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WorksheetsNarcotic Analgesics + NSAIDs
Total questions: 16
Worksheet time: 8mins
Identify the drug given below
Ibuprofen
Indomethacin
Naproxen
Sulindac
Mefenamic acid belongs to which chemical class of anti-inflammatory agents?
Heteroaryl acetic acid derivatves
Heteroaryl propionic acid derivatves
Enolic acid derivative
Anthranilic acid derivative
Incorporating a cyclopropylmethyl substitution at the 17th position of the multicyclic opioid ring leads to ______
Agonistic activity predominates
Reduced affinity to receptor
Antagonistic activity predominates
Mixed acting action
Which of the isomer of Sulindac is more active?
R isomer
S isomer
E isomer
Z isomer
Which of the following is a narcotic antagonist?
Levorphanol
Meperidine
Naloxone
Fentanyl
Biologic activity of Ibuprofen resides almost exclusively in the ______ isomer
S-(-)
S-(+)
R-(+)
R-(-)
Meperidine undergoes which Phase 1 metabolic reaction
Reduction
Oxidation
N - dealkylation
O - methylation
Naturally occurring morphine has _____ absolute configuration
5R,6S,9R,13S,14R
5R,6R,8R,13R,14R
5R,6S,9R,13S
2R,6S,9R,13S,14R
The _____ found in naturally occuring morphine is engaged in a hydrogen bond with a µ-receptor Asn residue
14α - OH
6β - OH
6α - OH
14β - OH
The anilidopiperidines are commonly known as _____
morphinans
benzomorphans
Fentanyls
Morphines
Which of the following is a flexible µ agonist?
Naloxone
Codeine
Methadone
Morphine
Which of the following is NOT an opioid based anti-diarrheal?
Loperamide
Diphenoxylate
Difenoxin
Meperidine
Which of the drugs possess analgesic and antipyretic actions but lack anti-inflammatory effects
Ibuprofen
Diclofenac
Piroxicam
Acetaminophen
What is the category of the following drug?
Multicyclic µ agonist
Flexible µ agonist
Flexible µ antagonist
µ antagonist
Which of the following is an incorrect pair of NSAIDs
Indole acetic acid: Diclofenac
Pyrazoles and Pyrazolidinediones: Phenylbutazone
p-aminophenols: acetaminophen
salicylates: aspirin
Which of the following NSAID is a prodrug?
Ibuprofen
Indomethacin
Naproxen
Sulindac
