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WorksheetsDrugs for Peptic Ulcer Disease
Total questions: 25
Worksheet time: 9mins
The following is true about antacids EXCEPT:
They are given after meals
It can cause metabolic alkalosis
Acts on the channels at the parietal cells
Neutralizes acid for up to 2 hours
The following adverse effects are CORRECTLY matched EXCEPT:
Sodium - water retention
Magnesium - LBM
Aluminum - diarrhea
Calcium - milk alkali syndrome
A patient develops confusion, gynecomastia, and decreased libido while on ulcer therapy. Which drug is MOST likely responsible?
Ranitidine
Famotidine
Nizatidine
Cimetidine
Histamine release comes from which cells?
G cells
D cells
ECL cells
Parietal cells
When should proton pump inhibitors be given?
After breakfast
Before breakfast
Any time of the day
Before bedtime
What is the effect of pantoprazole in clopidogrel activation?
It increase clopidogrel activation
It decreases clopidogrel activation
It initially decreases clopidogrel activation then increase
It has minimal to no effect on clopidogrel activation
Which among the drugs for peptic ulcer disease is most effective in inhibiting 24-hour acid secretion?
Antacids
H2-Receptor Antaognists
Proton Pump Inhibitors
Sucralfate
This mucosal protective agent causes blackening of stool and darkening of tongue.
Sucralfate
Misoprostol
Rebamipide
Bismuth
Why are PPIs administered 30–60 minutes before meals?
Faster gastric emptying
Prevent degradation by food
Maximize inhibition of actively secreting pumps
Reduce adverse effects
The following is part of the triple therapy EXCEPT:
Tetracycline
Clarithromycin
Omeprazole
Amoxicillin
The following induce acid secretion EXCEPT:
Histamine
Somatostatin
Gastrin
Acetylcholine
The receptors for the following molecules can be found in the parietal cell EXCEPT:
Histamine
Gastrin
Somatostatin
Acetylcholine
A patient continues to have suppressed gastric acid secretion for 48 hours despite stopping omeprazole. The most accurate explanation is:
Competitive inhibition of H₂ receptors
Long plasma half-life of omeprazole
Irreversible inhibition of active proton pumps
Increased parietal cell apoptosis
Which drug requires acidic activation within the parietal cell canaliculus to exert its effect?
Famotidine
Omeprazole
Sucralfate
Misoprostol
A patient on clopidogrel develops peptic ulcer disease. Which acid-suppressing drug is MOST appropriate to avoid reducing clopidogrel activation?
Famotidine
Omeprazole
Esomeprazole
Pantoprazole
Which drug provides ulcer protection primarily by enhancing mucosal prostaglandins?
Bismuth
Which mechanism BEST explains rebound acid hypersecretion after abrupt PPI withdrawal?
Increased histamine release
Upregulation of proton pumps
Hyperplasia of G cells
Increased acetylcholine sensitivity
Which ulcer drug interferes with absorption of tetracyclines and fluoroquinolones?
Omeprazole
Famotidine
Misoprostol
Sucralfate
Which patient would benefit MOST from misoprostol?
Zollinger–Ellison syndrome
Stress ulcer prophylaxis in ICU
NSAID-induced gastric ulcers
GERD refractory to PPIs
Which drug has direct anti–H. pylori activity?
Bismuth
Omeprazole
Vonoprazan
Misoprostol
A 26 year old female came in due to right upper quadrant pain, LBM and vomiting. Patient is a known case of MDD diagnosed by a psychiatrist on fluoxetine therapy. Whole abdominal ultrasound was done revealing acute cholecystitis. Symptomatic management was done and patient suddenly developed tachycardia, restlessness, agitation and confusion. What medication could have triggered the patient's symptoms?
Ondansetron
Metoclopramide
Meclizine
Hyoscine
A 67-year old female came in due to chronic constipation. Patient has been taking a certain medication for 15 days. Constipation was relieved until recently, the patient had no more bowel movement. Patient complained of bloatedness and abdominal pain. Further work-up of her colon showed no peristaltic activity. Which medication was the patient taking?
Castor oil
Bisacodyl
Docusate
Mineral oil
A 33 year old female came in for vomiting. The ER physician gave symptomatic management to the patient. After an hour of observation, patient was relieved from vomiting but had chest pain. Further workup revealed an ECG tracing of prolonged QT interval. What medication could have been given to the patient?
Scopolamine
Metoclopramide
Domperidone
Dolasetron
A 27 year old female was admitted due to many episodes of vomiting. Patient was managed as a case of acute gastritis, treated accordingly. Upon discharge, patient noted constant wet marks on her shirt, specifically at the upper chest area. Which medication could have caused this?
Metoclopramide
Scopolamine
Meclizine
Ondansetron
A 25 year old female with a BMI of 35.6 kg/m2 wanted to lose weight. She took a specific medication for 6 months which lead to chronic diarrhea. Patient sought consult with a gastroenterologist and endoscopy was done revealing brownish pigmentation of the colon. What medication did she take?
Bisacodyl
Senna
Castor oil
Magnesium hydroxide
