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Glycogen, Glycolysis, and Gluconeogenesis - Corso - Endo exam 2

Total questions: 27

Worksheet time: 17mins

Name
Class
Date
1.

Match the following Glucose transporters with where they are found in cells

a)

Most tissues and RBCs

1.

Glut1

b)

Found in neurons of the brain

2.

Glut3

c)

Found in muscle and adipose

3.

Glut4

d)

Found on lumen side of intestine

4.

Glut5

e)

Found in liver, intestine, and pancreases

5.

Glut2

2.

Which of the following is insulin sensitive?

a)

Glut1

b)

Glut2

c)

Glut3

d)

Glut4

e)

Glut5

3.

Which of the following is the main transporter moving high glucose levels to the liver

a)

Glut1

b)

Glut2

c)

Glut3

d)

Glut4

e)

Glut5

4.

Which of the following is the enzyme used for glucose phosphorylation in the liver, kidney, and pancreases

a)

Glucokinase

b)

Hexokinase

c)

Phosofructokinase

d)

Enolase

5.

Which of the following is the enzyme used for glucose phosphorylation in majority of our cells

a)

Glucokinase

b)

Hexokinase

c)

Phosofructokinase

d)

Enolase

6.

Which of the following enzymes can be used for this reaction (SATA)

a)

Glucokinase

b)

Hexokinase

c)

Phosofructokinase

d)

Enolase

7.

MODY can best be described as a

a)

Glucokinase deficiency

b)

Hexokinase deficiency

8.

What would be the product of the reaction shown?

a)

Fructose

b)

Glucose-1-phosphate

c)

Glucose-6-phosphate

d)

Galactose

9.

To convert glucose-6-phosphate to glucose-1-phosphate which reversibly enzyme is used

a)

Glucokinase

b)

Hexokinase

c)

Phosphoglucomutase

d)

Enolase

10.

What enzyme is used in this reversible reaction

a)

Glycogen synthase

b)

glucokinase

c)

Phosphoglucomutase

d)

UDP-glucose pyro phosphorylase

11.

When glycogen synthase is present what will happen when UDP-glucose and the glycogen chain are present

a)

Glycogen (n+1) and UDP formed

b)

Glycogen (n-1) and UDP form

c)

UDP cleaves a sugar of the glycogen chain

d)

No reaction

12.

Which of the following reactions is reversible and promoted by insulin signaling in the liver? (Select all that apply)

a)

Glucokinase

b)

Phosphoglucomutase

c)

UDP-glucose Pyrophosphorylase

d)

Glycogen synthase

13.

All of the following are seen in Anderson's disease EXCEPT

a)

Fasting hypoglycemia

b)

Enlarged liver

c)

Enlarged spleen

d)

Can affect muscle, heart and brain in some cases

14.

Match the following

a)

Type 0 disorder

1.

Glycogen synthase deficiency

b)

Anderson's disease

2.

Branching enzyme deficiency

c)

MODY

3.

Glucokinase deficiency

d)

Hemolytic anemia of RBC

4.

Hexokinase deficiency

e)

Cori disease

5.

Debranching enzyme deficiency

15.

Match the following diseases with their enzyme impacted

a)

Glycogen phosphorylase issue leading to hypoglycemia and liver enlargment

1.

Hers Disease

b)

Glycogen phosphorylase with muscle weakness

2.

McArdle's Disease

c)

Glucose-6-phosphatease

3.

Von Gierke disease

d)

Debranching enzyme

4.

Cori Disease

e)

Phosphofructokinase-1

5.

Tarui syndrome

16.

Insulin

a)

Promotes glycogen breakdown

b)

Promotes glycogen synthesis

17.

Glucagon

a)

Promotes glycogen breakdown

b)

Promotes glycogen synthesis

18.

Which of the following diseases leads to an enlarged liver, fasting hypoglycemia, and excessive glycogen storage in the liver

a)

Her's Disease

b)

McArdle's Disease

c)

Pompe's Disease

d)

Anderson's disease

19.

Which of the following diseases leads to muscle fatigue and excessive glycogen stored in the muscle

a)

Her's Disease

b)

McArdle's Disease

c)

Pompe's Disease

d)

Anderson's disease

20.

Which of the following diseases leads to lysosomal storage disorder

a)

Her's Disease

b)

McArdle's Disease

c)

Pompe's Disease

d)

Anderson's disease

21.

Which of the following diseases leads an enlarged liver due to reduced glycogen branching

a)

Her's Disease

b)

McArdle's Disease

c)

Pompe's Disease

d)

Anderson's disease

22.

Which of the following diseases leads to enlarged liver, fasting hypoglycemia, excess normal glycogen in the liver all due to high glucose-6-phosphate levels

a)

Von Gierkes Disease

b)

McArdle's Disease

c)

Pompe's Disease

d)

Anderson's disease

e)

Cori's Disease

23.

Which of the following diseases leads to enlarged liver, fasting hypoglycemia, muscle fatigue, and short branched glycogen in the liver and muscles

a)

Von Gierkes Disease

b)

McArdle's Disease

c)

Pompe's Disease

d)

Anderson's disease

e)

Cori's Disease

24.

Which of the following leads to decreased movement of glucose into and out of the liver

a)

Type zero glycogen storage disorder

b)

Glut1 transporter deficiency

c)

Glut4 transporter deficiency

d)

Glut2 Transporter deficiency

25.

Which of the following leads to decreased movement of glucose into and out of muscles and fat cells

a)

Type zero glycogen storage disorder

b)

Glut1 transporter deficiency

c)

Glut4 transporter deficiency

d)

Glut2 Transporter deficiency

26.

Which of the following leads to decreased movement of glucose entry into the brain

a)

Type zero glycogen storage disorder

b)

Glut3 transporter deficiency

c)

Glut4 transporter deficiency

d)

Glut2 Transporter deficiency

27.

Which of the following leads to decreased glycogen synthesis and fasting hypoglycemia

a)

Type zero glycogen storage disorder

b)

Glut1 transporter deficiency

c)

Glut4 transporter deficiency

d)

Glut2 Transporter deficiency

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