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WorksheetsHemolytic Anemias
Total questions: 20
Worksheet time: 11mins
These inclusions which cannot be visualized on Wright-stained peripheral smears are often associated with:
Pyruvate kinase deficiency
Basophilic stippling
Hgb H inclusion bodies
G6PD
deficiency
Which RBC morphology is formed as a result of Heinz bodies being pitted from the RBC in the spleen
acanthocytes
bite cells
burr cells
stomatocytes
Which of the following hemolytic disorders has RBCs that are especially sensitive to lysis by complement
PNH
PCH
Hereditary spherocytosis
G6PD deficiency
An anemia that manifests as decreased marrow cellularity, cytopenias in two cellular elements, and reticulocytopenia is termed
Diamond Blackfan Anemia
Aplastic anemia
Sideroblastic anemia
Hemolytic anemia
Individuals with Fanconi's anemia characteristically show
intravascular hemolysis
Increased Hgb F
Ringed Sideroblasts
Increased Hgb H
Which of the following red cell indices would most likely be found in Hereditary spherocytosis?
MCV - 87
MCH - 29.9
MCHC- 34.5
MCV - 65
MCH - 27
MCHC - 29.8
MCV - 80.5
MCH - 33.4
MCHC - 39.0
MCV 101
MCH 30
MCHC - 33.0
Choose the principal confirmation test for a diagnosis of hereditary spherocytosis
autohemolysis test
sucrose hemolysis test
thermal stability test
osmotic fragility test
Which of the following erythrocyte disorders is associated with abnormal membrane permeability?
hereditary elliptocytosis
hereditary stomatocytosis
PNH
hereditary spherocytosis
The osmotic fragility test determines whether a patient's RBCs are osmotically fragile by measuring the amount of hemolysis that occurs
after a patients RBCs have been incubated in acidified serum
when a patients RBCs have been incubated in various concentrations of hypotonic saline
after a patients RBCs have been incubated in a sucrose solution
after a patients RBCs have been incubated in their own serum for 48 hours
Immunophenotyping for a diagnosis of PNH uses the following monoclonal antibodies?
CD55 and CD59
CD11b and CD18
CD33 and CD34
CD56 and CD10
Which is the most common RBC enzyme deficiency?
pyruvate kinase
G6PD
PNH
PCH
What compound can induce anemia in G6PD deficiency?
Iron
Vitamin C
Primaquine
Fava beans
PK enzyme deficiency has this affect on the glycolytic pathway:
decreased ATP production
Heinz body formation
decreased formation of reduced glutathione
decreased formation of 2,3 -BPG
Which lab test would be most useful in diagnosing G6PD deficiency?
PEP fluorescent test
retic count
CBC
fluorescent spot test
Which of the following might be observed on a peripheral blood smear in cases of cold autoimmune hemolytic anemia:
helmet cells
macrocytes
agglutination
spherocytes
Which of the following parameters on an automated hematology instrument could be seen in cases of cold agglutinin disease:
Falsely elevated MCV
Falsely elevated RBC count
Falsely decreased RBC count
Falsely decreased MCV
The Donath-Landsteiner antibody is found in which type of hemolytic anemia?
WAIHA
PCH
CAS
PNH
The antibody found in PCH is:
IgM
IgG
directed against Rh antigens
directed against complement
What is the typical morphological classification of RBCs in aplastic anemia?
microcytic, hypochromic
normocytic, normochromic
microcytic, normochromic
macrocytic, hypochromic
Diamond Blackfan anemia involves which cell lines:
All cell lines are decreased
Only red cells are decreased
WBC and RBC are decreased
Only red cells are increased
