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WorksheetsASTHMA/COPD THERAPEUTICS DR. ANDREWS
Total questions: 45
Worksheet time: 4hrs 17mins
Which of the following is for Preventive treatment prior to exercise for exercise-induced bronchospasm (EIB) for a short period of time?
LAMA
SABA
LABA
SAMA
Which of the following effects will have Short-Acting β2-Agonists (SABA)? Select all that apply
Hypokalemia and changes in blood glucose may occur (long-term use)
Cardiovascular effects
Hyperkalemia
Which of the following are the ADRs for Short-Acting β2-Agonists (SABA)? Select all that apply
Headache.
pain
pharyngitis and rhinitis
tachycardia
dizziness, tremor
changes in cardiac rythm
Which of the following is good for Prevention of exercise-induced bronchospasm (EIB) for a long time?
SABA
LABA
SAMA
LAMA
Which of the following is the BLACK BOX WARNING related to LABAs?
Increase the risk of embryonic related death when used alone.
Increase the risk of Heart failure related death when used alone.
Increase the risk of asthma related death when used alone.
Increase the risk of fetus related death when used alone.
LABA should not be used alone in patients with ASTHMA. It can be used adding an ICS.
True
False
Which of the following are the ADRs for Long-Acting β2-Agonists (LABA)? Select all that apply
Tachycardia, tremor
hyperglycemia
Changes in cardiac rhythm
palpitations and nervousness
hypokalemia
Which of the following are the Long-Acting β2-Agonists (LABA) approved for Both Asthma and COPD twice daily (q 12 hrs)? Select all that apply
Arformoterol
Salmeterol
Formoterol
Indacaterol
Vilanterol
Which of the following are the Long-Acting β2-Agonists (LABA) approved Only for COPD? Select all that apply
Arformoterol
Salmeterol
Formoterol
Indacaterol
Olodaterol
Which of the following drugs are considered Short-Acting Muscarinic Antagonist (SAMA)?
Tiotropium Bromide (Spiriva®) Q24H
Ipratropium (Atrovent)
Formoterol
Aclidinium (Tudorza Pressair)
Revefenacin (Yupelri) Q24H by nebulizer
Which of the following is an adverse effect for Short-Acting Muscarinic Antagonist (SAMA)?
changes in cardiac rythm
dry mouth
metallic taste
glaucoma
Which of the following are specific adverse effects for Long-Acting Muscarinic Antagonist (LAMA)? Select all that apply
upper respiratory infections
metallic taste
changes in cardiac rythm
glaucoma
A patient has been hospitalized. This patient is currently taking Aminophylline 200mg oral daily tablet , and Dr. Ritz decide to switch to Theophylline IV. What is it going to be the new dose of Theophylline for this patient in IV formulation?
Hint: ATM
250 mg IV
160 mg IV
40 mg IV
800 mg IV
A female has been discharged from the hospital. This patient was being administered Theophylline IV 300mg based on weight. Dr. Ritz decides to switch from Theophylline IV to Aminophylline oral daily tablet. What is going to be the new dose of Aminophylline for this patient?
TBW: 60 KG
IBW: 62 kg
240 mg oral
375 mg oral
1500 mg oral
60 mg oral
A female patient goes to see her doctor. The physician decides to start oral loading dose of Methylxanthine. What would be the total loading dose for this patient that the physician must prescribe?
TBW: 65 KG
IBW: 54 kg
**Note: If IBW is not given we must calculate it, using formula based on female or male:
Female IBW = 45.5 kg + 2.3 × each inch over 60"
Male IBW = 50 kg + 2.3 × each inch over 60"
325 mg oral
270 mg oral
43.2 mg oral
67.5 mg oral
Which of the following are TRUE about Methylxanthine (Theophylline)? Select all that apply
Oral loading dose: 5 mg/Kg IBW (or TBW if < IBW)
Therapeutic Range: 5-15 mcg/mL
Monitoring: Theophylline levels, HR, CNS effects (insomnia, irritability), use of rescue inhaler
Aminophylline to theophylline: Multiply by 0.8
Theophylline to Aminophylline: Divide by 0.8
Which of the following are the potential side effects for Methylxanthine (Theophylline)? Select all that apply
tachycardia
tachyarrhythmias
CNS stimulation
hyperglycemia
hypokalemia
Which of the following will DECREASE Methylxanthine (Theophylline) concentration? Select all that apply
Phenobarbital
Phenytoin
Carbamazepine
Rifampin
Smoking
Which of the following is the first line of treatment for Asthma that will help with suppression, control, and reversal of inflammation?
LAMA
LABA
ICS
Methylxanthine (Theophylline)
Dr. Andrews said to know these brand and generic only, NOT THE DOSING.
Yes
No
Which of the following adverse effects is the most common one when using ICS?
tachyarrhythmias
tachycardia
Oral thrush
CNS stimulation
glaucoma
Which of the following should be a counselling point when dispensing an ICS?
