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WorksheetsRenal Pathology Quiz
Total questions: 19
Worksheet time: 10mins
In FSGS, what cellular component is primarily affected leading to proteinuria?
Endothelial cells
Podocytes
Mesangial cells
Tubular epithelial cells
What protein is primarily involved in the pathogenesis of Alport's syndrome?
Collagen Type I
Collagen Type II
Collagen Type III
Collagen Type IV
What is the inheritance pattern of Alport's syndrome in most cases?
Autosomal recessive
Autosomal dominant
X-linked
Mitochondrial
Which of the following is the most common cause of nephrotic syndrome in adults?
Minimal Change Disease
FSGS
Membranous nephropathy
Diabetic nephropathy
Which renal pathology is associated with subepithelial humps on electron microscopy?
Minimal Change Disease
FSGS
Post-infectious glomerulonephritis
Diabetic nephropathy
Which genetic mutation is most commonly associated with Nephrotic Syndrome due to Minimal Change Disease?
NPHS1
NPHS2
ACTN4
No genetic mutation
In which of the following conditions is the presence of kappa light chains in the urine a diagnostic feature?
Nephrotic syndrome
Multiple myeloma
Alport's syndrome
IgA nephropathy
What is a common complication of renal cysts in ADPKD patients?
Hypercalcemia
Renal cell carcinoma
Glomerulonephritis
Tubulointerstitial nephritis
Which of the following is a key feature of rapidly progressive glomerulonephritis (RPGN)?
Slow progression over years
Crescent formation in glomeruli
Lack of proteinuria
Normal kidney size on ultrasound
What is the gold standard for diagnosing FSGS?
Serum creatinine measurement
Renal biopsy
Urinalysis
Genetic testing
Which of the following is a hallmark feature of Thin Basement Membrane Disease (TBMD)?
Nephrotic syndrome
Persistent hematuria
Severe proteinuria
Rapidly progressive glomerulonephritis
What is the primary treatment strategy for managing hypertension in patients with ADPKD?
Beta-blockers
ACE inhibitors or ARBs
Calcium channel blockers
Diuretics
What is the primary genetic defect in Autosomal Recessive Polycystic Kidney Disease (ARPKD)?
PKHD1 gene
PKD1 gene
PKD2 gene
HNF1B gene
Which gene is commonly mutated in Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD)?
PKD1
PKD2
UMOD
NPHS1
What is a common presenting symptom of IgA nephropathy?
Hypokalemia
Hypercalcemia
Hematuria
Hypertension
In ADPKD, what is the role of the PKD2 gene?
Codes for polycystin-1
Codes for polycystin-2
Codes for fibrocystin
Codes for nephrin
What is the most common extra-renal manifestation in patients with ADPKD?
Pulmonary fibrosis
Pancreatic cysts
Hepatic cysts
Splenic cysts
What is a typical histological finding in patients with diabetic nephropathy?
Segmental glomerulosclerosis
Kimmelstiel-Wilson nodules
Subendothelial deposits
Subepithelial deposits
What is the main clinical consequence of ADTKD?
Nephrotic syndrome
Chronic kidney disease
Acute kidney injury
Rapidly progressive glomerulonephritis
