WorksheetsThalassemia and Hemoglobinopathy
Total questions: 20
Worksheet time: 10mins
What is the amino acid substitution in patients with sickle cell anemia?
adenine for thymine
lysine for valine
valine for glutamic acid
glutamic acid for valine
Which of the following factors contributes to the pathophysiology of sickling?
increased iron concentration
hypochromia
fava beans
dehydration
Which of the following shows crystals like those seen here
Hgb CC disease
Hgb DD disease
Hgb EE disease
Hgb SC disease
The crystals seen here are associated with:
Hgb CC disease
Hgb SS disease
Hgb SC disease
Hgb EE disease
All but one of the following may be seen in the PB smear when a sickle cell crisis has occurred
Target cells
NRBCs
Polychromasia
Moderate elliptocytes
List two sets of lab data that can distinguish IDA from beta thalassemia trait.
Serum iron and RBC
Hgb and Hct
WBC and RDW
RBC indices and Platelets
What is the majority hemoglobin in beta thalassemia major
Hgb A
Hgb A2
Hgb F
Hgb H
Which of the following alpha thalassemia is inconsistent with life?
Alpha thal trait
Alpha thal minor
Hgb H
Hgb Bart's
Which of the following hemoglobins contains β4 tetramers?
Hgb Bart's
Hgb Gower
Hgb H
Hgb Portland
Which of the following hemoglobins contains γ4 tetramers?
Hgb Bart's
Hgb Gower
Hgb H
Hgb Portland
A hemoglobin electrophoresis showed 49% Hb S, 42% Hb C, Hb F 6%, and
Hb A2 - 3%. These results are consistent with a diagnosis of:
sickle cell anemia
sickle cell trait
Hgb SC disease
Hgb C trait
A hemoglobin electrophoresis showed 40% Hb S, 57% Hb A, Hb F 1%, and
Hb A2 - 2%. These results are consistent with a diagnosis of:
sickle cell anemia
sickle cell trait
Hgb SC disease
Hgb C trait
Cells containing large amounts of Hb S sickle when which of the following conditions occur?
high oxygen tension, and acidosis
hypoxia and alkalosis
temperatures
<37 C and alkalosis
temperatures
>37 C and hypoxia
What disease does the following code for: β+ β
beta thal minor
beta thal intermedia
beta thal major
Cooley's anemia
Which nationality is MOST likely to be affected by thalassemia?
Chinese
South American Indians
Southeast Asians
Europeans
Which of the following lab results would be expected in a patient with alpha thalassemia?
MCH = 32 pg
MCV = 70 fl
stomatocytes
Increased Hgb A
Which thalassemiapresents with an abnormal hgb that precipitates in red cells and will have a golf ball appearance after incubation with brilliant cresyl blue
Hgb F
Hgb H
Hgb Bart's
Beta thal major
Why is hydrops fetalis incompatible with life?
Life cannot exist without HbA
Lack of embryoinc hemoglobins precludes fetal development
All three normal adult hemoglobins contain alpha chains
Fetal hgb is essential to sustain life after birth
What disease does the following code for: αα/- -
Aphal thal trait
Alpha thal minor
Hgb H
Hgb Bart's
What disease does the following code for: α-/- -
Aphal thal trait
Alpha thal minor
Hgb H
Hgb Bart's
