almost gone. What is their role (for example, CTLA-4 and PD-1)?

a)

Increase of T cell activation

b)

Inhibition of T cell activation

c)

Control of the cell cycle

d)

Increase of cytotoxic granule

e)

Induction of inflammation

8.

From which of the following stem cell types do all leukocytes originate?

a)

Common myeloid progenitor

b)

Mesenchymal stem cell

c)

Common lymphoid progenitor

d)

Hematopoietic stem cells

e)

 Mast cell

9.

APC cells are called professional APC cells because they perform which of the following functions?

a)

Present antigen to CD8+ T cell

b)

Perform phagocytosis

c)

Digest any substances

d)

Opsonize microbes

e)

Present antigen to CD4+ T cells

10.

T cell activation can be completely performed by the co-stimulation receptor called how?

a)

CD28 

b)

 CD40

c)

TCR

d)

 IL-2R

e)

Lectin receptor

11.

Why are red blood cells categorized as non-nucleated cells?

a)

Have no cell nucleus

b)

Not raise to other leukocytes

c)

Look red color

d)

Have no effector function

e)

Not display microbial antigen

12.

Which of the following major innate immune receptors plays a role in signal transduction upon binding to extracellular PAMPs?

a)

C-type lectin receptor

b)

Toll-like receptors

c)

NOD-like receptors

d)

RIG-like receptors

e)

Cytosolic DNA sensor

13.

The fusion of immunized B cells with a myeloma line generate which cells that can produce monoclonal abs?

a)

Hybridoma cells

b)

Activated B cells

c)

Myeloid progenitor cells

d)

HSC

e)

Plasma cells

14.

What is the role of C3a fragments during complement system activation?

a)

Enhancement of apoptosis

b)

Induction of inflammation

c)

Direct killing of microbes

d)

Degranulation

e)

Enhancement of phagocytosis

15.

Why CD8+ T cell numbers expand more than CD4+ T cell numbers during an infection?

a)

To provide more cytokine

b)

To activate APCs

c)

To kill extracellular bacteria

d)

To induce inflammation

e)

To kill infected cells

16.

Which of the following cytokines enhances the phagocytic activity of macrophages?

a)

IFN-y

b)

 IL-1

c)

TNF-a

d)

TGF-ß

e)

IL-4

17.

What is the role of IL-2 in T cell development and activation?

a)

VDJ recombination

b)

 Adhesion

c)

 Proliferation & survival

d)

Migration to infected site

e)

T cell maturation

18.

Which of the following enzymes play a role in somatic recombination?

a)

Protease

b)

VDJ recombinase

c)

Helicase

d)

Ubiquitin

e)

Caspase I

19.

Innate cells provide a frontline defense against infections. Which of the following is not considered an innate immune cell?

a)

NK cell

b)

Neutrophil

c)

Regulatory Th cell

d)

 Basophil

e)

Intraepithelial T cell

20.

Which of the following is the structural composition of MC class Il?

a)

a chain + B chain

b)

a chain+ B2m protein

c)

Heavy chain + light chain

d)

Iga + Igß

e)

CD3 + Z protein

21.

Which peripheral lymphoid lymphoid tissue has mostly lymphocytes?

a)

 Spleen

b)

 Lymph nodes

c)

 Pancreas

d)

Skin

e)

Liver

22.

All nucleated cells can present antigen to CD8+ cells because they express which of the following?

a)

MHC-class II

b)

C-type lectin receptor

c)

MHC-class I

d)

C3 receptor

e)

IFN receptor

23.

Among the following lg isotypes, which one remains on the cell surface of activated B cells?

a)

 IgA1

b)

IgA2

c)

IgE

d)

IgG

e)

IgD

24.

Which of the following represents a passive immunization?

a)

Serum antibody transfer

b)

Infection with virus

c)

Vaccinate with kill virus

d)

Infect with bacteria

e)

Vaccinate with weak bacteria

25.

Which of the following are the precursor cells of monocytes?

a)

Platelet

b)

Nucleated cell

c)

Hematopoietic stem cell

d)

Common lymphoid progenitor

e)

 Common myeloid progenitor

26.

