WorksheetsFinal exam review
Total questions: 54
Worksheet time: 54mins
First pass metabolism affects which of the following properties of drugs?
Bioavailability
Color
Taste
Duration of effect
Which of these are extravascular routes of drug administration ? SELECT ALL THAT APPLY
Intramuscular testosterone injection
Propofol injection in the veins
Digoxin injection in the heart
Insulin inhaler
Fentanyl is more potent and efficacious than tramadol.
True
False
Maximum volume of an injection that can be given subcutaneously is?
5 mL
1 mL
10 mL
0.2 mL
Drug from which of the following dosage forms will show the fastest absorption?
Powder
Tablet
Capsule
Transdermal patch
........................... mixture is a homogeneous mixture that has a melting point lower than those of the constituents.
eutectic
hygroscopic
efflorescent
deliquescent
Which of the following statement is most accurate about hard and soft gelatin capsules. SELECT ALL THAT APPLY
Soft gelatin cannot be compounded, hard ones can be
Hard gelatin have less moisture than soft gelatin
Hard and soft gelatin both can encapsulate aqueous liquids
Both should not be stored in the bathroom
The largest capsule size is
0
5
8
000
Which of the following type of tablets dissolve and release the drug over time?
Buccal
Lozenges
Effervescent
Sublingual
Enteric coated tablets disintegrate in the stomach so the drug can be absorbed at the acidic pH
True
False
Which of the following excipients aid in the breaking of the tablet in the body ?
Glidant
Binder
Surfactant
Disintegrant
Which of the following cannot be included as a sweetener in a patient with phenylketonuria and has IBS? SELECT ALL THAT APPLY
Sorbitol
Saccharin
Aspartame
Dextrose
Which of the following statements is most accurate about brand vs generic tablets?
Brands are always covered by insurance, while generics are not
Brands are always cheaper than generics
Both has the same API but could have a different packaging
Brands are always more efficacious than generic ones
For which of the following drug scenarios would you think of developing a modified release tablet? SELECT ALL THAT APPLY
Drug with half life of 17 h
Drug for chronic pain
Not very narrow therapeutic index
Drug with an immediate release tablet dose of 650 mg, given 4 times a day
Which of the following is true regarding ghost tablets?
One that has partial amount of drug within the shell
Empty shell and no drug in it
All modified release tablets are ghost tablets
These are placebo tablets
Which of the following types of modified release tablets show a zero order drug release pattern?
Drug embedded in a hydrophilic matrix
Drug embedded in a plastic matrix
Osmotic tablets
Ion-exchange resins
Which of the following best describes the role of disodium EDTA in a liquid solution?
Vehicle
Preservative
Sweetener
Chelator
An ideal suspension has which of the following properties? SELECT ALL THAT APPLY
Settles slowly
Caking
REdispersability
Particles of wide range of size
Which of the following will decrease the rate of settling in a suspension?
Increasing particle size
Increasing dispersion medium viscosity
Increasing particle density
Decreasing dispersion medium viscosity
To formulate a o/w emulsion, which of the following emulsifying agents can be used based on their HLB?
HLB of 10
HLB of 20
HLB of 1
HLB of 4
With regards to the 4:2:1 methods for preparing emulsions with fixed oils, which of the following are accurate? SELECT ALL THAT APPLY
Refers to the ratio of oil, water, and gum to prepare primary emulsion
Applies to both, dry and wet gum method
If 30 g oil is used, 2 g of water and 1 g of gum will be used
If 60 g oil is used, 30 g of water and 15 g of gum will be used
Which of the following excipients is essentially required for preparation of emulsions using oil and water?
Flocculating agent
Emulsifier
Chelating agent
Anti-oxidants
Which of the following is the primary factor that determines the BUD of a product?
Water activity
Presence of an oil
Area of application
Sterilization method used
Which of the following are biocides? SELECT ALL THAT APPLY.
Sanitizer
Hand wash
Ampicillin
Sodium benzoate
If a biocides's concentration is increased 2 fold, how will the rate of kill change if its concentration exponent is 3
Increase 8 times
Decrease 4 times
Remain unchanged
Increase 9 times
Which of the following are ways to prevent contamination of parenterals in the manufacturing area? SELECT ALL THAT APPLY
Use of clean rooms
HEPA filters
Sterilization
Maintaining positive air pressure
Which of the following options are correct regarding the comparison of single-dose and multiple dose vials? SELECT ALL THAT APPLY.
