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Hypersensitivity and Autoimmune Disease

Total questions: 42

Worksheet time: 42mins

Name
Class
Date
1.

commonly called allergies, occur within minutes after exposure to antigen

a)

Type I (Immediate)

b)

Type II (antibody-mediated)

c)

Type III (immune complex mediated)

d)

Type IV (hypersensitivity)

2.

cytolysis due to ab and complement

a)

Type I (Immediate)

b)

Type II (antibody-mediated)

c)

Type III (immune complex mediated)

d)

Type IV (hypersensitivity)

3.

deposition of antigen-antibody complexes

a)

Type I (Immediate)

b)

Type II (antibody-mediated)

c)

Type III (immune complex mediated)

d)

Type IV (hypersensitivity)

4.

characterized by tissue damage due to inflammatory responses

* release of cytokines by sensitized T cells

a)

Type I (Immediate)

b)

Type II (antibody-mediated)

c)

Type III (immune complex mediated)

d)

Type IV (hypersensitivity)

5.

* hay fever, asthma, eczema, atopic dermatitis, anaphylaxis to drugs, food allergies, allergy to animals and animal products

a)

Type I (Immediate)

b)

Type II (antibody-mediated)

c)

Type III (immune complex mediated)

d)

Type IV (hypersensitivity)

6.

* leprosy, tuberculin, hashimoto's, poison ivy, type 1 DM, acute and chrinic graft rejection

a)

Type I (Immediate)

b)

Type II (antibody-mediated)

c)

Type III (immune complex mediated)

d)

Type IV (hypersensitivity)

7.

* drug-induced hemolytic anemia, HDN, hyperacute graft rejection, goodpasteur syndrome, rheumatic fever, myasthenia gravis, grave's, type 2 DM

a)

Type I (Immediate)

b)

Type II (antibody-mediated)

c)

Type III (immune complex mediated)

d)

Type IV (hypersensitivity)

8.

* SLE, RA, post streptococcal, glomerulonephritis, vasculitis, serum sickness

a)

Type I (Immediate)

b)

Type II (antibody-mediated)

c)

Type III (immune complex mediated)

d)

Type IV (hypersensitivity)

9.

Effector Cells:

Basophil, Mast Cell

a)

Type I

b)

Type 2

c)

Type 3

d)

Type 4

10.

Effector Cells:

PMN, NK, Microorganism

a)

Type I

b)

Type 2

c)

Type 3

d)

Type 4

11.

Effector Cells:

PMN, Microorganism

a)

Type I

b)

Type 2

c)

Type 3

d)

Type 4

12.

Effector Cells:

T cell

a)

Type I

b)

Type 2

c)

Type 3

d)

Type 4

13.

expression of the immune response that occurs when the body’s self tolerance system fails. The body’s immune cells are no longer able to recognize “self” – those antigens are self-molecules phenomenon referred to as “self-tolerance”. This can result in unrelated diseases known as autoimmune diseases.

(a)  

14.

* Paroxysmal cold hemoglobinuria

* Warm autoimmune haemolytic anemia (AIHAs)

* Immune thrombocytopenic purpura (ITP)

a)

Hematologic disorders

b)

Endocrine disorders

c)

Neuromuscular disorders

d)

Renal disorders

e)

Gastrointestinal disorders

15.

* Grave's disease

*Hashimoto's thyroiditis

* Insulin - dependent diabetes mellitus

a)

Hematologic disorders

b)

Endocrine disorders

c)

Neuromuscular disorders

d)

Renal disorders

e)

Gastrointestinal disorders

16.

*Myasthenia gravis

* Multiple sclerosis

a)

Hematologic disorders

b)

Endocrine disorders

c)

Neuromuscular disorders

d)

Renal disorders

e)

Gastrointestinal disorders

17.

*Goodpasteur's syndrome

*Tubulo-interstital nephritis

a)

Hematologic disorders

b)

Endocrine disorders

c)

Neuromuscular disorders

d)

Renal disorders

e)

Gastrointestinal disorders

18.

*Pernicious anemia

*Primary biliary cirrhosis

a)

Hematologic disorders

b)

Endocrine disorders

c)

Neuromuscular disorders

d)

Renal disorders

e)

Gastrointestinal disorders

19.

A disease that can damage the joints, skin, kidneys, heart, lungs, and other parts of the body.

a)

Systemic Lupus Erythematosus

b)

Scleroderma

c)

Ankylosing Spondylitis

d)

Sjogren's Disease

e)

Grave's disease

20.

A disease causing abnormal growth of connective tissue in the skin and blood vessels.

a)

Systemic Lupus Erythematosus

b)

Scleroderma

c)

Ankylosing Spondylitis

d)

Sjogren's Disease

e)

Grave's disease

21.

