NEW
Font size
Worksheets1.6 Acute Leukemias
Total questions: 24
Worksheet time: 12mins
1. Auer rods may be seen in all of the following except:
A. Acute myelomonocytic leukemia (M4)
B. Acute lymphoblastic leukemia (ALL)
C. Acute myeloid leukemia without maturation (AML:M1)
D. Acute promyelocytic leukemia (PML; M3)
2. Which type of anemia is usually present in a patient with acute leukemia?
A. Microcytic, hyperchromic
B. Microcytic, hypochromic
C. Normocytic, normochromic
D. Macrocytic, normochromic
3. In leukemia, which term describes the peripheral blood finding of leukocytosis with a shift to the left, accompanied by NRBCs?
A. Myelophthisis
B. Dysplasia
C. Leukoerythroblastosis
D. Megaloblastosis
4. The basic pathophysiological mechanisms responsible for producing signs and symptoms in leukemia include all of the following except:
A. Replacement of normal marrow precursors by leukemic cells causing anemia
B. Decrease in functional leukocytes causing infection
C. Hemorrhage secondary to thrombocytopenia
D. Decreased erythropoietin production
5. Which type of acute myeloid leukemia is called the true monocytic leukemia and follows an acute or subacute course characterized by monoblasts, promonocytes, and monocytes?
A. Acute myeloid leukemia, minimally differentiated
B. Acute myeloid leukemia, without maturation
C. Acute myelomonocytic leukemia
D. Acute monocytic leukemia
6. In which age group does ALL occur with the highest frequency?
A. 1–15 years
B. 20–35 years
C. 45–60 years
D. 60–75 years
7. Disseminated intravascular coagulation (DIC) is most often associated with which of the following types of acute leukemia?
A. Acute myeloid leukemia, without maturation
B. Acute promyelocytic leukemia (PML)
C. Acute myelomonocytic leukemia
D. Acute monocytic leukemia
8. An M:E ratio of 10:1 is most often seen in:
A. Thalassemia
B. Leukemia
C. Polycythemia vera (PV)
D. Myelofibrosis
9. Which of the following is a characteristic of Auer rods?
A. They are composed of azurophilic granules
B. They stain positive on periodic acid–Schiff (PAS) staining
C. They are predominantly seen in chronic myelogenous leukemia (CML)
D. They are nonspecific esterase positive
10. SITUATION: The following laboratory values are seen:
WBC = 6.0 × 109/L Hgb = 6.0 g/dL RBC = 1.90 × 1012/L Hct = 18.5% PLT = 130 × 109/L
Serum vitamin B12 and folic acid: normal
These results are most characteristic of:
A. Pernicious anemia
B. Acute myeloid leukemia, without maturation
C. Acute erythroid leukemia
D. Acute myelomonocytic leukemia
11. A 24-year-old man with Down syndrome presents with fever, pallor, lymphadenopathy, and hepatosplenomegaly. His CBC results are as follows:
WBC = 10.8 × 109/L RBC = 1.56 × 1012/L
8% PMNs Hgb = 3.3 g/dL
25% lymphocytes Hct = 11%
67% PAS-positive blasts PLT = 2.5 × 109/L
These findings are suggestive of:
A. Hodgkin lymphoma
B. Myeloproliferative disorder
C. Leukemoid reaction
D. Acute lymphocytic leukemia
12. SITUATION: A peripheral blood smear shows 75% blasts. These stain positive for both Sudan Black B (SBB) and peroxidase. Given these values, which of the following disorders is most likely?
A. Acute myelocytic leukemia (AML)
B. CML
C. Acute undifferentiated leukemia (AUL)
D. ALL
13. In myeloid cells, the stain that selectively identifies phospholipid in the membranes of both primary and secondary granules is:
A. PAS
B. Myeloperoxidase
C. SBB
D. Terminal deoxynucleotidyl transferase (TdT)
14. Sodium fluoride may be added to the naphthyl ASD acetate (NASDA) esterase reaction. The fluoride is added to inhibit a positive reaction with:
A. Megakaryocytes
B. Monocytes
C. Erythrocytes
D. Granulocytes
15. Leukemic lymphoblasts reacting with anti–common acute lymphoblastic leukemia antigen (anti-CALLA) are characteristically seen in:
A. B-cell ALL
B. T-cell ALL
C. Null-cell ALL
D. Common ALL
16. Which of the following is often associated with CML but not with AML?
A. Infections
B. WBCs greater than 20.0 × 109/L
C. Hemorrhage
D. Splenomegaly
17. A patient’s peripheral blood smear and bone marrow both show 70% blasts. These cells are negative on SBB staining. Given these data, which of the following is the most likely diagnosis?
A. AML
B. Chronic lymphocytic leukemia (CLL)
C. Acute PML
D. ALL
18. Which of the following leukemias are included in the 2008 World Health Organization classification of myeloproliferative neoplasms (MPN)?
A. CML
B. Chronic neutrophilic leukemia (CNL)
C. Chronic eosinophilic leukemia (CEL)
D. All of these options are classified as MPN
19. In addition to morphology, cytochemistry, and immunophenotyping, the WHO classification of myelo- and lymphoproliferative disorders is based on which characteristic?
A. Proteomics
B. Cytogenetic abnormalities
C. Carbohydrate-associated tumor antigen production
D. Cell signaling and adhesion markers
20. The WHO classification requires what percentage for the blast count in blood or bone marrow for the diagnosis of AML?
A. At least 30%
B. At least 20%
C. At least 10%
D. Any percentage
21. What would be the most likely designation by the WHO for AML M2 by the FAB classification?
A. AML with t(15;17)
B. AML with mixed lineage
C. AML with t(8;21)
D. AML with inv(16)
22. What would be the most likely designation by the WHO for AML M3 by the FAB classification?
A. AML with t(15;17)
B. AML with mixed lineage
C. AML with t(8;21)
D. AML with inv(16)
23. Which AML cytogenetic abnormality is associated with AML M4 with marrow eosinophilia under the WHO classification of AML with recurrent genetic abnormalities?
A. AML with t(15;17)
B. AML with mixed lineage
C. AML with t(8;21)
D. AML with inv(16)
24. What would be the most likely classification by the WHO for AML M7 by the FAB classification?
A. Acute myeloid leukemias with recurrent genetic abnormalities
B. Acute myeloid leukemia with multilineage dysplasia
C. Acute megakaryoblastic leukemia classified under AML (not otherwise categorized)
D. Acute leukemias of ambiguous lineage
