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WorksheetsSignal Transduction
Total questions: 22
Worksheet time: 15mins
A G-protien coupled receptor becomes activated when
GTP displaces GDP
a signaling molecule binds to the receptor
G protein releases its receptor
once the enzyme is activated
Receptor proteins can be found in the
nucleus
cytosol
cell membrane
all of the above
Which molecule will most likely diffuse across plasma membrane?
glucose
carbon dioxide
sodium ion
DNA
In eukaryotic cells, which is a second messenger that is produced as a response to an external signal such as a hormone?
cyclic AMP
glycogen
glucose
epinephrine
The source of the phosphate for a phosphorylation cascade is...
cAMP
protein kinase
ATP
GTP
An example of LOCAL cell communication is:
White blood cells bumping into each other sharing antigen info
Neurons communicating across a synapse
Hormones traveling through the blood stream to target tissues
(2) examples of second messengers are...
Ca 2+
protein kinase
cAMP
G-protein coupled receptor
Select all that are true about cAMP.
it is used to activate protein kinases in the signal transduction pathway
it is broken down by phosphodiesterase
it is a g-protein coupled receptor
it is formed by adenylyl cyclase
Why do different target cells respond differently to the same signaling molecule (multiple choice).
There are different response molecules in the cell
There are different signal transduction pathways
There are different receptors in plasma membrane
What are the two types of hormones and where are their receptors typically located?
lipid soluble, binds to receptors in plasma membrane
lipid soluble, bind to receptors in cytoplasm or nucleus
water soluble, binds to receptors in plasma membrane
water soluble, bind to receptors in cytoplasm or nucleus
If phosphorylation (of ATP or GTP) did not occur, what would happen?
The ligand would bind, and the signaling pathway would proceed through transduction to cellular response.
The ligand would bind, but the signaling pathway would not proceed through the transduction step.
The ligand would bind and the signaling pathway would proceed through the transduction step, but would not produce a cellular response.
Choose all correct answer choices regarding the calcium ion.
Acts as a second messenger in the signal transduction pathway
Is found in low concentrations outside the cell
Is released from the mitochondria and endoplasmic reticulum when a cell signaling molecule binds to a cell-surface receptor
Is found in low concentrations in the cytoplasm
