WorksheetsABX selvam
Total questions: 17
Worksheet time: 11mins
What crucial feature of a penicillin is involved in its mechanism of action?
Thiazolidine ring
Carboxylic acid
Aromatic ring
Acyl side chain
Beta-lactam ring
WOTF statements is true for the methoxy substituent at ortho position in aromatic ring? (Methicillin)
the ortho-methoxy groups produced steric hinderance, decreasing its affinity to B-lactamases
the ortho-methoxy groups produced steric hinderance, increasing its affinity to B-lactamases
the ortho-methoxy groups produced steric hinderance, decreasing its affinity to transpeptidase
the ortho-methoxy groups produced steric hinderance, increasing its affinity to transpeptidase
WOTF statements about nafcillin is/are correct? (SATA)
Nafcillin is acid sensitive
Nafcillin is acid resistant
Ethoxy group produced steric hinderance, decreasing its affinity to B-lactamases
Nafcillin is a weak base
Nafcillin is a weak acid
Penicillin antibiotics contain:
5-membered lactam ring and 4-membered thiazolidine ring
4-membered lactam ring and 5-membered imidazole ring
4-membered lactam ring and 5-membered pyrazole ring
4-membered lactam ring and 6-membered thiazolidine ring
4-membered lactam ring and 5-membered thiazolidine ring
Beta lactam ring (penicillin) biosynthesis - condensation of:
valine + leucine
valine + cysteine
leucine + cysteine
cysteine + cysteine
WOTF statements about procaine benzyl penicillin is/are correct
water soluble and parental administration
more acid stable and acid resistant
water insoluble and used for repository purposes
beta-lactamase resistant penicillin
WOTF is/are truuu about Methicillin (SATA)?
Ortho-methoxy groups produce steric hinderance, reducing its affinity to B-lactamases
Methicillin is a weak acid
Contains beta lactam ring and thiazolidine ring
Methicillin is a B-lactamase resistant penicillin
Methicillin is an acid sensitive pencillin
WOTF is/are truuu for Ampicillin (SATA)?
weak acid
EWG (NH3+) reduces participation in acid hydrolysis
amphoteric
B-lactamase sensitive penicillin
acid resistant penicillin
WOTF is/are truuuu for Becampicillin (SATA)?
weak base
amphoteric
pro-drug
B-lactamase sensitive penicillin
acid resistant penicillin
How many chiral centers are present in Ampicillin?
3
4
5
6
WOTF is/are truuuuuu for Dicloxacillin? (SATA)
weak acid
acid resistant penicillin
B-lactamase resistant penicillin
pro-drug
isoxazole ring
WOTF is truuu for Benzyl Penicillin?
weak base
weak acid
amphoteric
neutral
WOTF is tru EXCEPT for Ampicillin?
lactam ring
B-lactamase sensitive penicillin
acid sensitive penicillin
amphoteric
4 chiral centers
WOTF is/are truuuu for Cefditoren pivoxil? SATA
B-lactam analog
Orally active prodrug
prodrug
bioavailability increased with food
achiral compound
WOTF statements is/are truuuu for Cefuroxime axetil? SATA
B-lactam analog
Z-oxime stereochemistry
prodrug
G2 cephalosporin
G3 cephalosporin
WOTF is truuuu for Cephalexin? (SATA)
G1 cephalosporin
B-lactam ring
amphoteric
3 chiral centers
weak acid
All are beta-lactamases resistant penicillins EXCEPT:
methicillin
nafcillin
ampicillin
oxacillin
dicloxacillin
