After administration of the loading dose and seven doses (1500 mg each) at 12-hour intervals, plasma vancomycin concentrations are determined to be 44 mg/L (2 hours after the end of the 2-hour infusion) and 16 mg/L at the end of the dosing interval. 

What is the half-life of vancomycin (in hr) in this patient?

(a)  

Calculate the Ke (in hr-1) for a patient that will be initiated on vancomycin using the equation Ke = 0.00083/hr x CrCl + 0.0044 for a 45-year-old man, 5' 10'' tall, weighing 73 kg (IBW = 73 kg), serum creatinine concentration of 1.00 mg/dL.

Ke = 0.00083/hr x CrCl + 0.0044 

(a)  

BW, a 42-year-old man, 5' 10'' tall, weighing 75 kg (IBW = 73 kg), needs to receive a loading dose of vancomycin (25 mg/kg) that will be infused over 2 hours.  

Calculate the loading dose for this patient in mg. For grading purposes do not round.

(a)  

A patient is receiving 750 mg of vancomycin every 12 hours by 1-hour infusion. A steady state trough concentration is measured  0.5 hours before a dose and reported as  12 mg/L. You wish to raise the trough to  17.5 mg/L. 

What dose (rounded to nearest mg) would you suggest if the interval would remain at 12 hours?

(a)  

A patient is receiving 750 mg of vancomycin every 12 hours by 1-hour infusion. A steady state trough concentration is measured  0.5 hours before a dose and reported as  12 mg/L. You wish to raise the trough to  17.5 mg/L. 

What dosing interval should you use if you wish to keep the dose at 750 mg? Do not round

(a)  

E.K., a 60-year-old, 50-kg woman with a serum creatinine of 1.0 mg/dL, has been empirically started on 750 mg of vancomycin every 12 hours. A culture indicates that the infection is caused by MRSA with an MIC of 1.0 mg/L. Design a dose in mg to be administered every 24 hr that will produce therapeutic vancomycin concentrations and an AUC₂₄/MIC ≥ 400 for E.K. You have calculated her patient specific K = 0.054 hr-1 and V_d = 34.8 L.

       AUC₂₄/MIC = X₂₄ / (Cl x MIC)

(a)  

DJ is a 56-year-old, 76-kg (height = 6 ft 1 in) male with MRSA pneumonia (MIC = 1 μg/mL). His current serum creatinine is stable at 1.5 mg/dL. A vancomycin dose of 1000 mg every 24 hours was prescribed. After the third dose, the steady-state trough concentration equaled 7 μg/mL. Based on this you calculate the patient's AUC₂₄/MIC = 265. Compute a new vancomycin dose in mg that would provide an AUC₂₄/MIC > 400

(a)  

RI is a 55-year-old, 78-kg (height = 6 ft 1 in) male with an MRSA pneumonia (MIC = 1μg/mL). A vancomycin dose of 1000 mg every 12 hours was prescribed and expected to achieve an AUC₂₄/MIC > 400. After the third dose, the steady-state peak and trough concentration equaled 24 μg/mL and 9 μg/mL, respectively. The dose was infused over 1 hr with a waiting period of 1/2 hour before the peak concentration was obtained. Calculate the AUC₂₄/MIC for this patient using AUC₂₄ = (AUC_inf + AUC_elim ) x # doses.

(a)