Dendritic cells migrate to the T cell zone but not to the B cell zone in lymph nodes because they express which of the following?

a)

IL-2R

b)

IFN receptor

c)

 CD28

d)

CCR7

e)

CD40

27.

What is the antigen recognition receptor of B cells?

a)

IL-2R

b)

TLRs

c)

CD28

d)

BCR

e)

NOD-like receptor

28.

 What is the ligand for the CD28 receptor expressed on lymphocytes?

a)

CD40

b)

 IL-1

c)

B7-1

d)

IFN-a

e)

PD-L1

29.

Which protein complex degrades ubiquitinated proteins?

a)

Keratin

b)

Proteasome

c)

Invariant chain

d)

Lysosomal protease

e)

Phagocyte oxidase

30.

 How do NK cells in an innate immune response kill virus-infected cells?

a)

By phagocytosis

b)

By cytotoxic granules

c)

By lysosomal enzymes

d)

By ubiquitination

e)

By activation of MP

31.

Among these receptor proteins, which one does not have a signaling domain?

a)

CD3

b)

Zeta protein

c)

CD8

d)

CD4

e)

TCR

32.

 If the host gets infected with fungi, which T cells subset will CD4+T cells differentiate to?

a)

Th-1 cells

b)

Th-2 cells

c)

Th-17 cells

d)

Tfh cells

e)

Regulatory T cells

33.

 What is the major cytokine produced by Th-17 cells?

a)

 IL-4

b)

 IL-13

c)

IL-22

d)

IFN-a

e)

TGF-B

34.

 Which cytokine is required for CD4+ T cells to differentiate into Th-1 cells?

a)

IL-1

b)

IL-2

c)

IL-3

d)

IFN-a

e)

IL-12

35.

Innate cells provide a frontline defense against infections. Which of the following is NOT considered an immune cell? 

a)

 NK cell

b)

Neutrophil

c)

Regulatory Th cell

d)

Basophil

e)

Intraepithelial T cell

36.

Which of the following cytokines enhances the phagocytic activity of macrophages?

a)

IFN-Y

b)

IFN-Y

c)

TNF-a

d)

TNF-a

e)

IL-4

37.

Which T lymphocytes that do NOT differentiate from CD4+ T cells?

a)

Th-17 cells

b)

Regulatory T

c)

Th-2 cells

d)

Cytotoxic T cells

e)

Tfh cells

38.

The role of alternative activated macrophage (M2) is

a)

Anti-inflammation

b)

 Phagocytosis

c)

Degranulation

d)

M1 activation

e)

 Ingestion of microbe

39.

Among these cytokines, which one plays a critical role in the activation of Eosinophil in mediated-killing of parasites?

a)

IFN-y

b)

IL-5

c)

IL-10

d)

IL-17

e)

IL-1

40.

To fully activate naive B cells, it is required the activation of.

a)

CD40

b)

CD28

c)

IL-2R

d)

 Lectin receptor

e)

IFN receptor

41.

1.What are the structural complex of membrane Ig?

a)

BCR + Iga + Igß

b)

TCR + CD3 + c

c)

a chain + B2m

d)

a chain + ß chain

e)

TCR + CD4 or CD8

42.

Which cytokine play role in T cell survival and proliferation?

a)

 IL-1

b)

IL-2

c)

IL-4

d)

IL-22

e)

IFN-gamma

43.

What type of molecular sustains that restrict to MHC molecules recognition by TCRs?

a)

Antibiotics

b)

Lipids

c)

Polysaccharides

d)

Small molecules

e)

Peptides

44.

Which organ of the peripheral lymphoid organs concentrate high number of lymphocytes?

a)

Spleen

b)

Lymph notes

c)

Bone marrow

d)

Intestines

e)

Liver

45.

Which pathogen recognition receptor that capture microbial pathogen?

a)

Toll-like receptor

b)

C type lection receptor

c)

NOD-like receptor

d)

RIG-like receptor

e)

Cystosolic DNA sensor

46.

What Ig isotype function in elimination of parasite like helminth?

a)

IgA

b)

IgD

c)

IgE

d)

IgG

e)

IgM

47.

