Worksheets2009PHM QuizIZZ 5
Total questions: 22
Worksheet time: 11mins
Which of the following is a DNA virus?
Herpes
HIV
Influenza
Covid-19
Which of the following (multiple answers possible) are caused by herpes varicella zoster?
orolabial herpes
genital herpes
shingles
herpetic eye infections
acute chickenpox
Which of the following formulations treats shingles and genital herpes?
topical aciclovir
high-dose aciclovir
IV aciclovir
oral famciclovir
foscarnet
Which enzyme is the drug target for aciclovir?
viral thymidine kinase
human DNA polymerase
viral DNA polymerase
viral protease
viral adenosine kinase
Which of the following drugs (multiple answers possible) need to be phosphorylated 3 times?
ganciclovir
zidovudine
aciclovir
foscarnet
tenofovir
Which of the following is the influenza drug target for zanamivir?
neuraminidase
M2 ion channel
thymdine kinase
DNA polymerase
RNA polymerase
Which of the following hepatitis C direct-acting antivirals inhibits the viral RNA polymerase?
NS3/4A inhibitors
NS5A inhibitors
NS5B inhibitors
NS12A inhibitors
ribavirin
Which of the following is a NUCLEOTIDE reverse transcriptase inhibitor drug?
didanosine
zidovudine
emtricitibine
lamivudine
tenofovir
In treating HIV, which THREE outcomes occur when a NTRI drug becomes phosphorylated?
It competes with the host 5'-triphosphorylated base
It inhibits HIV reverse transcriptase
It changes the conformation of reverse transcriptase
It chops up polyproteins into small proteins
It causes viral DNA chain termination
Select any of the following that are FALSE about NNRTIs such as nevirapine, efavirenz and etravirine
They are analogues of DNA/RNA bases
They change the shape of HIV reverse transcriptase enzyme
They bind to the active site of HIV reverse transcriptase
They require phosphorylation to the active form
They are prodrugs
HIV protease inhibitors block viral
maturation
condensation
polymerisation
selectivity
resistance
Which HIV drug binds to the chemokine co-receptor 5 (CCR5) located on the surface of some immune cells?
maraviroc
enfuvirtide
darunavir
didanosine
amoxicillin
WHat does the HIV drug raltegravir prevent?
Incorporation of viral DNA into host chromosomal DNA
Extension of the growing DNA chain
Conversion of inert proteins into structural and functional ones
Fusion of the HIV to the immune cell membrane
What is the MOST important reason for performing a 16-streak plating method of bacteria on agar?
To obtain single, isolated colonies
To grow bacteria
To perform a liquid dilution assay
To obtain a cloudy suspension of bacteria for further plating
Because it's fun
Which type of agar should you perform disc diffusion assays on?
Mueller-Hinton agar
Horse Blood Agar
MacConkey agar
Mannitol Salt Agar
Chocolate Agar
Which gene in MRSA produces the mutated penicillin binding protein PBP2A in MRSA strains?
mecA
mecB
mecC
mecD
mecE
Which of the following is NOT a heamolytic outcome on Horse Blood Agar plates?
α
β
γ
ψ
Which of the following is NOT a visual outcome that you could determine from a Gram stain?
cocci cells
bacilli (rod-shaped) cells
dark blue cells
pink cells
lactose fermenting cells
Ready for THREE bonus point questions?
Ya
Nah
OK
I'm just chilling really
What is the drug target of flucytosine?
cytosine deaminase
cytosine permease
cytosine reductase
cytosine polymerase
haem polymerase
Libby asks: "Which drug(s) inhibit bacterial isoleucyl transferase to halt protein synthesis?"
mupirocin
quinupristin/dalfopristin
gentamicin
chloramphenicol
tetracycline
Which type of antibiotic drug has a low immunogenic potential - so it can offer a safe alternative for people allergic to many other β-lactams?
aztreonam
piperacillin
imipenem
cefazolin
vancomycin
