Endogenous lipids are produced in what part of the body?

Defined as acute coronary syndromes, a history of myocardial infarction, stable or unstable angina, coronary or other arterial revascularization, stroke, transient ischemic attack, or peripheral arterial disease of atherosclerotic origin.

Defined as chronic, progressive disease characterized by the accumulation of fatty and fibrous material in the innermost layer of arteries that results in the formation of atherosclerotic plaques.

What transports lipids into the tissues?

What is the most abundant atherogenic lipoprotein?

Long term exposure to LDL-C is a key predictor of ASCVD risk.

Reducing LDL-C can slow the progression of plaque volume but does not regress plaque volume.

In individuals without established ASCVD but at high risk of an ASCVD event, low or moderate risk factor modification is a priority

What is the indication of Sybrava?

What is the recommended dose of Sybrava?

Dose adjustment is required for patients with mild to moderate hepatic impairment.

For patients on dialysis taking Sybrava, hemodialysis should not be performed for at least how many hours?

What is the most common adverse event of Sybrava?

Which of the following describes inclisiran?

Following a single subcutaneous administration of 284 mg of inclisiran, LDL-C reduction was apparent within how many days post-dose?

Inclisiran binds with what receptor via 3x-GAlNac?

As inclisiran enters the cytoplasm, it is loaded onto what type of complex?

What cleaves the passenger strand and separates it to the guide strand as inclisiran is loaded onto the RISC?

Inclisiran prevents the synthesis of PCKS9 resulting to more LDL-C receptors and increased uptake of LDL.