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WorksheetsMacrocytic anemia
Total questions: 12
Worksheet time: 7mins
Which of the following is a key substance required for the incorporation of vitamin B12 in the nuclear synthesis of red blood cells?
EPO
Transferrin
Intrinsic factor
Homocysteine
Evidence of a megaloblastic anemia includes:
Microcytic RBCs
Thrombocytosis
Decreased red cell precursors with other cell lines unaffected
Pancytopenia
All of the following are possible causes of low levels of intrinsic factor (IF) except :
Gastrectomy
Pernicious anemia
Gastritis
Kidney failure
Which MCV range is indicative of pernicious anemia?
70 -80
85 - 95
95-105
110-120
Which of the following RBC morphologies is classic in the megaloblastic anemias?
Polychromasia
Macro ovalocytes
Macrocytes
Hypochromia
A macrocytosis that is not megaloblastic in origin can be have all of the following except:
Macrocytes
Pancytopenia
Decreased RBC count only
Hypersegmentation
Which of the following describes the ineffective erythropoiesis seen with megaloblastic anemia?
An increase in the M:E ratio
A synthetic defect in hemoglobin
Premature destruction of RBC precursors
A DNA maturation defect
Intrinsic factor is secreted by the:
Parietal cells
Ileum
Duodenum
Bone marrow
The Schilling test continues to be a historic reference method for the determination of:
IDA
Pernicious anemia
Folic acid deficiency
Non megaloblastic anemia
Macrocytic RBCs are routinely seen in all of the following except:
Pernicious anemia
Liver disease
Response to anemic stress
Thalassemia
Which of the following is a clinical symptom specific to B12 deficiency?
Fever
Numbness and trouble with balance
Pallor
Splenomegaly
All of the following may cause a non megaloblastic anemia except
Alcoholism
Pernicious anemia
Liver disease
Folate deficiency
