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WorksheetsImmu-no-sero
Total questions: 69
Worksheet time: 59mins
part of an antigen which is for specificity of the antigen
(a)
Carrier portion is responsible for (a)
The epitope of the antigen will interact to which portion
(a)
– inherent ability of a substance to induce the specific immune response resulting in the formation of immune lymphocytes or antibodies
(a)
the less foreign, the more immunogenic
(a)
Which are correctly matched?
autoantigen- elicit immune response
autoantigen- derived from other individuals
heterophile antigen- derived from other species
heterophile antigen - that exists between unrelated plants or animals
autoantigen - belongs to the body
_____ derived from identical individual ; ________ derived from non identical individual
isograft/synograft;heterograft/xenograft
heterograft/xenograft;allograft
isograft/synograft;allograft
heterograft/xenograft;isograft/synograft
the larger the molecule, the more immunogenic and the more number of (a)
immunogenic state
>10,000 daltons
<10,000 daltons
>100,000 daltons
<100,000 daltons
<10,000 daltons and needs carrier like albumin
(a)
least immunogenic and easily disintegrates
nucleic acid
polysaccharides
polypeptide
lipids
amino acids
best and strongest antigen
(a)
ability to react specifically with the antibody or cell that caused it to be produced
(a)
not all antigens are immunogens but all immunogens are antigens (true or false)
(a)
a special class of immunogen that induces hypersensitivity reactions
(a)
substances added to an immunogen to enhance immune response
(a)
The strength of the attraction between an epitope and the antigen combining site of the antibody
(a)
Refers to the strength of interaction between complex antigens and antibodies
(a)
______- simple interaction; ______- sum total interaction
avidity;affinity
affinity;avidity
affinity;specificity
specificity;avidity
aka Immuniglobulins
(a)
What type of immune response is antibody production?
humoral
cellular
both
none
defined as substances spec. glycoproteins, produced by B lymphocytes or plasma cells in response to antigenic stimulation
(a)
Which is/are incorrectly matched?
isotype-heavy chain
idiotype - hinge region
allotype - constant region
isotype - CH2
idiotype - variable region
Both light and heavy chains are held together by
(a)
treatment with (a) produces one Fc fragment and 2 Fab fragments
– responsible for specificity of antibody, antigen binding site
(a)
what portion of the variable region binds the epitope
(a)
CH2 binds with a complement protein called (a)
_____ site for heavy chain synthesis; _____site for kappa light chain; _____site for lambda light chain
Chromosome 14;Chromosome 22;Chromosome 2
Chromosome 2; Chromosome 14; Chromosome 22
Chromosome 14; Chromosome 2; Chromosome 22
Chromosome 21; Chromosome 22; chromosome 2
CH3 is involved in (a) reactions
flexible region
(a)
part of the hinge region that is responsible for its flexibility
(a)
Glycoprotein that bridges or binds monomers together
CH3
J chain
B chain
CH2
B AND C
Arrangement of IgG from most to least potent
3-2-1
2-3-1
2-1-3
3-1-2
IgM is first to appear in _____ and last to leave in _____
primary antigenic stimulus; senescence
senescence; primary antigenic stimulus
phagocytosis; primary antigenic stimulus
senescence; agglutination
exist as a _____ in plasma and a ____ in body fluids and tissues
dimer;pentamer
monomer;pentamer
monomer;dimer
pentamer;dimer
IgD is found in the surface of (a)
known as reaginic antibody
(a)
Antibody that can cross the placenta
(a)
All are characteristic of IgE except
Associated with immediate hypersensitivity
predominant in secondary immune response
elevated during parasitic infection
binds basophils and mast cells
involved in B cell activation
also known as anamnestic or memory response
(a)
Choose the ones that describes Primary response
titer increasing logarithmically in log phase
more gradual antibody catabolization during decline phase
IgG is predominant
longer LAG phase
lower antibody titer
IgM characteristics
pentameric
predominant in healthy humans
best agglutinating antibody
responsible for mucosal immunity
Adjuvant in which mycobacterium and b. pertussis underwent water-in-oil emulsion
CFA
LPS
Aluminum
Albumin
most used adjuvant in the clinical setting
(a)
description/s of carboxyterminal
with varying antibody specificity
with constant amino acid sequence
fragment crystalline
variable region
upon treating with papain, 1 fc and 2 fab are formed. Which of the ff describes fc except:
cytotropic reactions
placental transfer of antibody
cell binding
complement fixation
2 fab portion formed from papain treatment can bind antigen without the fc portion and can agglutinate and precipitate.
(a)
treatment with this agent can cause digestion of fc region, leaving 2 fab fragments that are bivalent allowing them to bind, precipitate and agglutinate
(a)
IgM is first to appear in _____ and last to leave in _____.( format: _____;______no spaces)
(a)
major Ig in secondary immune response
(a)
Major Ig in primary immune response
(a)
Which immunoglobulin/s are joined by the J chain
IgA
IgM
IgG
IgD
IgE
What stage does the antibody titer increases logarithmically?
(a)
Which immune response results to a higher antibody titer
primary
anamnestic
secondary
Which grafts are correctly matched?
autograft- from non identical individuals
isograft/syngraft - from identical individuals
syngraft - from siblings
allograft - from non identical individuals
heterograft/xenograft - from other species
all are correctly matched except? (chemical complexity)
polypeptide- Rh antigen
polysaccharide - endotoxin
nucleic acid - least immunogenic
protein - longer circulation
glycoprotein - ABO
Most common carrier protein of a hapten
(a)
allows the two Fab fragments from pepsin treatment to agglutinate, precipitate and bind to antigen.
J chain
two antigen combining sites/ bivalent
both
neither
All are functions of IgG except:
newborn immunity
mucosal immunity
complement fixation
opsonization
precipitation and agglutination
all IgG subclasses are correctly matched except:
IgG1 - 66%, 2 disulfide bonds
IgG2 - 23%, 4 disulfide bonds
IgG3 - 7%, 4 disulfide bonds
IgG4 - 4%, 2 disulfide bonds
Immunoglobulin that is anti-idiotypic
(a)
All immunoglobulins are correctly matched with their halflife, except:
IgG- 21-23 days
IgM - 21-23 days
IgA - 5-6 days
IgD- 2-3 days
IgE - 2-3 days
which immunoglobulin/s is/are correctly matched with their other name?
IgG- serum Ig
IgD- pentameric Ig
IgA- serum Ig
IgE - reagenic Ig
IgA - secretory Ig
What pathway does IgA activate?
(a)
IgD is susceptible to
(a)
most efficient to activate the complement pathway
(a)
Which of the following produces antibodies or immunoglobulins?
B lymphocytes
T lymphocytes
neutrophils
basophils
plasma cells
what type of substance is an antibody?
(a)