Which region on Ig contribute to the effector function that bind to receptor or complement protein?

a)

Antigen-binding site

b)

Fab region

c)

Fc region

d)

Variable region

e)

 Light chain region

48.

What molecule sustainably express and inhibit activation in exhausted T cells?

a)

CTLA-4

b)

CD28

c)

CD40L

d)

IL-2R

e)

CD69

49.

What Ig isotype are highly abundant in heavy chain subtype and concentration in serum?

a)

IgA

b)

IgD

c)

IgE

d)

IgG

e)

IgM

50.

How subset Th cells activate B cells to produce IgE against helminth?

a)

Through secretion of IFN-LAMDA

b)

Through secretion of IL-4

c)

Through secretion of IL-5

d)

Through secretion of IL-13

e)

Through secretion of IL-17

51.

Which antibiotic peptide defense against the entering microbe at the epithelium barrier?

a)

Canthelicidin

b)

Perforin

c)

Gramzyme

d)

Ubiquitin

e)

Selectin

52.

Which ligand increase the expression of costimulators in APCs?

a)

CD40L

b)

 IFN-LAMDA

c)

TCRs

d)

Lipopolysaccharides

e)

Mannose binding lectin

53.

How infected cells activate their antiviral defense?

a)

By recognition TNF

b)

By recognition CD40L

c)

By recognition IFN-LAMDA

d)

By recognition IFN-ß

e)

By recognition IL-2

54.

What are the function of IL-10 and TGF-ß secreted from M2 macrophage in immune reaction?

a)

Enhance Phagocytosis

b)

nflammation

c)

Neutrophil response

d)

Increased epithelial integrity

e)

Anti-inflammation

55.

Which enzyme remove the nucleotides from somatic gene in the junctional diversity recombination?

a)

VDJ recombinase

b)

Ligase

c)

Exonuclease

d)

Tdt (transferase)

e)

Rnase

56.

 Which complement protein act as the opsonin and bind to microbe?

a)

Factor B protein

b)

C2 protein

c)

C3 protein

d)

C4 protein

e)

C5 protein

57.

What are the structural complex of T cell receptors?

a)

BCR + Iga + Igß

b)

TCR + CD3 + c

c)

a chain + ß2m chain

d)

a chain + ß chain

e)

TCR + CD4 or CD8

58.

Which enzyme tag and transport the cytosolic protein into the proteasome?

a)

Tapasin

b)

Chaperone

c)

HLA-DM

d)

Ubiquitin

e)

Invariant chain protein

59.

Which receptor consist of a chain and ß chain with variable and constant domains?

a)

BCR

b)

TCR

c)

class-I MHC

d)

class-II MHC

e)

IL-2R

60.

Which leukocyte cells are the most abundant in the blood circulation?

a)

NK cells

b)

B cells

c)

Macrophages

d)

Neutrophils

e)

Dendritic cells

61.

What is the role of CD28 in T cell activation?

a)

Differentiation

b)

Migration

c)

Costimulation

d)

Presentation to APCs

e)

Presentation to APCs

62.

Which T cell subset involve in innate immunity?

a)

regulatory T cell

b)

CD8+ T cell

c)

Th1 cell

d)

Th2 cell

e)

Intraepithelial T cell

63.

What is the front line barrier of the immune system?

a)

Lymphocytes

b)

Phagocytes

c)

Epithelial and mucosal fluid

d)

APC cells

e)

NK cells

64.

Which receptor consist of a chain and ß chain with antigen peptide binding cleft?

a)

Class-I MHC

b)

TCR

c)

Immunoglobulin (1g)

d)

Class-II MHC

e)

Toll-like receptor

65.

Which receptor activate signal transduction upon recognition to extracellular PAMPs?

a)

Toll-like receptor

b)

C-type lectin receptor

c)

NOD-like receptor

d)

RIG-like receptor

e)

Cystolic DNA sensor

66.

Which protein does not belong to antigen recognition receptor of T cells?

a)

CD3 protein

b)

Zeta protein

c)

CD4 or CD8

d)

TCR

e)

Iga or Igß

67.

Which subset T cell migrate to and activate B cell to produce antibodies?

a)

Th1 cell

b)

Th2 cell

c)

Th17 cel

d)

Tfh cell

e)

Regulatory T help cell

68.

