NEW
Font size
WorksheetsHeme Synthesis and Disorders Quiz
Total questions: 20
Worksheet time: 10mins
Which amino acid is the precursor for heme synthesis?
Glycine
Alanine
Glutamate
Lysine
Which enzyme catalyzes the first step of heme synthesis?
ALA synthase
ALA dehydratase
Ferrochelatase
Porphobilinogen deaminase
Which coenzyme is required for ALA synthase?
PLP
FAD
THF
CoA
Porphobilinogen is formed from which intermediate?
ALA
Uroporphyrinogen I
Protoporphyrin IX
Hematin
Which is the rate-limiting enzyme of heme synthesis?
ALA synthase
Ferrochelatase
Uroporphyrinogen decarboxylase
Hem oxygenase
Which metal ion is inserted into protoporphyrin to form heme?
Iron
Zinc
Copper
Magnesium
Which enzyme catalyzes the insertion of iron into protoporphyrin IX?
Ferrochelatase
ALA synthase
Uroporphyrinogen synthase
Porphobilinogen deaminase
Acute intermittent porphyria is due to deficiency of which enzyme?
Porphobilinogen deaminase
Ferrochelatase
ALA synthase
Uroporphyrinogen decarboxylase
Which porphyria leads to photosensitivity?
Porphyria cutanea tarda
Acute intermittent porphyria
ALA dehydratase deficiency
Lead poisoning
In lead poisoning, which enzymes are inhibited?
ALA dehydratase and Ferrochelatase
ALA synthase and Hem oxygenase
Porphobilinogen deaminase and Uroporphyrinogen decarboxylase
Ferrochelatase and Hem oxygenase
Which form of bilirubin is water soluble?
Conjugated bilirubin
Unconjugated bilirubin
Delta bilirubin
Free bilirubin
Which enzyme conjugates bilirubin in the liver?
UDP-glucuronyl transferase
Hem oxygenase
Ferrochelatase
ALA synthase
Unconjugated hyperbilirubinemia is seen in?
Crigler-Najjar syndrome
Dubin-Johnson syndrome
Obstructive jaundice
All of the above
Which type of bilirubin increases in obstructive jaundice?
Conjugated bilirubin
Unconjugated bilirubin
Delta bilirubin
Total bilirubin
Sickle cell anemia is due to substitution of which amino acid?
Valine replaces Glutamic acid
Lysine replaces Glutamic acid
Glycine replaces Valine
Alanine replaces Lysine
Thalassemia is a disorder of?
Globin chain synthesis
Heme synthesis
Iron metabolism
Bilirubin conjugation
HbF consists of which chains?
α2γ2
α2β2
α2δ2
β2γ2
Which hemoglobin has highest affinity for oxygen?
HbF
HbA
HbA2
Methemoglobin
Which is the normal adult hemoglobin?
HbA
HbF
HbA2
HbS
Which test is used for detection of Sickle Cell Trait?
Sickling test
Van den Bergh test
Schilling test
Sudan test
