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Clinical Toxicology Part I

Total questions: 100

Worksheet time: 50mins

Name
Class
Date
1.

Antidote for iodine poisoning:

a)

silver nitrate

b)

potassium nitrate

c)

starch

d)

sugar

2.

The specific antidote for the treatment of poisoning due to oral ingestion of silver nitrate would be the oral administration of :

a)

acetic acid solution

b)

sodium bicarbonate

c)

normal saline

3.

This is recommended in phenol poisoning as a cathartic but is contraindicated in poisoning by chlorinated insecticide, since it may increase intestinal absorption

a)

magnesium sulfate

b)

mannitol

c)

castor oil

d)

Fleet’s Phospho-soda

4.

The most serious potential consequence of ingestion of liquid hydrocarbon such as kerosene or gasoline is:

a)

paralysis of the peristaltic motion of the GI tract

b)

the aspiration of the poison into the respiratory tract

c)

destruction of body enzymes by the poison

5.

Death may result from poisoning due to the following causes, except:

a)

due to interference with the carriage of oxygen

b)

due to inhibition of the respiratory movements by neuro muscular agents

c)

due to interference with the enzyme system utilizing it

d)

circulatory failure as a result of cardiac glucosides

6.

Streptomycin can cause:

a)

4th cranial damage

b)

8th cranial damage

c)

7th cranial damage

d)

6th cranial damage

7.

A poison which increases suddenly in its intensity of action after slow or gradual addition of it is

a)

corrosive poison

b)

true poison

c)

cumulative poison

d)

irritant poison

8.

Antidote for iodine poisoning:

a)

silver nitrate

b)

potassium nitrate

c)

starch

d)

sugar

9.

A specialized field of toxicology that designates an area of professional emphasis within the realm of medical science.

a)

Forensic toxicology

b)

Environmental toxicology

c)

Clinical toxicology

d)

Regulatory toxicology

10.

The quantity of medicine that can kill an organism

a)

fatal dose

b)

Teratology

c)

LD50

d)

Threshold Limit Value

11.

The ff. are mechanism of poison absorption, except:

a)

hydrolysis

b)

filtration

c)

endocytosis

d)

passive diffusion

12.

Constipation caused by active charcoal can be relieved by concomitant administration of

a)

glycerol

b)

laxative

c)

water

d)

none of the above

13.

The percentage of oxygen which is indicated for carbon dioxide poisoning to increase the conversion of carboxyhemoglobin to hemoglobin and myoglobin and to increase oxygen saturation of the plasma is:

a)

50%

b)

100%

c)

75%

d)

10%

14.

Activated charcoal may be used in the treatment of these poisoning, except

a)

Phenobarbital

b)

aspirin

c)

propoxyphene

d)

methanol

15.

Dryness of the mouth is a side effect of:

a)

atropine

b)

acetaminophen

c)

aspirin

d)

cimetidine

16.

These statements regarding carbon monoxide poisoning are true except:

a)

the oxygen carrying capacity of the blood is decreased

b)

the oxyhemoglobin dissociation curve becomes shifted to the left, releasing less oxygen to the tissues

c)

carboxyhemoglobin level of less than 30% produces minimal symptoms

d)

treatment with 100% carbon dioxide is effective

17.

It is known as the Neutral spirit

a)

aniline

b)

iodine

c)

formaldehyde

d)

ethyl alcohol

e)

cyanide

18.

It is also known as the stink damp

a)

hydrogen sulfide

b)

carbon disulfide

c)

carbon monoxide

d)

nitrogen oxide

19.

It is used in the manufacture of smoke bomb, antiseborrheic shampoos, in the treatment of bone fracture and rickets.

a)

bismuth

b)

cesium

c)

boron

d)

chromium

e)

cadmium

20.

Direct hepatotoxicity has been observed with the ff. anesthetic agents:

a)

halothane

b)

thiopental

c)

nitrous oxide

d)

all of the above

21.

It is used in fingerprint photography

a)

nitrite

b)

lead

c)

naphthalene

d)

mercury

e)

oxalate

22.

