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Clinical Virology

Total questions: 15

Worksheet time: 8mins

Name
Class
Date
1.

Which of the following is appropriate for the viruses that are obligate intracellular parasites?

a)

Do not possess active protein synthesizing apparatus.

b)

Replicate outside the host cell.

c)

  Metabolically active outside the host

d)

Possess active protein synthesizing apparatus

e)

Unique replication apparatus

2.

Virus types are very specific, and each has a limited number of hosts it can infect. What would be the best choice for the above statement?

a)

Antigenic shift

b)

Host interaction

c)

Viral hepatocytes

d)

Viral tropism

e)

Viral infection

3.

     The protein coat of viruses that encloses the genetic material is referred to as:

a)

Capsid

b)

Capsomers

c)

Naked

d)

Peplomers

e)

Viroid

4.

Which of the following viruse is sensitive to heat, drying, pH, detergents, and lipid solvents such as alcohol?

a)

Adenovirus

b)

 Papillomavirus

c)

HCV

d)

Rhinovirus

e)

HAV

5.

The glycoprotein of the influenza virus plays a crucial role in the early stage of virus infection. Which one of the following is associated with infection?

a)

Glycan

b)

Hemagglutinin

c)

Mucin

d)

N-linked glucan

e)

S protein

6.

Which of the following statements is best for a positive-strand RNA virus?

a)

It must first be converted to an mRNA before it can be translated

b)

It can be used directly to translate viral proteins.

c)

It will be degraded by host enzymes

d)

It is not recognized by host ribosomes

e)

Must generate mRNAs for protein synthesis

7.

Which of the following gives the virus symmetry?

a)

arrangement of amino acid

b)

arrangement of capsomers

c)

arrangement of capsid

d)

arrangement of glycan

e)

arrangement of ribosomes

8.

Hepatitis delta virus only occurs in patients who also have either acute or chronic infection with hepatitis B virus. What would be the best choice for the Hepatitis delta virus?

a)

Defective RNA virus

b)

Hepatitis B mutant

c)

Incomplete hepatitis B virion

d)

Pseudovirion

e)

Related to hepatitis A virus

9.

Infectious particles are composed solely of protein and no detectable nucleic acid. What would be appropriate according to the statement?

a)

Celiac Disease

b)

Creutzfeldt-Jacob Disease

c)

Hemolytic Anemia

d)

Hepatitis Delta Virus

e)

Plant diseases

10.

Which of the following infectious agents do not have nucleic acid?

a)

 Naked

b)

Prions

c)

Provirus

d)

Viroids

e)

Viruses

11.

The positive RNA genome is not translated but is converted into DNA, which then acts as a template for the production of mRNA. Which virus is most likely to be represented?

a)

Adenovirus

b)

Picornavirus

c)

Papillomavirus

d)

Retrovirus

e)

Rhinovirus

12.

Which one of the following is appropriate regarding the infectious circular RNA particles without the protein coat?

a)

Virion

b)

Viroid

c)

Virusoid

d)

Prion

e)

HDV

13.

Which of the following statements are appropriate regarding antigenic drift?

a)

It results in major antigenic changes

b)

It is exhibited by only influenza A viruses

c)

It is due to genetic variation

d)

It affects predominantly the matrix protein

e)

It results in new subtypes over time 

14.

Which of the following swabs inhibits the replication of some viruses and can interfere with nucleic acid amplification tests?

a)

Dacron

b)

Dacron rayon

c)

Calcium

d)

Calcium alginate

e)

Rayon

15.

For virus identification, specimens should never be stored at −20° C. Which one of the following statements is true?

a)

Formation of ice crystals that will disrupt host cells and loss of viral viability

b)

Formation of ice crystals that will disrupt the RBC and result in hemolysin

c)

Formation of ice crystals that will disturb host cells protein

d)

Formation of ice crystals that will rupture host red blood cells

e)

Formation of ice crystals that will rupture host cells protein