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Worksheetspathology chapter 1
Total questions: 50
Worksheet time: 26mins
Pathology, from the Greek words pathos and logos literally translates to?
study of suffering
study of diseases
This refers to chromosome tethers
telomeres
centromeres
This type of chromatin is recognizable as cytochemically dense and transcriptionally inactive
heterochromatin
euchromatin
What is the modification effect of histone acetyltransferases (HATs) on chromatin?
it tends to open the chromatin and increase transcription
It tends to condense the chromatin and decrease transcription
Linker DNAs are associated with what type of histone?
H1
H2A
H3
H4
pre-miRNA will be trimmed by what cytosolic enzyme?
RNA-induced silencing complexes (RISC)
Dicer
Base pairing between miRNA and its target RNA will lead to?
gene silencing
upregulation of gene expression
Knockdown technologies use what type of RNA to reproduce endogenous miRNA function?
siRNA
long noncoding RNA
Which of the following is/are roles of long noncoding RNA?
gene activation
gene suppression
chromatin modification
assembly of protein complexes
all given choices are correct
XIST which is involved in the physiologic X chromosome inactivation that occurs in females is an example of?
miRNA
lncRNA
siRNA
This is used in CRISPR gene editing to recognize the sequence of DNA to be edited?
guide DNA/ gDNA
guide RNA/ gRNA
What component of the CRISPR gene editing is used to cut target DNA inducing double-stranded DNA breaks at the site of gRNA binding.
dicer
RISC complex
Cas9 protein
This is used for steroid hormone and lipoprotein synthesis and modification of hydrophobic compounds into water-soluble molecules for export
rough endoplasmic reticulum
Golgi apparatus
smooth endoplasmic reticulum
free ribosomes
This is the site of senescent intracellular organelle breakdown or autophagy
proteasome
peroxisome
endosome
lysosome
This is where phagocytosed microbes are killed and catabolized
proteasome
lysosome
peroxisome
endosome
these are disposal complexes that degrade denatured or otherwise tagged cytosolic proteins
proteasome
lysosome
peroxisome
endosome
Plays a specialized role in the breakdown of very long chain fatty acids, generating hydrogen peroxide in the process
proteasome
lysosome
peroxisome
endosome
For intracellular transport or export or shuttles internalized material to the appropriate intracellular site
proteasome
lysosome
peroxisome
endosome
Nucleosomes are comprised of?
octamers of histone proteins encircled by DNA
histones wrapped centrally around chromosomes
These are repetitive nucleotide sequences that cap the termini of chromatids and permit repeated chromosomal replication without deterioration
centromere
telomeres
coding region of a gene
exons
introns
Which of the following is found in the inner leaflet of the plasma membrane?
phosphatidylcholine
sphingomyelin
phosphatidylserine
Which of the following is NOT a component of the cytoskeleton of a cell?
microfilaments
intermediate filaments
microtubule
all are components of the cytoskeleton
which of the following is NOT a function of mitochondria?
ATP generation
source of metabolic intermediates
apoptosis
synthesis of certain macromolecules such as heme
all are functions of the mitochondria
serves as an eat me signal during programmed cell death
phosphatidylinositol
phosphatidylcholine
phosphatidylserine
This form of solute transport across the plasma membrane is frequently driven by a concentration and or electrical gradient between the inside and outside of the cell
active transport
passive transport
This is the movement of endocytosed vesicles between the apical and basolateral compartments of the cell
exocytosis
transcytosis
Internalization of caveolae along with bound molecules and associated extracellular fluid is called?
potocytosis
exocytosis
This is the most abundant cytosolic protein in cells
actin
myosin
vimentin
lamins
this is an intermediate filament expressed mostly in mesenchymal cells
glial fibrillary protein
cytokeratin
vimentin
this is an intermediate filament usually expressed in muscle cells which forms the scaffold on which actin and myosin contract
desmin
neurofilaments
cytokeratins
this is an intermediate filament usually expressed in epithelial cells
lamin
glial fibrillary acidic protein
cytokeratin
vimentin
this cytoskeleton component mediate sister chromatid segregation during mitosis and can be adopted to form the core of motile cilia or flagella
actin microfilament
intermediate filament
microtubule
It seals adjacent epithelial cells together to create a continuous barrier that restricts the paracellular movement of ions and other molecules. It also represents the boundary that separates apical and basolateral domains of a cell and maintains cellular polarity
occluding junction
anchoring junction
communicating junction
These are noncoding DNA sequences
exon
intron
this permits the diffusion of chemical or electrical signals from one cell to another
anchoring junction
occluding junction
communicating junction
type of signaling that occurs when molecules secreted by a cell affect the same cell
paracrine
endocrine
autocrine
These transcription factors regulate cell division which are products of several growth promoting genes EXCEPT?
TP53
MYC
JUN
this is regarded as the major angiogenic factor
FGF
TGF-B
EGF
VEGF
This growth factor can be conceptualized as driving scar formation and putting a brake on the inflammation that accompanies wound healing; suppresses acute inflammation
VEGF
TGF-B
TGF-A
KGF
The ability of tissues to elastically recoil and return to a baseline structure after physical stress is conferred by
collagen
elastin
proteoglycans
this is the most abundant glycoprotein in the basement membrane and connects cells to underlying ECM
laminin
fibronectin
this is a major component of the interstitial ECM; it is involved in healing wounds, tissue and plasma fibronectin provide the scaffolding for subsequent ECM deposition
integrin
laminin
fibronectin
quiescent phase in cell cycle
G0
G1
G2
S
this cell cycle checkpoint primarily checks for unduplicated DNA
G1/S checkpoint
G1 restriction point
G2/M checkpoint
this type of nonfibrillar collagen contribute to structures of planar basement membrane
collagen I
collagen II
collagen III
collagen IV
This form of stem cell division refers to replication in which one daughter cell enters a differentiation pathway and gives rise to mature cells while the other remains undifferentiated
asymmetric division
symmetric division
this variety of stem cell is the most undifferentiated
embryonic stem cell
tissue stem cell
adult stem cell
this stem cell variety can be induced under appropriate conditions to form specialized cells of all three germ cell layers
embryonic stem cell
adult stem cell
this stem cell variety is produced when genes that confer stem cell properties are introduced into a patient's differentiated cells, giving rise to stem cells that can be induced to differentiate into various lineages
embryonic stem cell
adult stem cell
induced pluripotent stem cells
tissue stem cells