It is the most toxic metal

a)

nitrite

b)

arsenic

c)

beryllium

d)

oxalate

e)

naphthalene

23.

Ammonium salt is the antidote for

a)

aniline

b)

cyanide

c)

iodine

d)

formaldehyde

e)

ethyl alcohol

24.

Methylene blue is the antidote for

a)

aniline

b)

iodine

c)

cyanide

d)

ethyl alcohol

e)

formaldehyde

25.

Deferoxamine is an antidote for:

a)

iron

b)

calcium

c)

methanol

d)

iodine

26.

A type of poison that causes blackening and severe corrosion in the mouth:

a)

nitric acid

b)

phenol

c)

sulfuric acid

d)

hydrochloric acid

e)

ascorbic acid

27.

Effective therapy to rattle snake bite:

a)

suction and tourniquet

b)

antivenin, suction and tourniquet

c)

antivenin

d)

none of these

28.

It is the poison in toilet bowl deodorant:

a)

nitrite

b)

naphthalene

c)

lead

d)

oxalate

29.

An antidote to methanol poisoning:

a)

ethanol

b)

atropine

c)

digoxin

d)

naloxone

30.

Induction of vomiting is accomplished by administering:

a)

syrup of ipecac

b)

peppermint syrup

c)

ginger ale

d)

none of these

31.

Poisoning due to anticholinesterase is best managed by the administration of:

a)

theophylline

b)

salbutamol

c)

atropine

d)

ethanol

32.

A carcinogenic substance found in stale peanut:

a)

peroxide

b)

aflatoxin

c)

glyceryl ester

d)

fatty acid

33.

The universal antidote usually contains tannic acid, activated charcoal and:

a)

calcium hydroxide

b)

magnesium hydroxide

c)

aluminum hydroxide

d)

all of these

34.

Black widow spider venom is called:

a)

neostigmine

b)

carbachol

c)

lactrotoxin

d)

all of these

35.

Litharge is also known as:

a)

magnesium oxide

b)

arsenic trioxide

c)

lead oxide

d)

nitrous oxide

36.

Manihotoxin found in this crop root:

a)

yam

b)

sweet potatoes

c)

cassava

d)

none of these

37.

Best known physiological antidote for strychnine:

a)

codeine

b)

barbiturate

c)

pilocarpine

d)

morphine

38.

Principal active alkaloid of ipecac:

a)

caffeine

b)

ergonovine

c)

apomorphine

d)

emetine

39.

It causes shellfish toxicity:

a)

dinoflagellates

b)

jellyfish

c)

snails

d)

octopus

40.

A common household substance given as antidote is milk because:

a)

it is amphoteric and coats the

b)

it is amphoteric stomach

c)

coats the stomach

d)

none of these

41.

Saxitoxin is the poison found in:

a)

mushroom

b)

marine animal

c)

dried nuts

d)

snake

42.

A branch of toxicology which is concerned with the medical and legal consequences of poisoning:

a)

environmental toxicology

b)

forensic toxicology

c)

experimental toxicology

d)

economic toxicology

43.

Mechanism of action of mineral oil as antidote for poisoning by kerosene

a)

adsorption

b)

neutralization

c)

inactivation

d)

lessen respiratory hazard by increasing viscosity of kerosene

44.

Side-effects frequently seen with benzodiazepines, except:

a)

ataxia

b)

seizures

c)

drowsiness

d)

none of these

45.

A botanical insecticide:

a)

malathion

b)

parathion

c)

pyrethrum

d)

none of these

46.

The effects that occurs at the site of the first contact between the biological system and the toxicant.

a)

local toxicity

b)

systemic toxicity

c)

economic toxicity

d)

cumulative toxicity

47.

Intermediate acting barbiturate/s, except:

a)

amobarbital

b)

pentobarbital

c)

butabarbital

d)

vinbarbital

48.

Insecticide, fungicide, alloys in medicine, emetic drug, astringent and caustic, purification of water, escharotic

a)

a. cadmium

b)

copper

c)

none of these

d)

lead

e)

mercury

49.

Cocaine is commonly known as:

a)

coke

b)

crystals

c)

lady

d)

all of the above

50.

