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WorksheetsCase Study 5: Blood and Its Components
Total questions: 40
Worksheet time: 40mins
The process of formation and development of blood cells is termed:
Hematopoiesis
Hematemesis
Hematocytometry
Hematorrhea
During the second trimester of fetal development, the primary site of blood cell production is the:
Spleen
Lymph nodes
Liver
Bone marrow
Which one of the following organs is responsible for the maturation of T lymphocytes and regulation of their expression of CD4 and CD8?
Spleen
Liver
Thymus
Bone marrow
The best source of active bone marrow from a 20 year old would be:
Iliac crest
Femur
Distal radius
Tibia
Physiologic programmed cell death is termed:
Angiogenesis
Apoptosis
Aneurysm
Apohematics
Which organ is the site of sequestration of platelets?
Liver
Thymus
Spleen
Bone marrow
Which one of the following morphologic changes occurs during normal blood cell maturation?
Increase in cell diameter
Development of cytoplasm basophilia
Condensation of nuclear chromatin
Appearance of nucleoli
Which one of the following cells is a product of the common lymphoid progenitor?
Megakaryocyte
T lymphocyte
Erythrocyte
Granulocyte
What growth factor is produced in the kidneys and is used to treat anemia associated with kidney disease?
EPO
TPO
G-CSF
KIT ligand
Which one of the following cytokines is required very early in the differentiation of a hematopoietic stem cell?
IL-2
IL-8
EPO
FLT3 ligand
When a patient has severe anemia and the bone marrow is unable to effectively produce red blood cells to meet the increased demand, one of the body’s responses is:
Extramedullary hematopoiesis in the liver and spleen
Decreased production of erythropoietin by the kidney
Increased apoptosis of erythrocyte progenitor cells
Increased proportion of yellow marrow in the long
bones
Hematopoietic stem cells produce all lineages of blood cells in sufficient quantities over the lifetime of an individual because they:
Are unipotent
Have the ability of self-renewal by asymmetric division
Are present in large numbers in the bone marrow
niches
Have a low mitotic potential in response to growth
factors
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The hematopoietically active area of bone marrow is (are)...
yellow marrow
red marrow
storage compartments
calcified structures
Average RBC lifespan in circulation: _ days
(a)
