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WorksheetsCancrinase
Total questions: 18
Worksheet time: 15mins
Name
Mention your region (HQ of your RM)
Zone (North/South/East/West)
Which of the following are the biomarkers for ALL?
Common acute lymphoblastic leukemia antigen (Calla)
EGFR
Terminal deoxynucleotidyl Transferase (TdT)
KIT gene
T-cell is the most common type of ALL, comprising 85-90 % of ALL cases in children. True or False
TRUE
FALSE
One possible symptom of acute leukemia is bruising or bleeding easily.
True
False
PegAspargenase suppress tumor growth by ___________
Increasing protein biosynthesis
Starving tumor cell of asparagine
Blocking enzyme aspargenase
None of the above
Pegaspargase is the only PEGylated asparaginase approved by both the FDA and the EMA.
True
Flase
Lyophilized Pegaspargase offers _____________.
extended shelf life
sustained asparagine depletion
lower immunogenicity
All of the above
During IM administration of Cancrinase, the volume injected at one site should not exceed________ in children.
5 ml
3 ml
2 ml
0.9 ml
The efficacy of pegaspargase as a first-line treatment in pediatric patient was supported by ___________.
DFCI 05‑001 Trial
COG AALL0331
HERA trial
All of the above
After reconstitution, Cancrinase can be stored at ________ for ______ hours.
RT, 24 hours
2 - 8⁰ C, 8 hours
2 - 8⁰ C, 48 hours
Cannot be stored after reconstitution.
Which of the following is the advantage of pegaspargase over non-pegylated aspargenase?
Patient convenient dosing
Low immunogenicity
Sustained asparaginase depletion
All of the above
Dosage of Cancrinase in children above 21 years of age is __________ IV/IM.
2,000 IU/m
2,500 IU/m
3750 IU/m
750 IU/m
Which of the following are the competitors of Cancrinase.
Hamsyl
Asviia
Peg Lasgen
Eleftha
MRP of Cancrinase is Rs. ________.
21200
22000
25000
22100
Which of the following molecules is not a treatment option for ALL along with Pegaspargase?
Vincristine
Epirubicin
Doxorubicin
Cyclophosphamide
Cancrinase and Innovator shows similar ___________ profile.
Pharmacological
degree of pegylation
safety
physiochemical