Which membrane molecule that does not involve in migration T cell?

a)

CXCR3

b)

Selectin

c)

LFA-1

d)

CCR7

69.

Which cytokine differentiate proliferated Th cells into subset Thl cells?

a)

IL-1

b)

IL-4

c)

IL-6

d)

IL-22

e)

IL-23

70.

What is the costimulation receptor of CD4+ T help cells?

a)

Toll-like receptor

b)

CD28

c)

CD40L

d)

TCRs

e)

IL-2R

71.

Which receptor consist of alpha chain and ß2m protein?

a)

Immunoglobulin (Ig)

b)

Class-I MHC

c)

TCR

d)

Class-II MHC

e)

Toll-like receptor

72.

What subset of Th cell enhance eosinophils activation and killing of parasites?

a)

Th1 cell

b)

Th2 cell

c)

Th17 cell

d)

 Regulatory Th cell

73.

What is role of IL-2R in T cells?

a)

Surving

b)

Migration

c)

Recognition

d)

Activation

e)

Secretion

74.

 What is the molecular sustain that promote activated T cells exit from peripheral lymphoid organ?

a)

CXCL5

b)

CCR7L

c)

 Intergrin

d)

Sphingosine 1-phosphate

e)

ICAM-1

75.

Which receptor express lately in T cell-mediated immune response to inhibit immune response?

a)

CTLA-4

b)

CD28

c)

IL-2R

d)

CD69

e)

 CD40L

76.

What is the main effector function of NK cells in innate immune defense?

a)

Kill infiltrated microbes from epithelial barrier

b)

Antigen capture and display

c)

Endocytosis

d)

Clear cell-free antigen

e)

Kill virus-infected cells

77.

How do CD8+ CTLs kill cells infected with viruses?

a)

Through IFN-a

b)

Through lysosomal protease

c)

Through antimicrobial peptides

d)

Through membrane attack complex

e)

Through granzyme and perforin

78.

What are the two membrane Ig(s) express on maturated and selected B cells?

a)

IgD, IgE

b)

IgM, IgA

c)

IgM, IgE

d)

IgM, IgD

e)

IIgG, IgD

79.

How activated DCs choose migrate to T cell zone but not B cell zone?

a)

DCs express CXCR5

b)

 DC express B7

c)

DC express CCRF7

d)

DC express IL-12

e)

DC express class-II MHC

80.

Some virus infected cells can invade CD8+ T cell defense by inhibiting antigen displaying on MHC molecule. Then, what cells are effectively in this case?

a)

CD4+ T cells

b)

NK cells

c)

 B cells

d)

Macrophages

e)

Mast cells

81.

Which cytokines activate macrophages?

a)

IL-1

b)

TNF

c)

IFN-B

d)

IFN-LAMDA

82.

Which receptor does not involve in phagocytosis?

a)

Mannose receptor

b)

Toll-like receptor

c)

Complement receptor

d)

C-type lectin

83.

Where does B cell maturation occur?

a)

Spleen

b)

Bone marrow

c)

Lymph nodes

d)

Mucosal Tissue

84.

Which complement protein induce direct killing of microbe?

a)

C2

b)

C3

c)

 C4

d)

C5

85.

Which immune cell type does not derive from bone marrow?

a)

B lymphocyte

b)

NK cell

c)

Follicular dendritic cell

d)

Macrophage

86.

What cytokine function in antiviral defense of infected cells?

a)

 IFN-B

b)

IFN-LAMDA

c)

TNF

d)

TGF-ß

87.

Where are the mucosal tissues located?

a)

Peyer's patch

b)

Thymus

c)

Lymph node

d)

Spleen

88.

Which cytokine increase firm adhesion on phagocyte and endothelial cells?

a)

 Defensins

b)

Selectin

c)

Cathelicidins

d)

Integrin

89.

Which immune cell type does not perform antigen presentation function?

a)

Macrophage

b)

Dendritic cell

c)

B lymphocyte

d)

Neutrophil

90.

Which feature does not belong to the innate immune system?

a)

Response to diverse microbial molecules

b)

Induce inflammation

c)

Block virus replication

d)

Involve in complement system

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