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Sterile Parenterals

Total questions: 34

Worksheet time: 21mins

Name
Class
Date
1.

Which of the following are considered Sterile Dosage Forms?

a)

Parenteral Injections

b)

Ophthalmic preparations

c)

Irrigation fluids

d)

Enemas

2.

This 'enforcable' chapter of the US Pharmacopeial provides the minimum practice and quality standards for compounded sterile preparations

a)

<700>

b)

<898>

c)

<797>

d)

<800>

3.

If nonsterile ingredients or equipment are used in sterile preparations, what level of risk is this considered?

a)

There is no risk with this

b)

Low risk level

c)

Medium risk level

d)

High Risk level

4.

The sterilization method of choice is often

a)

Steam

b)

Dry Heat

c)

Filtration

d)

Gas

5.

Dry heat sterilization can be used for

a)

surgical instruments

b)

glassware

c)

mineral oil

d)

glycerin

6.

The USP uses ___________ to confirm the absence of microorganisms

a)

Steam heat test

b)

Dry heat test

c)

Biological indicators

d)

Microbial markers

7.

Disadvantages of Subcutaneous injections include thrombosis, phlebitis, embolism, and infection

a)

True

b)

False

8.

Intramuscular injections typically take 10-30 minutes to work, while subcutaneous injections take approximately 30 minutes to begin working

a)

True

b)

False

9.

The following can be injected intradermally

a)

Solutions

b)

Suspensions

c)

Emulsions

d)

aerated liquids

10.

Which of the following are Solid Sterile Parenterals

a)

Lyophilized Solids

b)

Dry Powder Fill

c)

Emulsions

d)

Suspensions

11.

Which of the following are Disperse Systems Sterile Parenterals?

a)

Emulsions

b)

Suspensions

c)

Lyophilized solids

d)

Dry powder fill

12.

Water for Injections is the vehicle of choice for

a)

Freely soluble APIs (injections)

b)

Poorly water solule APIs (suspensions)

c)

The external phase for injectable emulsions

d)

Neonates

13.

Water for Injections is sterile and is used in preparation of terminmally sterilized preparations

a)

True

b)

False

14.

Sterile Water in a 1 Liter bottle cannot be administered IV due to the lack of tonicity

a)

True

b)

False

15.

Which of the following are true regarding Bacteriostatic water for injections?

a)

Compatibility of antimicrobial agents and APIs has to be considered

b)

Only for Small Volume Parenterals (~5ml)

c)

Is only available in large volumes to be drawn up in the hood

d)

Contains Sterile water for Injection + 1 or more antimicrobial agents

16.

A required labeling for Benzyl Alcohol

a)

To be kept in freezer until administration

b)

To be reconsituted before administering

c)

Not for use in NEONATES

d)

Not for use in sterile preparations

17.

Benzyl Alcohol poisoning presents as

a)

Metabolic alkalosis

b)

Hepatic cysts

c)

Gasping syndrome

d)

Myxedema coma

18.

A Large Volume Parenteral containing NaCl, KCl, and CaCl2 in water, that can act as a vehicle or as an electolyte replenisher is

a)

Ringer's Injection

b)

Lactated Ringer's Injection

19.

A Large Volume Parenteral containing salts and sodium lactate, that acts as an electolyte replenisher and systemic alkalizer is

a)

Ringer's Injection

b)

Lactated Ringer's Injection

20.

Common non-aqueous vehicles include

a)

Glycerin

b)

Alcohol

c)

Propylene glycol

d)

Sesame oil

e)

peanut oil

21.

Sterile Parenteral Dosage forms are typically

a)

Hypertonic

b)

Pyrogen Free

c)

Isotonic

d)

Capable of either immediate or prolonged action

e)

Aqueous

22.

NaCl, Glycerol, Mannitol, and Glucose are agents often used to control

a)

High pH

b)

Isotonicity

c)

Hypotonicity

d)

low pH

23.

To control pH in a sterile product, what can be used?

a)

Acetate

b)

Phosphate

c)

Citrate

d)

HCl

24.

All parenteral routes of administration are sterility demanding

a)

True

b)

False

25.

A pharmacist will be compounding a sterile preparation. Which fo the folowing is considered as a standard of practice for this activity?

a)

USP monograph 767

b)

USP monograph 795

c)

USP monograph 797

d)

USP monograph 1097

26.

A pharmacy intern is asked to compound a sterile preparation using nonsterile excipients. How would you assess the microbial contamination level of this preparation?

a)

Low risk

b)

Medium risk

c)

High risk

d)

Impossible to determine

27.

Which of the following methods of sterilization is the most appropriate for a heat sensitive API?

a)

Filtration

b)

No sterilization required

c)

Dry heat

d)

Steam

28.

Which of the following are possible complications that can arise from IV administration?

a)

Dehydration

b)

Air emboli

c)

Thrombosis

d)

Phlebitis

29.

WHich of the following solvents for injections are not suitable for use in neonates?

a)

Water for injections

b)

Sterile water for injections

c)

Bacteriostatic water for injections

30.



(a)  

31.

Which of the following are used as presevatives?

a)

Edetate Disodium

b)

Benzyl alcohol

c)

water

d)

Sodium hydroxide

32.

Polysorbate 80 can be used as

a)

Surfactant

b)

solubilizing agent

c)

vehicle

d)

pH adjuster

33.

Sodium Hydroxide can be used as a pH adjuster

a)

True

b)

False

34.

Which of the following can be used as a vehicle agent?

a)

edetate disodium

b)

water

c)

benzyl alcohol

d)

polysorbate 80

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