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Medical Biochemistry Past Test Paper

Total questions: 17

Worksheet time: 26mins

Name
Class
Date
1.

The peptide bond in proteins is

a)

Planar, but rotates to three preferred dihedral angles

b)

Non planar, but rotates to three preferred dihedral angles

c)

Non-planar, and fixed in a trans conformation

d)

Planar, and usually found in a trans conformation

2.

Control of urea cycle involves the enzyme

a)

Carbamoyl phosphate synthetase

b)

Ornithine transcarbamoylase

c)

Arginino-succinase

d)

Arginase

3.

At neutral pH a mixture of amino acids in solution would be predominantly

a)

Dipolar

b)

Nonpolar molecules

c)

Positive and monovalent

d)

Hydrophobic

4.

Which of the following forces is the most favourable for protein folding?

a)

Conformational entropy

b)

Hydrophobic interactions

c)

Van Der Waals interactions

d)

Hydrogen bonds

5.

Calculate the pH of a mixture of 0.3M acetic acid and 0.2M sodium acetate. The pKa of acetic acid is 4.76

a)

5.1

b)

4.1

c)

6.1

d)

4.9

6.

An allosteric activator

a)

Increases the binding affinity

b)

Decreases the binding affinity

c)

Increases the Km number

d)

Binds the enzyme at the active site

7.

A compound serving a link between citric acid cycle and urea cycle is

a)

Malate

b)

Succinate

c)

Fumarate

d)

Citrate

8.

Nonessential amino acids

a)

Are not components of tissue proteins

b)

May be synthesised in the body from essential amino acids

c)

Have no role in the metabolism

d)

May be synthesised in the body even in diseased states

9.

Fatty acids can be transported into and out of the cell plasma membrane by

a)

Active transport

b)

Diffusion

c)

Facilitated transport

d)

Osmosis

10.

The two amino acids having R groups with a negative net charge at pH 7.4 are

a)

Aspartate and glutamate

b)

Arginine and histidine

c)

Cysteine and methionine

d)

Proline and Valine

11.

Describe transport of molecules across cell plasma membrane with examples where possible.

4 lines
12.

Briefly explain the international classification of enzymes

4 lines
13.

Determine the pH of a solution prepared by dissolving 0.45mole of Chloride in 1.0L of 0.35M aqueous ammonia. Kb for ammonia equals 1.77 * 10-5

4 lines
14.

Write briefly about the structure and function of starch and glycogen

4 lines
15.

Write about structure of cell plasma membrane

4 lines
16.

Classify proteins based on composition giving examples for each.

4 lines
17.

Describe the Urea cycle, clearly stating the enzymes involved at each step

4 lines