WorksheetsFundamentals of Drug Action
Total questions: 10
Worksheet time: 6mins
Nitroglycerin is not given orally because it
has a bad taste
dissolves slowly in the mouth
has a high first-pass metabolism
undergoes absorption in the stomach too quickly
A prescription for penicillin VK is given to a dental patient with an endodontic abscess. The prescription is written for an initial loading dose followed by a maintenance dose. Which of the following reasons explains the rationale for giving a loading dose for an antibiotic?
maintains a desired steady-state plasma level
attains the desired blood level immediately
decreases premature clearance of the drug
increases the rate of drug metabolism
All of the following statements are true about lipid soluble drugs except one.
Which one is the exception?
readily absorbed through blood vessel wall
slowly absorbed through cell membrane
goes through the blood brain barrier
can be given by inhalation
Which of the following routes of administration applies to Arestin?
oral
transdermal
subcutaneous
topical
Define pharmacodynamics
the action the drug has on the body and involves drug-receptor interactions, mechanisms of drug action, drug response and dose-response relationship
how the drug is absorbed, where it goes and how the body gets rid of it
the rate and the extent to which the drug is absorbed into the systemic circulation
Volume of Distribution is defined as the volume of fluid which a drug is able to distribute.
True
False
Elimination includes all of the following except...
disappearance of the active drug from the bloodstream or body
biotransformation and excretion
to be readily eliminated from the body the drug must be in a water-soluble/polar form
transfer drug throughout the body fluids to tissue and organs
Examples of a Prodrugs include all of the following except...
Amoxicillin
Codeine
Levodopa
Benazepril
Zero order kinetics is the elimination of the drug at a constant rate that does not depend upon its concentration.
True
False
The half-life of a drug is defined as
Time it takes for the concentration of the drug in the blood to fall to half (50%) of its original value
As the drug is eliminated from the body, the concentration of the drug in the plasma will decrease equally over time.
Recycling of drugs and other substances by the circulation of bile through the intestine and liver
