wayground logo

Free Printable Worksheets

NEW

Font size

S
M
L
XL
Worksheets

Drugs for Peptic Ulcer Disease

Total questions: 25

Worksheet time: 9mins

Name
Class
Date
1.

The following is true about antacids EXCEPT:

a)

They are given after meals

b)

It can cause metabolic alkalosis

c)

Acts on the channels at the parietal cells

d)

Neutralizes acid for up to 2 hours

2.

The following adverse effects are CORRECTLY matched EXCEPT:

a)

Sodium - water retention

b)

Magnesium - LBM

c)

Aluminum - diarrhea

d)

Calcium - milk alkali syndrome

3.

A patient develops confusion, gynecomastia, and decreased libido while on ulcer therapy. Which drug is MOST likely responsible?

a)

Ranitidine

b)

Famotidine

c)

Nizatidine

d)

Cimetidine

4.

Histamine release comes from which cells?

a)

G cells

b)

D cells

c)

ECL cells

d)

Parietal cells

5.

When should proton pump inhibitors be given?

a)

After breakfast

b)

Before breakfast

c)

Any time of the day

d)

Before bedtime

6.

What is the effect of pantoprazole in clopidogrel activation?

a)

It increase clopidogrel activation

b)

It decreases clopidogrel activation

c)

It initially decreases clopidogrel activation then increase

d)

It has minimal to no effect on clopidogrel activation

7.

Which among the drugs for peptic ulcer disease is most effective in inhibiting 24-hour acid secretion?

a)

Antacids

b)

H2-Receptor Antaognists

c)

Proton Pump Inhibitors

d)

Sucralfate

8.

This mucosal protective agent causes blackening of stool and darkening of tongue.

a)

Sucralfate

b)

Misoprostol

c)

Rebamipide

d)

Bismuth

9.

Why are PPIs administered 30–60 minutes before meals?

a)

Faster gastric emptying

b)

Prevent degradation by food

c)

Maximize inhibition of actively secreting pumps

d)

Reduce adverse effects

10.

The following is part of the triple therapy EXCEPT:

a)

Tetracycline

b)

Clarithromycin

c)

Omeprazole

d)

Amoxicillin

11.

The following induce acid secretion EXCEPT:

a)

Histamine

b)

Somatostatin

c)

Gastrin

d)

Acetylcholine

12.

The receptors for the following molecules can be found in the parietal cell EXCEPT:

a)

Histamine

b)

Gastrin

c)

Somatostatin

d)

Acetylcholine

13.

A patient continues to have suppressed gastric acid secretion for 48 hours despite stopping omeprazole. The most accurate explanation is:

a)

Competitive inhibition of H₂ receptors

b)

Long plasma half-life of omeprazole

c)

Irreversible inhibition of active proton pumps

d)

Increased parietal cell apoptosis

14.

Which drug requires acidic activation within the parietal cell canaliculus to exert its effect?

a)

Famotidine

b)

Omeprazole

c)

Sucralfate

d)

Misoprostol

15.

A patient on clopidogrel develops peptic ulcer disease. Which acid-suppressing drug is MOST appropriate to avoid reducing clopidogrel activation?

a)

Famotidine

b)

Omeprazole

c)

Esomeprazole

d)

Pantoprazole

16.

Which drug provides ulcer protection primarily by enhancing mucosal prostaglandins?

a)
Omeprazole
b)

Bismuth

c)
Sucralfate
d)
Misoprostol
17.

Which mechanism BEST explains rebound acid hypersecretion after abrupt PPI withdrawal?

a)

Increased histamine release

b)

Upregulation of proton pumps

c)

Hyperplasia of G cells

d)

Increased acetylcholine sensitivity

18.

Which ulcer drug interferes with absorption of tetracyclines and fluoroquinolones?

a)

Omeprazole

b)

Famotidine

c)

Misoprostol

d)

Sucralfate

19.

Which patient would benefit MOST from misoprostol?

a)

Zollinger–Ellison syndrome

b)

Stress ulcer prophylaxis in ICU

c)

NSAID-induced gastric ulcers

d)

GERD refractory to PPIs

20.

Which drug has direct anti–H. pylori activity?

a)

Bismuth

b)

Omeprazole

c)

Vonoprazan

d)

Misoprostol

21.

A 26 year old female came in due to right upper quadrant pain, LBM and vomiting. Patient is a known case of MDD diagnosed by a psychiatrist on fluoxetine therapy. Whole abdominal ultrasound was done revealing acute cholecystitis. Symptomatic management was done and patient suddenly developed tachycardia, restlessness, agitation and confusion. What medication could have triggered the patient's symptoms?

a)

Ondansetron

b)

Metoclopramide

c)

Meclizine

d)

Hyoscine

22.

A 67-year old female came in due to chronic constipation. Patient has been taking a certain medication for 15 days. Constipation was relieved until recently, the patient had no more bowel movement. Patient complained of bloatedness and abdominal pain. Further work-up of her colon showed no peristaltic activity. Which medication was the patient taking?

a)

Castor oil

b)

Bisacodyl

c)

Docusate

d)

Mineral oil

23.

A 33 year old female came in for vomiting. The ER physician gave symptomatic management to the patient. After an hour of observation, patient was relieved from vomiting but had chest pain. Further workup revealed an ECG tracing of prolonged QT interval. What medication could have been given to the patient?

a)

Scopolamine

b)

Metoclopramide

c)

Domperidone

d)

Dolasetron

24.

A 27 year old female was admitted due to many episodes of vomiting. Patient was managed as a case of acute gastritis, treated accordingly. Upon discharge, patient noted constant wet marks on her shirt, specifically at the upper chest area. Which medication could have caused this?

a)

Metoclopramide

b)

Scopolamine

c)

Meclizine

d)

Ondansetron

25.

A 25 year old female with a BMI of 35.6 kg/m2 wanted to lose weight. She took a specific medication for 6 months which lead to chronic diarrhea. Patient sought consult with a gastroenterologist and endoscopy was done revealing brownish pigmentation of the colon. What medication did she take?

a)

Bisacodyl

b)

Senna

c)

Castor oil

d)

Magnesium hydroxide