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WorksheetsMICR Midterm
Total questions: 24
Worksheet time: 24mins
Which of the following are possible light chain isotypes?
λ
Κ
β
μ
γ
The hinge region lies between the...
2 constant domains of the heavy chains
Constant domains of the heavy chains & light chains
Variable domains of the heavy chains & light chains
Organize these lymphoid organs / tissues into the right category
Thymus
Bone marrow
Spleen
Lymph nodes
Mucosal surfaces have specialized immune structures in the gut mucosa called (a) that contain B & T cells. This is because their lining is thin so they have their own special lymph node system.
The humoral component of innate immunity is (a)
An (a) (aka antigenic determinants) is the region or antigen site that is recognized by the immune system (e.g., binds to lymphocyte receptors). These bind to specific Igs (immunoglobulins) or TCRs
Antibodies/BCRs are also known as ______, produced by B cells in a vast range of antigen specificities. However, each B cell produces ______ of a single-specificity
(a)
Which of the following is not a heavy chain isotype?
IgD (δ)
IgA (α)
IgB (β)
IgM (μ)
IgG (γ)
Which of the following is the first class of immunoglobulin co-expressed with IgM?
IgD (δ)
IgA (α)
IgE (ε)
IgG (γ)
Within an immunoglobulin exists _ heavy chains and _ light chains. Heavy chains are connected via _ disulfide bond(s). Each heavy chain is connected to a light chain via _ disulfide bond(s), totalling _ disulfide bonds across an immunoglobulin (antibody).
Type numbers as A, B, C, D, E
(a)
(a) : the total strength of the interaction between an antibody and antigen when both of the antigen binding sites bind – total binding strength of an antibody (b) : the strength of the interaction between a single antigen-binding site & an antigen. The antigen binding site, and thus the (c) region exists on the (d) of the immunoglobulin while the effector function OR the portion bound to surface of a BCR exists at the (e) .
IgM molecules found as (a) in plasma & have _ antigen-binding site(s)
The Ig_ and Ig_ molecules can form polymers by interacting with the _ chain
Type the 3 letters
(a)
After cleavage by the enzyme papain at the (a) region, 3 EQUALLY sized globular domains are formed; 2 being (b) & 1 being (c) .
The class or isotype of an antibody is determined by the structure of its ___ regions - different isotypes have different effector functions!
VH (variable region of the heavy chain)
VL (variable region of the light chain)
CH (constant region of the heavy chain)
CL (constant region of the light chain)
IgA molecules are found as (a) in mucous secretions but as (b) in plasma
Each antigen binding site has _ CDRs, totalling _ CDRS in a single antibody.
(a)
In each chain exists 3 hypervariable regions: HV1, HV2, HV3
The most variable part of the domain is...
Within the variable regions of both light chains and heavy chains exist hypervariable regions (HV) and (a) regions
True or false? T-cell recognizes carbohydrates on MHC.
True
False
In TCRS, the (a) chain is homologous to a BCR light chain (only has V & J segments) while the (b) chain is homologous to a BCR heavy chain (has V, D & J segments)
In cross-presentation, a dendritic cell takes up antigen from an exogenous source & brings it inside through a phagolysosome, breaking it up & presenting to MHC class _, an exception
Proteins in the cytosol are tagged for degradation via the ubiquitin - once _ ubiquitin molecules have attached, the protein can enter the proteasome system
(a)
Which of the following is NOT part of peptide loading complex (PLC)?
calnexin
TAP
calreticulin
tapasin
ERp57