A form of chronic inflammation of the spine and the sacroiliac joints

a)

Systemic Lupus Erythematosus

b)

Scleroderma

c)

Ankylosing Spondylitis

d)

Sjogren's Disease

e)

Grave's disease

22.

a disease in which the immune system targets the glands that make moisture, such as tears and saliva

a)

Systemic Lupus Erythematosus

b)

Scleroderma

c)

Ankylosing Spondylitis

d)

Sjogren's Disease

e)

Grave's disease

23.

a disease that causes the thyroid to make too much thyroid hormone

a)

Systemic Lupus Erythematosus

b)

Scleroderma

c)

Ankylosing Spondylitis

d)

Sjogren's Disease

e)

Grave's disease

24.

A disease in which the immune system attacks the lining of the joints throughout the body

a)

Rheumatoid arthritis

b)

Infectious Mononucleosis

c)

Pernicious Anemia

d)

Myasthenia Gravis

25.

* causative agent is Epstein Barr virus

* Presence of "Downey cells"

* EBV infection is most common during adolescence and early adulthood

a)

Rheumatoid arthritis

b)

Infectious Mononucleosis

c)

Pernicious Anemia

d)

Myasthenia Gravis

26.

Condition that manifests in individuals (small percent) who have severe chronic gastritis

a)

Rheumatoid arthritis

b)

Infectious Mononucleosis

c)

Pernicious Anemia

d)

Myasthenia Gravis

27.

A disease in which the immune system attacks the nerves and muscles throughout the body

a)

Rheumatoid arthritis

b)

Infectious Mononucleosis

c)

Pernicious Anemia

d)

Myasthenia Gravis

28.

typically seen in RA, drug-induced SLE, Sjogren's syndrome & MCTD

a)

Homogeneous (solid, diffuse)

b)

Peripheral/Rim (Ring, membranous)

c)

Speckled (mottled, "pepper dots")

d)

Nucleolar

e)

Anti-Centromere Antibody (ACA)

29.

associated with SLE in the active stage and Sjogren disease

a)

Homogeneous (solid, diffuse)

b)

Peripheral/Rim (Ring, membranous)

c)

Speckled (mottled, "pepper dots")

d)

Nucleolar

e)

Anti-Centromere Antibody (ACA)

30.

associated with Scleroderma, Sjogren's SLE and Raynaud's phenomenon

a)

Homogeneous (solid, diffuse)

b)

Peripheral/Rim (Ring, membranous)

c)

Speckled (mottled, "pepper dots")

d)

Nucleolar

e)

Anti-Centromere Antibody (ACA)

31.

Crest variant of scleroderma

a)

Homogeneous (solid, diffuse)

b)

Peripheral/Rim (Ring, membranous)

c)

Speckled (mottled, "pepper dots")

d)

Nucleolar

e)

Anti-Centromere Antibody (ACA)

32.

* Sheep RBCs - LATEX coated with denatured gamma globulin

* False (+) - SLE, Sjogren's, Syphilis, Hepatitis

a)

Rapid agglutination test

b)

Bentonite Flocculation

c)

Anti-CCP (Cyclic citrullinated peptide)

33.

generally considered a positive reaction

a)

Titer of 80 or greater

b)

Titer of 20 to 40

c)

1:20

34.

considered a weakly positive reaction

a)

Titer of 80 or greater

b)

Titer of 20 to 40

c)

1:20

35.

no agglutination, specimen should be considered negative for RF even if subsequent dilution shows agglutination

a)

Titer of 80 or greater

b)

Titer of 20 to 40

c)

1:20

36.

affects potentially reactive N cells and T cells as they mature in the bone marrow and thymus

a)

Central tolerance

b)

Peripheral tolerance

37.

occurs in the secondary lymphoid organs

a)

Central tolerance

b)

Peripheral tolerance

38.

a diffuse, granular staining of the cytoplasm of the neutrophils, mainly caused by antibodies against PR3 and seen in the vast majority of patients with active systemic GPA

a)

c-ANCA

b)

p-ANCA

39.

characterized by fluorescence surrounding the nuclear lobes of ethanol - fixed neutroppgils, caused by antibodies to positively charged antigens such as MPO

a)

c-ANCA

b)

p-ANCA

40.

anti-dSDNA antibodies

a)

SLE

b)

RA

c)

Grave's disease

41.

antibodies against the TSH

a)

SLE

b)

RA

c)

Grave's disease

42.

anti-CCP (cyclic citrullinated proteins)

a)

SLE

b)

RA

c)

Grave's disease

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