Specific antidote for silver poisoning

a)

lemon juice

b)

ammonia

c)

saline solution

51.

The cardinal rule or the first step to be considered in the treatment of poisoning is to:

a)

remove the poison from contact with the victim

b)

stop the action of the poison by giving the specific antidote

c)

provide symptomatic or supportive care

d)

fight against the tendency of death

52.

Substance intend to prevent, destroy, repel or mitigate rats, mice, etc.

a)

a. herbicides

b)

redenticides

c)

hematocides

d)

molluscides

53.

Characteristic odor of phosphorous intoxication:

a)

garlic odor

b)

odor of bitter almonds

c)

mousey odor

54.

The mechanism by which 70% ethyl alcohol may act as a disinfectant is attributed to:

a)

a metabolic degradation product of ethyl alcohol

b)

the lack of alcohol dehydrogenase in bacterial cells

c)

the inebriating effect of ethyl alcohol on cells

d)

the ability of ethyl alcohol to denature proteins

55.

Source of phytotoxin:

a)

animals

b)

minerals

c)

plants

d)

insects

56.

The organ of elimination for metallic poison:

a)

mouth

b)

liver

c)

rectum

d)

skin

57.

The first toxic symptoms of digitalis poisoning is:

a)

gastrointestinal irritation

b)

cerebral excitement

c)

undue depression of heart rate

d)

colored vision

e)

flushing of skin

58.

Atropine poisoning can be antagonized by:

a)

Pralidoxime

b)

Phentolamine

c)

Neostigmine

d)

Isoproterenol

59.

The following symptoms of poisoning from Antimony (Sb) are similar to those of arsenic poisoning, except:

a)

diarrhea of rice-water stool

b)

severe dehydration and great thirst

c)

garlic odor of the breath and suppression of urine

d)

nausea and vomiting

60.

Metallic poisons are classified as:

a)

corrosive poison

b)

cerebral neurotic poisons

c)

irritant poison

d)

all of the above

61.

Prussian blue is the antidote for what poisoning?

a)

lithium

b)

thallium

c)

nitrites

d)

cyanide

62.

Which of the following can be used for carbamate poisoning:

a)

Pralidoxime

b)

Atropine

c)

Neostigmine

d)

all of the above

63.

Causes liquifaction necrosis:

a)

silicones

b)

alkali

c)

acids

d)

paraquat

64.

Ecstacy is related to what drug:

a)

amphetamine

b)

acetylcholinesterases

c)

opiods

d)

anorectic

65.

FPN Test indicates the presence of:

a)

Chlorpromazine

b)

Ferric chloride

c)

Imipramine

d)

Salicylic acid

66.

Triad of opiod/opiate toxicity, except:

a)

respiratory depression

b)

convulsion

c)

pin-point pupil

d)

coma

67.

Toxic metabolite of CCl4

a)

epoxides

b)

nitrite

c)

phosgene

d)

cyanide

68.

Poison from black widow spider:

a)

a-latro toxin

b)

a-bungarotoxin

c)

saxitoxin

d)

picrotoxin

69.

The process of detoxification where in the drug/substance of abuse is withdrawn gradually:

a)

”cold turkey”

b)

“lukewarm turkey”

c)

“warm turkey”

d)

“hot turkey”

70.

“Angel dust:”

a)

MDMA

b)

PCP

c)

LSD

d)

THC

71.

“Roofies:”

a)

alprazolam

b)

flunitrazepam

c)

cannabis

d)

heroin

72.

Present in tear gas:

a)

cyanide

b)

alloin

c)

capsaicin

d)

cysteine sulfoxide

73.

Warfare gas:

a)

Phosgene

b)

Sarin

c)

COCl2

d)

all of the above

74.

A patient passing out a yellow-green vomitus can be poisoned by:

a)

iron

b)

phosphorous

c)

chromium

d)

cyanide

75.

A characteristic of arsenic poisoning:

a)

black gum lines

b)

Mees’ lines

c)

wrist drop

d)

acrodynia

76.

The major target organ of toxicity of benzene:

a)

blood

b)

bone marrow

c)

liver

d)

heart

77.

