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WorksheetsBIOCEL 04
Total questions: 20
Worksheet time: 15mins
Name
Class
Date
1.
Gold nanoparticles below a certain size limit that are injected into the cytoplasm can later be observed in the nucleus. This is explained by which of the following:
a)
Molecules below a certain size can diffuse nonselectively through the nuclear pore complex.
b)
There are gold-specific ion channels on the nuclear envelope.
c)
Gold particles contain a nuclear localization signal.
d)
The DNA requires gold to function effectively.
e)
Gold is recognized as valuable and is escorted into the nucleus by a nuclear transport receptor.
2.
The carbohydrate groups found on the extracellular surface of the plasma membranes were 'installed' by cellular machinery__________.
a)
on the luminal side of the ER and Golgi membranes.
b)
in the cytosol.
c)
on the cytosolic side of the ER and Golgi membranes.
d)
on the luminal side of the ER membrane and the cytosolic side of the Golgi membrane.
e)
on the cytosolic side of the ER membrane and the luminal side of the Golgi membrane.
3.
A transmembrane protein destined for the plasma membrane protrudes from the cytosolic face of the ER membrane. On its journey to its destination, where would you expect the protein to protrude?
a)
on the cytosolic face of the Golgi, and on the cytosolic face of the plasma membrane
b)
on the non-cytosolic face of the Golgi, and on the extracellular face of the plasma membrane
c)
on the non-cytosolic face of the Golgi, and on the cytosolic face of the plasma membrane
d)
on the cytosolic face of the Golgi, and on the extracellular face of the plasma membrane
e)
I have absolutely no idea.
4.
HsDynamin-1
a)
is involved in Clathrin-mediated endocytosis.
b)
is responsible for cleaving the stretch amino acid sequence 'sorting signals' from N-terminals of proteins once the sorting process is completed in eukaryotic cells.
c)
I have absolutely no idea.
d)
depicts a paradigmatic endogenous theory scenario
e)
is envolved in re-targeting or relocalization of proteins to different compartments
5.
Stages in vesicle delivery:
a)
Tethering-Docking-Fusion
b)
Docking-Tethering-Fusion
c)
Docking-Fusion-Tethering
d)
Fusion-Docking-Tethering
e)
Tethering-Fusion-Docking
6.
Key proteins in vesicular movement are:
a)
All answers are correct
b)
Rab
c)
Snare
d)
tSNARE
e)
vSNARE
7.
An adapter protein__________.
a)
All answers are correct
b)
is on the coat of a vesicle
c)
binds to sorting signal in the transmembrane protein
d)
couples transmembrane protein with protein coat of budding transport vesicle
e)
is regulated by ARF and Rab
8.
COP I and COP II:
a)
COP I coated vesicles travel from the Golgi to the ER and COP II coated vesicles travel from the ER to the Golgi.
b)
COP I coated vesicles travel from the ER to the Golgi and COP II coated vesicles travel from the Golgi to the ER.
c)
are two clathrin proteins that coat transport vesicles
d)
are regulated by ARF and Rab
e)
None of the answers are correct
9.
membrane protein that acts with some other membrane protein that has to be binded for HIV to enter. CXCR4 and CCR5
a)
Co-Receptor
b)
Receptor
c)
vSNARE
d)
tSNARE
e)
vSNARE is binded to vesicle, tSNARE is on membrane where Tethering occurs
10.
In Vesicular transport, budding _________________.
a)
releases material out of the organelle
b)
releases material inside the nucleus
c)
releases material inside the Golgi
d)
releases material inside the ER
e)
I have absolutely no idea
11.
The Region of the ER from which Proteins EXIT for the Golgi Apparatus.
a)
Transitional ER
b)
Autophagosome
c)
Signal peptidase
d)
Golgi stack
e)
Signal patch
12.
A modified Mannose residue that targets Proteins to Lysosomes.
a)
Mannose-6-Phosphate
b)
Endosome
c)
Exocyst
d)
Secretory Pathway
e)
Phagosome
13.
The Compartments of the Golgi Apparatus w/in which most Metabolic Activities take place.
a)
Golgi Stack
b)
Synaptic Vesicle
c)
SNARE
d)
Flippase
e)
Mannose-6-Phosphate
14.
A Particle composed of Proteins & RNA that Binds to Signal Sequences & Targets Polypeptide Chains to the Endoplasmic Reticulum.
a)
Signal Recognition Particle (SRP)
b)
Mannose-6-Phosphate
c)
Clathrin-Coated Vesicle
d)
ER-Associated Degradation (ERAD)
e)
SRP RNA
15.
A vesicle containing internal organelles enclosed by fragments of cytoplasmic membranes that fuse with lysosomes
a)
Autophagosome
b)
Lysosome
c)
Peroxisome
d)
Phagosome
e)
All answers are correct
16.
Lysosomes participate in these cellular processes:
a)
All answers are correct
b)
Endocytic, Phagocytic, Autophagy and Biosynthetic degradation processes
c)
Cell migration
d)
Cholesterol transport
e)
Antigen presentation
17.
Lysosome movement towards the microtubule plus-ends _______ and minus-ends _________ is mediated by kinesin and dynein motors
a)
anterograde / retrograde
b)
retrograde / anterograde
c)
Both are anterograde
d)
Both ate retrograde
e)
Lysosomes do not move at all
18.
Lysosomes may fuse with the plasma membrane during:
a)
All answers are correct
b)
Cell injury
c)
Phagolysosome biogenesis
d)
Formation of autolysosomes
e)
Response to a rise in cytosolic Ca2+
19.
What is the function of lysosomes in addition to terminal degradation?
a)
Killing of intracellular pathogens
b)
Production of energy
c)
Regulation of cell division
d)
Synthesis of proteins
e)
All answers are correct
20.
What is the effect of lysosome dysfunction on disease?
a)
It underlies rare lysosome storage disorders
b)
It has no effect on disease
c)
It only affects lysosome motility
d)
It underlies more common diseases, such as cancer and neurodegeneration
e)
All answers are correct
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