Use mouthwash before using an ICS
Rinse and spit after administration
Always brush your teeth before using an ICS
Rinse and swallow after administration for systemic effects
Which of the following are ADEs for SYSTEMIC CORTICOSTEROIDS? Select all that apply
weight gain
increase in blood glucose
fluid retention
cataracts
diabetes
The LEUKOTRIENES MODIFIERS indication is for EIB (Exercise-induced bronchospasm).
True
False
Which of the following Leukotriene Modifiers (Leukotriene receptor antagonist (LTRA):) must be dispensed in original container?
Zafirlukast (Accolate)
Montelukast (Singulair)
What should we counsel with the patient when dispensing Montelukast (Singulair®) 4mg granules?
Use within 5 hours min of opening the packet
Dissolve in small amount (5 mL) of breast milk or formula or mixed with applesauce, carrots, rice or ice cream.
Use within 115 min of opening the packet
May administer directly in the mouth
Take in the evening
Which of the following drugs has the greatest risk for serious behavior, and mood related changes, including suicidal thoughts or actions)?
Formoterol
Mometasone
Montelukast
Salmeterol
Vilanterol
Which of the following drugs has a BOX WARNING about risk of serious neuropsychiatric events, including suicidality?
Zileuton
Singulair
Mometasone
Folmoterol
Salmeterol
Which of the following is TRUE about the Immunomodulators? Select all that apply
Increase dose of corticosteroids
Decrease dose of corticosteroids
Has no effect in the dose of corticosteroids
Target specific cells/pathways to decrease symptoms associated with asthma
Which of the following Immunomodulators has to be administered in a healthcare setting and the dose is going to be dependent upon weight and IgE?
Reslizumab
(Cinqair)
Omalizumab (Xolair)
Dupilumab (Dupixent)
Mepolizumab
(Nucala)
Which of the following Immunomodulators is administered IV infusion only?
Omalizumab
(Xolair)
Mepolizumab
(Nucala)
Reslizumab
(Cinqair)
Dupilumab
(Dupixent)
Which of the following Immunomodulators is for patients ≥ 6 y/o with a positive skin test to perennial aeroallergen and inadequately controlled with inhaled corticosteroids?
Omalizumab
Mepolizumab
Reslizumab
Dupilumab
Which of the following is an anti-IgE monoclonal antibody that binds to IgE and blocks binding to receptor on mast cells and basophils –limits release of mediators of allergic response?
Mepolizumab
Omalizumab
Reslizumab
Dupilumab
Which of the following needs to be considered when dispensing Omalizumab (Xolair® )? Select all that apply
Reduced asthma exacerbations 33-75%
requires refrigeration
based on weight and pretreatment IgE levels
ADRs: Injection site reactions, malignancies, Anaphylaxis
Which of the following are Interleukin Receptor Antagonists? Select all that apply
Mepolizumab
Reslizumab
Benralizumab
Dupilumab
Omalizumab
Which of the following Interleukin Receptor Antagonists can cause Hypersensitivity reactions as an ADR?
Mepolizumab
Reslizumab
Dupilumab
Benralizumab
Which of the following Interleukin Receptor Antagonists we must treat helminth parasites before using, may need to discontinue if patient does not respond to therapy for acquired parasite infections? Select all that apply
Reslizumab
Benralizumab
Omalizumab
Mepolizumab
Which of the following Interleukin Receptor Antagonists reactivates the herpes zoster infection?
Benralizumab
Mepolizumab
Reslizumab
Omalizumab
Which of the following could be a counseling point for Mepolizumab?
patient may consider monkey pox vaccine before use
patient may consider herpes zoster vaccine before use
patient may consider chicken vaccine before use
patient may consider flu vaccine before use
Which of the following are TRUE regarding Roflumilast (Daliresp)? Select all that apply
Dose: Start at 250 mcg PO daily then ↑ 500 mcg PO daily (after 4 weeks as tolerated)
Phosphodiesterase-4 Inhibitor
relaxes smooth muscle, decreases activity of inflammatory cells and mediators
ADEs: Weight loss, decreased appetite
Always use with a long-acting bronchodilator
Which of the following are considered Meter Dose Inhalers (MDIs) that use a propellent? Select all that apply
Diskus
HFA
Respimat
Ellipta
Respiclick
Which of the following are considered Dry Powder Inhalers (DPIs) in which a spacer CANNOT BE USED? Select all that apply
Flexhaler
Respiclick
Diskus
Ellipta
Handihaler
Which of the following are TRUE about Patient Counseling for Inhalers?
Use bronchodilator first if using multiple inhalers
Cleaning the device and Priming
Rinse mouth & spit with ICS
Do not swallow capsules with Spiriva (Tiotropium)
Swallow capsules with Spiriva (Tiotropium) for better effect
Which of the following vaccines a patient with Asthma/COPD should get?
Tdap at least one dose as an adult
Influenza annually
Pneumococcal vaccines
COVID-19
Zoster
Which of the following could be used in exercise-induced bronchospasm? Select all that apply
ICS
SABA
LABA
Leukotriene modifiers