Both contain preservatives
Multiple dose are made of bacteriostatic water for injection
Both are hermetically sealed
Single dose are always sterilized by autoclaving, while multiple dose by dry heat
3-in-1 TPN consists of one bag that has a milky appearance.
True
False
Which of the following is true about the clean room specifications. SELECT ALL THAT APPLY.
Higher the ISO number, cleaner the room
ISO #5 = class 100 area (US Federal Standards)
Lower the ISO number, higher the number of particles allowed
Which of the following may be used when a product cannot be decontaminated at the end?
Sterility assurance test
Terminal sterilization
Reverse osmosis
Aseptic manufacturing
Which of these is true about ophthalmic preparations? SELECT ALL THAT APPLY.
Are always sterile
Sodium chloride may be added for isotonicity adjustment
Can not be made in a suspension form
Formulated at a pH of 7.4
Which of the following is true with regards to the pH of the otic, ophthalmic, and nasal preparations.
Eye drops must have a pH of 7.4 if possible; alkaline pH is better handled by the eye
Nasal preparations must have a pH of 5.5-6.5
Ear drops must have a pH of 3-4
All the other are true
Which of the following routes can be used to deliver the drug, locally as well as systemically? SELECT ALL THAT APPLY
Nasal
Ophthalmic
Inhalational
Otic
Which of the following is true regarding application of nasal and ear products. SELECT ALL THAT APPLY.
Pump based nasal sprays are applied with head bent forward.
Nasal drops are applied to the patient lying flat on the back and head tilted back
It is acceptable to use ear drops in the eyes.
For children more than 4 years old, the ear is pulled downwards and backwards.
Which of the following is true about nasal sprays?
Higher surface tension, higher viscosity and droplet size
More viscosity, finer mist
Short aerosol plumes are better for nasal deposition
Which of the following inhalational devices are propellant-based? SELECT ALL THAT APPLY.
MDI
Soft-mist inhaler
Nebulizer
Dry powder inhaler
Which of the following statements is correct regarding metered dose inhalers and nebulizers?
Spacer devices may be needed with a nebulizer
Coordination between breathing in and actuation of the device is important for MDIs, but not nebulizers
MDIs may be preferred more for pediatrics than a nebulizer
Nebulizers use propellants, MDIs use external compressor
Lipophilic drugs must be incorporated in cocoa butter suppositories?
True
False
Which of the following can be used as a primary vehicle/base for making ointments as well as suppositories?
Polyethylene glycol
glycerin
Propylene glycol
Gelatin
Which of the following patient counseling points are important when dispensing suppositories? SELECT ALL THAT APPLY
Remove the foil and then insert
Appropriate storage conditions
Won't be any need to remove from the body as the suppositories will melt over time
Not for ORAL use
Which of the following methods for compounding suppositories involves melting the base and calibration of molds ?
Hand rolling
Double casting
Fusion method
Compression
Topical drug delivery= localized drug action
Transdermal drug delivery= ?
Lymphatic
Systemic
Muscular
Subcutaneous
The outermost layer of the skin which also acts as a barrier to drug delivery is?
Stratum basale
Stratum corneum
Dermis
Hypodermis
Which of the following are correct regarding commercially available transdermal patches? SELECT ALL THAT APPLY
Scopolamine patches are worn for 3 days
7 day clonidine patches are available
Used fentanyl patches must be flushed down the toilet
All transdermal patches can be cut.
True
False
Which of the following techniques make micron sized channels in the skin? SELECT ALL THAT APPLY
Microneedles
Laser
Iontophoresis
Chemical enhancers
Which of the ointment bases are the least cosmetically appealing?
absorption
water-removable bases
water-soluble bases
oleaginous
Which of the following topical products can be applied preferably to the scalp?
Ointments
Gels
w/o creams
o/w creams
It is acceptable to apply an occlusive dressing on a topical glucocorticoid.
True
False
Mixing of the ingredients in parts for uniform mixing while compounding ointments is referred to as?
Trituration
Levigation
Pulverization
Geometric dilution
Which of the following are accurate regarding augmented topicals? SELECT ALL THAT APPLY.
Contain glycerin
contain propylene glycol
Penetrate deeper than regular versions
Are less irritating
Which of the following phenomenon are indicative of instabilities in gels?
syneresis
swelling
change in color
All the above
Which of the following drugs may be able to passively cross the stratum corneum?
Dibenzoylmethane (log P of 4)
Baclofen (log P is -0.78)
Diclofenac (Log P: 4.5)
Tenofovir (log P of 2.2)
Topical delivery system that tends to show a Newtonian rheological flow is which of the following?
Creams
Lotions
Gels
Ointments
