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DNA Gene Expression and Mutations

Total questions: 21

Worksheet time: 12mins

Name
Class
Date
1.
What is the relationship between a protein, the cell, and DNA?
a)
DNA is produced by protein which is produced in the cell
b)
Protein is composed of DNA which is produced in the cell
c)
DNA controls the production of protein in the cell
d)
A cell is composed of DNA and protein
2.
A mutation that does NOT alter the protein production is called a 
a)
deletion mutation
b)
inversion mutation
c)
silent mutation
d)
transverse mutation
3.
DNA molecule segment is : TTACGCAAG
The mutated DNA segment is TTATCGCAAG. This is an example of ___ mutation.
a)
Deletion
b)
Substitution
c)
Insertion
d)
Inversion
4.
In eukaryotes, proteins that help the RNA polymerase bind to the promoter for transcription
a)
transcription factors
b)
topoisomerase
c)
regulatory genes
d)
activators
5.
How can a person's muscle cells have the same exact DNA sequences as their nerve cells even though the look and perform completely different?
a)
The two different cells become mutated
b)
The proteins expressed in each cell are different
c)
They actually have different DNA in the two types of cells.
d)
The genome of the different cells changes
6.
The process by which a cell becomes specialized for a specific structure or function.
a)
cell multiplication
b)
cell division
c)
mitosis
d)
cell differentiation
7.
A chemical modification of DNA that does not affect the nucleotide sequence of a gene but makes that gene less likely to be expressed.
a)
methylation
b)
acetylation
c)
alternative splicing
d)
snRPs
8.
During DNA methylation
a)
mRNA molecules are prohibited from being translated
b)
a methyl cap is added to the 5' end to prevent DNA degredation
c)
transcription factor proteins recruit RNA polymerase initiating transcription
d)
chromatin becomes more tightly packed
9.

The diefinition of a mutation is...

a)

a change in a DNA sequence

b)

A change in mRNA

c)

A change in amino acid sequence

d)

Wolverine

10.

A segment of DNA has base sequence GAC GAC CGC AAA ACA AGC. Due to deletion, the first base G is deleted. The likely effect of this on the coding of DNA segment is that

a)

the first amino acid will be different and all other will be like the original polypeptide.

b)

there will be no change in the polypeptide chain.

c)

the whole sequence of amino acids will be changed.

d)

the polypeptide chain will be two amino acids shorter

11.

Mutations can be

a)

Harmful

b)

Neutral

c)

Benificial

d)

All of the above

12.

Which type of mutations can be inherited

a)

Mutations in somatic cells

b)

Spontanious mutations in muscle cells

c)

Mutations in germline cells

d)

Induced mutations in liver cells.

13.

The least severe form of mutation is likely to be:

a)

a substitution of a nucleotide

b)

a single DNA nucleotide insertion in the middle of a sequence

c)

a loss or gain of part of a chromosome

d)

the loss or gain of a chromosome

14.

Match the following about mutations

a)

mutation

1.

a change in the DNA sequence

b)

substitution

2.

replacing a nucleotide with a different nucleotide

c)

deletion

3.

removing a nucleotide

d)

insertion

4.

adding a nucleotide

15.

Match the following about mutations

a)

gene mutation

1.

a change in a nucleotide or a segment of DNA

b)

chromosomal mutation

2.

a change in structure of a chromosome

c)

point mutation

3.

a change in only a single nucleotide

d)

frameshift mutation

4.

a change that affects all amino acids after the mutation; insertions or deletions

16.

All cells carry the entire genome of an organism apart from:

a)

hair follicles and gametes.

b)

skin cells and gametes.

c)

gametes and red blood cells.

d)

gametes.

17.

Negative control of gene expression is mediated by __ and results in a(n) __ in the frequency of transcription.

a)

activators, increase

b)

activators, decrease

c)

repressors, increase

d)

repressors, decrease

18.

Which of the genes below would you want to have demethylated in your body? Select all that apply.

a)

Cancer causing genes

b)

Genes associated with anxiety.

c)

tumor suppressor genes

d)

genes related to immune system function

19.
Protein molecules around which DNA is tightly coiled in chromatin
a)
Histones
b)
Whey
c)
Casein
d)
Hemoglobin
20.

Which of these can cause a gene to be expressed more - that is, can cause more protein to be made from it?

a)

removal of methyl groups from the DNA

b)

loosening of how tight the DNA is coiled around histones

c)

both of these are correct

21.

How can epigenetic changes be inherited?

a)

Through changes in the DNA sequence passed from parent to offspring

b)

Through the inheritance of acquired characteristics

c)

Through the replication of epigenetic markers during cell division

d)

Epigenetic changes cannot be inherited