Signs of barbiturate poisoning:

a)

Alkalosis

b)

decrease respiratory minute volume

c)

diuresis

d)

hypertension

78.

Angina pectoris is a type of pain seen in this type of poisoning:

a)

Hydrochloric acid

b)

Mercury

c)

Lead

d)

Nicotine

79.

Nicotinic acid produces which of the following effects:

a)

decreases VLDL clearance

b)

increases VLDL clearance

c)

increases production of VLDL

d)

none of these

80.

The organs adversely affected by lead, except:

a)

brain c.

b. d.

b)

blood

c)

kidneys

d)

lungs

81.

Enhancement of elimination of poisoning include:

a)

manipulation of urine pH to accelerate urinary excretion

b)

hemoperfusion

c)

hemodialysis

d)

all of these

82.

The most toxic veratrine alkaloid is:

a)

pseudoveratrine

b)

veratrine

c)

protoveratrine

d)

pseudogerbine

83.

Atropine is useful in treating poisoning by organophosphate insecticide because it:

a)

stimulates receptors directly

b)

reactivates inhibited acetylcholinesterase

c)

blocks the action of acetylcholine at both central and peripheral sites

d)

inhibits normal ganglionic transmission

84.

Caffeine can cause:

a)

respiratory paralysis

b)

drowsiness

c)

restlessness

d)

all of these

85.

Antidote for monomethylhydrazine:

a)

pyridoxine

b)

riboflavin

c)

thiamine

d)

all of these

86.

An antidote for curare poisoning:

a)

Atropine

b)

Homatropine

c)

Neostigmine

d)

all of these

87.

Rotten egg odor is a characteristic of:

a)

heroin poisoning

b)

lead

c)

hydrogen sulfide

d)

ethylene glycol

88.

An antidote that acts by adsorption and is usually given when the nature of poison is unknown:

a)

Potassium permanganeate

b)

Tannic acid

c)

Ipecac syrup

d)

Charcoal

89.

Also known as knock out drops:

a)

chloroform

b)

chloral hydrate

c)

trichloromethane

d)

phenol

90.

The primary toxicity of carbon tetrachloride

a)

nephrotoxicity

b)

cardiotoxicity

c)

hepatoxicity

d)

pulmonary toxicity

91.

Agents which produce stupor:

a)

abortives

b)

narcotics

c)

stimulants

d)

convulsants

92.

The best method of isolating non-volatile poisons is by:

a)

distillation with a current of steam

b)

distillation without current steam

c)

extraction with water or oxalic acid

d)

extraction with organic acids

93.

Distinguishing test of carbon disulfide from hydrogen sulfide:

a)

Sulphocyanate test

b)

Xanthogenate test

c)

hypochlorite test

94.

Aniline + bromine water gives this characteristic precipitation:

a)

pinkish-red precipitate

b)

blue-green precipitate

c)

flesh-colored precipitate

d)

yellowish-globules

95.

A type of poisoning produced by taking or absorbing for a protracted period small doses of a poison, thereby producing gradual deterioration of function of tissues:

a)

acute poisoning

b)

chronic poisoning

c)

sub-acute poisoning

d)

none of the above

96.

Dose which may be expected ordinarily to produce the therapeutic effects for which the preparation is employed:

a)

maximum dose

b)

average dose (median)

c)

minimum dose

d)

above average dose

97.

Atmospheric substance with an oxidizing power which liberate iodine from the solution of KI:

a)

carbon monoxide

b)

ozone

c)

oxidants

d)

hydrogen sulfide gas

98.

This substance is produced by the incomplete combustion of carbon or carbonaceous materials:

a)

nitrogen materials

b)

carbon monoxide

c)

sulfur oxide

d)

hydrogen sulfide

99.

Characteristic color of the ammonium phosphor-molybdate precipitate for the presence of phosphorous:

a)

violet precipitate

b)

yellow precipitate

c)

black precipitate

d)

maroon precipitate

100.

Characteristic type of precipitate of magnesium ammonium phosphate for the presence of phosphorous:

a)

curdy, white precipitate

b)

crystalline, white precipitate

c)

heavy, white precipitate

d)

white solution

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